INT93062

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Context Info
Confidence 0.43
First Reported 2000
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.18
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (gr)
gr (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 7 97.44 Very High Very High Very High
Paracetamol 1 85.32 High High
Inflammation 11 68.00 Quite High
Multiple sclerosis 17 64.84 Quite High
rheumatoid arthritis 4 63.72 Quite High
cINOD 3 59.24 Quite High
corticosteroid 1 46.88 Quite Low
dexamethasone 22 37.52 Quite Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malaria 11 95.88 Very High Very High Very High
Repression 3 90.36 High High
Stress 3 87.68 High High
Diabetes Mellitus 1 70.08 Quite High
Muscular Atrophy 1 69.60 Quite High
Osteoporosis 1 68.96 Quite High
INFLAMMATION 17 68.00 Quite High
Multiple Sclerosis 50 64.84 Quite High
Rheumatoid Arthritis 4 63.72 Quite High
Disease 12 62.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To decipher the molecular mode of action of GR, mice were generated by gene targeting, carrying a point mutation in one of the dimerization domains, thus abrogating DNA binding by GR.
Negative_regulation (abrogating) of GR Binding (binding) of
1) Confidence 0.43 Published 2000 Journal Z Rheumatol Section Abstract Doc Link 11155788 Disease Relevance 0.33 Pain Relevance 0.09
Support for this concept came from of the analysis of GRdim mice that are defective in GR dimerization and DNA-binding [8], [9].
Negative_regulation (defective) of GR Binding (binding) of
2) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.65 Pain Relevance 0.27
Possible variations of total glutathione levels and GR and ?
Spec (Possible) Negative_regulation (Possible) of GR Binding (variations) of
3) Confidence 0.16 Published 2007 Journal Malar J Section Body Doc Link PMC1864988 Disease Relevance 0.20 Pain Relevance 0.09

General Comments

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