INT93060

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Context Info
Confidence 0.50
First Reported 2000
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.23
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (gr)
gr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 11 99.20 Very High Very High Very High
cINOD 3 96.52 Very High Very High Very High
Multiple sclerosis 17 80.56 Quite High
rheumatoid arthritis 4 79.44 Quite High
cytokine 7 65.04 Quite High
corticosteroid 1 14.48 Low Low
dexamethasone 22 5.12 Low Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 17 99.20 Very High Very High Very High
Stress 1 88.32 High High
Diabetes Mellitus 1 85.80 High High
Muscular Atrophy 1 85.32 High High
Osteoporosis 1 84.68 Quite High
Multiple Sclerosis 50 80.56 Quite High
Rheumatoid Arthritis 4 79.44 Quite High
Disease 11 78.12 Quite High
Repression 3 71.16 Quite High
Apoptosis 37 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the immunosuppressive and anti-inflammatory activity of glucocorticoids is largely independent of GR DNA-binding, suggesting that GRdim mice might be useful in the future for the search of steroidal anti-inflammatory drugs with reduced side-effects.
Neg (independent) Positive_regulation (independent) of GR Binding (binding) of associated with inflammation and cinod
1) Confidence 0.50 Published 2000 Journal Z Rheumatol Section Abstract Doc Link 11155788 Disease Relevance 0.42 Pain Relevance 0.15
One strategy is based on the notion that adverse effects are often mediated by transactivation after GR binding to promoter and enhancer elements present in target genes.
Positive_regulation (transactivation) of GR Binding (binding) of
2) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.81 Pain Relevance 0.31

General Comments

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