INT93061

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Context Info
Confidence 0.48
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 31
Total Number 32
Disease Relevance 10.93
Pain Relevance 6.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (gr)
Anatomy Link Frequency
nucleus 6
spinal 1
AtT20 1
gr (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 5 100.00 Very High Very High Very High
corticosteroid 182 99.98 Very High Very High Very High
cINOD 29 99.44 Very High Very High Very High
Inflammation 262 98.90 Very High Very High Very High
Morphine 13 98.36 Very High Very High Very High
dexamethasone 755 98.00 Very High Very High Very High
bDMF 38 97.48 Very High Very High Very High
cytokine 127 97.44 Very High Very High Very High
depression 13 97.04 Very High Very High Very High
tolerance 10 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 200 99.48 Very High Very High Very High
Asthma 44 99.44 Very High Very High Very High
INFLAMMATION 379 99.20 Very High Very High Very High
Disease 163 98.84 Very High Very High Very High
Shock 9 98.84 Very High Very High Very High
Apoptosis 228 98.20 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 98.20 Very High Very High Very High
Depression 17 97.04 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 324 95.76 Very High Very High Very High
Repression 24 95.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To decipher the molecular mode of action of GR, mice were generated by gene targeting, carrying a point mutation in one of the dimerization domains, thus abrogating DNA binding by GR.
GR Binding (binding) of
1) Confidence 0.48 Published 2000 Journal Z Rheumatol Section Abstract Doc Link 11155788 Disease Relevance 0.33 Pain Relevance 0.09
Furthermore, the immunosuppressive and anti-inflammatory activity of glucocorticoids is largely independent of GR DNA-binding, suggesting that GRdim mice might be useful in the future for the search of steroidal anti-inflammatory drugs with reduced side-effects.
GR Binding (binding) of associated with inflammation and cinod
2) Confidence 0.48 Published 2000 Journal Z Rheumatol Section Abstract Doc Link 11155788 Disease Relevance 0.42 Pain Relevance 0.15
Thus, the present study supports the notion that the interaction of antidepressants with GR may play a role in attenuating pathological hyperactivity of HPA axis in depression.
GR Binding (interaction) of associated with antidepressant, depression and attention deficit hyperactivity disorder
3) Confidence 0.41 Published 2008 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18441395 Disease Relevance 0.25 Pain Relevance 0.31
These results are compatible with the concept that CpdA represents a dissociating GR ligand.
GR Binding (ligand) of
4) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.32 Pain Relevance 0.28
Dissociating glucocorticoid receptor (GR) ligands hold great promise for treating inflammatory disorders since it is assumed that they exert beneficial activities mediated by transrepression but avoid adverse effects of GR action requiring transactivation.
GR Binding (Dissociating) of associated with inflammation
5) Confidence 0.23 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2781169 Disease Relevance 0.51 Pain Relevance 0.14
One strategy is based on the notion that adverse effects are often mediated by transactivation after GR binding to promoter and enhancer elements present in target genes.
GR Binding (binding) of
6) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.80 Pain Relevance 0.30
Support for this concept came from of the analysis of GRdim mice that are defective in GR dimerization and DNA-binding [8], [9].
GR Binding (binding) of
7) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.64 Pain Relevance 0.27
In addition to the GRE-dependent roles, the GR is capable of interacting with other co-activators and repressors to influence transcription indirectly [102,103].
GR Binding (interacting) of
8) Confidence 0.19 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0.09 Pain Relevance 0.14
Variations on the genomic functions of GC include transcriptional regulation at the level of protein-protein interactions between the GR and other transcription factors, co-activators or co-repressors.
GR Binding (interactions) of
9) Confidence 0.19 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0.10 Pain Relevance 0.15
Binding to composite GREs involves homodimerization of the GR to bind a non-palindromic consensus sequence comprised of two GR binding sites and is generally associated with transcriptional activation.
GR Binding (homodimerization) of
10) Confidence 0.15 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0.18 Pain Relevance 0.11
In the nucleus, the GR binds a GRE sequence.
GR Binding (binds) of in nucleus
11) Confidence 0.15 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0.14 Pain Relevance 0.18
Specific non-genomic GC regulation occurs through the classical GR and its cytoplasmic heteroprotein complex or non-classical GRs such as membrane GR [106-109].
GR Binding (complex) of
12) Confidence 0.14 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0 Pain Relevance 0.11
Possible variations of total glutathione levels and GR and ?
GR Binding (variations) of
13) Confidence 0.14 Published 2007 Journal Malar J Section Body Doc Link PMC1864988 Disease Relevance 0.20 Pain Relevance 0.08
A correlation analysis and a simple linear regression were made to assess the association between GR and ?
GR Binding (association) of
14) Confidence 0.13 Published 2007 Journal Malar J Section Body Doc Link PMC1864988 Disease Relevance 0.07 Pain Relevance 0
Classical genomic GC action is thought to be mediated by a cytoplasmic GR that modifies transcription upon binding its cognate ligand and translocating to the nucleus.
GR Binding (binding) of in nucleus
15) Confidence 0.13 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0.14 Pain Relevance 0.22
One candidate molecule is the anti-apoptotic co-chaperone BAG-1 which together with the chaperone HSP-70 is involved in regulation of GR binding activity [21].
GR Binding (binding) of associated with apoptosis
16) Confidence 0.13 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 1.24 Pain Relevance 0.15
GR glucocorticoid receptors
GR Binding (receptors) of
17) Confidence 0.11 Published 2005 Journal Ann Gen Psychiatry Section Body Doc Link PMC1090442 Disease Relevance 0.40 Pain Relevance 0.23
In the majority of these genes, GR can attenuate the promoter activity by a squelching or tethering effect to other factors without binding directly to GRE.
GR Binding (binding) of
18) Confidence 0.09 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.06 Pain Relevance 0.03
Three serial GRE half-sites are recognized in the above short sequences, all of which are involved in the negative regulation of the CRH gene transcription by the direct binding of GR. 8-bromo cAMP-induced CRH gene promoter activity is significantly reduced by glucocorticoid in AtT20 cells; however, this suppressive effect is abolished in the deleted or mutated construct lacking these nGRE site(s).
GR Binding (binding) of in AtT20
19) Confidence 0.07 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.10
There is an interesting report about the interaction of GR and a coactivator in the CRH gene regulation by glucocorticoid (van der Laan et al. in press).
GR Binding (interaction) of
20) Confidence 0.07 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.16

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