INT93058

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Context Info
Confidence 0.28
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.11
Pain Relevance 2.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Ednra) plasma membrane (Ednra) signal transducer activity (Ednra)
Anatomy Link Frequency
hypothalamus 2
sympathetic 2
Ednra (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 10 99.98 Very High Very High Very High
electroacupuncture 8 99.96 Very High Very High Very High
analgesia 3 99.84 Very High Very High Very High
qutenza 81 93.08 High High
antagonist 39 88.36 High High
Inflammation 19 86.48 High High
Analgesic 5 85.20 High High
bradykinin 20 81.68 Quite High
Nerve growth factor 1 80.04 Quite High
Pain threshold 1 78.60 Quite High
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 302 100.00 Very High Very High Very High
Congenital Anomalies 12 100.00 Very High Very High Very High
Cv Unclassified Under Development 1 99.98 Very High Very High Very High
Stress 17 99.12 Very High Very High Very High
Cardiovascular Disease 12 97.44 Very High Very High Very High
Cv General 4 Under Development 17 96.28 Very High Very High Very High
Body Weight 1 95.88 Very High Very High Very High
Middle Cerebral Artery Infarction 15 91.76 High High
Aging 6 87.20 High High
INFLAMMATION 25 86.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The tone of the coronary arteries is critically dependent on an activation of ET receptors and an increased ET-1 associates with a proportional decrease in NO accompanying coronary endothelial dysfunction.46 Vascular abnormalities resulting from over-expression of endothelin receptor, leptin, and NOX and stress contribute to an increased risk of CVD (cardiovascular disease).
Positive_regulation (dependent) of Gene_expression (over) of endothelin receptor associated with stress, cardiovascular disease and congenital anomalies
1) Confidence 0.28 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 1.12 Pain Relevance 0.04
Our group has previously shown that in addition to an ischemia-induced endothelin receptor upregulation, there is an alteration in the vascular angiotensin II receptor response after experimental cerebral ischemia [27].
Positive_regulation (induced) of Gene_expression (upregulation) of endothelin receptor associated with cv general 4 under development and ischemia
2) Confidence 0.23 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1770924 Disease Relevance 0.73 Pain Relevance 0.35
Damaged sympathetic neurones markedly increase ET mRNA expression.
Positive_regulation (increase) of Gene_expression (expression) of ET mRNA in sympathetic
3) Confidence 0.14 Published 2000 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 11154842 Disease Relevance 0 Pain Relevance 0.10
Oral sildenafil, a PDE5 inhibitor, prevented (in a study in which sildenafil was given 1 day after MCT) and reversed (in a study in which sildenafil was given 3 weeks after MCT) the development of PAH in MCT-treated rats, associated with a reduction in the ETA-receptor density in SMCs of pulmonary small arteries (diameter < 100??
Positive_regulation (after) of Gene_expression (density) of ETA-receptor associated with pulmonary hypertension
4) Confidence 0.11 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 1.03 Pain Relevance 0.30
Oral sildenafil, a PDE5 inhibitor, prevented (in a study in which sildenafil was given 1 day after MCT) and reversed (in a study in which sildenafil was given 3 weeks after MCT) the development of PAH in MCT-treated rats, associated with a reduction in the ETA-receptor density in SMCs of pulmonary small arteries (diameter < 100??
Positive_regulation (after) of Gene_expression (density) of ETA-receptor associated with pulmonary hypertension
5) Confidence 0.11 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 1.06 Pain Relevance 0.34
Effects of ET-1 on HEK293 cells transiently transfected with TRPV1 and the ETA or ETB receptor
Positive_regulation (with) of Gene_expression (transfected) of ETA
6) Confidence 0.06 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0 Pain Relevance 0.52
Effects of ET-1 on HEK293 cells transiently transfected with TRPV1 and the ETA or ETB receptor
Positive_regulation (transfected) of Gene_expression (transfected) of ETA
7) Confidence 0.06 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0 Pain Relevance 0.52
Taken together, these results suggest that adenoviral expression of the AChET gene in the hypothalamus potentiates EA analgesia in rats without apparent side-effects.
Positive_regulation (potentiates) of Gene_expression (expression) of AChET in hypothalamus associated with electroacupuncture and analgesia
8) Confidence 0.04 Published 2009 Journal Genes Brain Behav. Section Abstract Doc Link 19077179 Disease Relevance 0.17 Pain Relevance 0.71

General Comments

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