INT93063

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Context Info
Confidence 0.14
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.79
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) pigmentation (gr) nucleus (Jun)
DNA binding (Jun) transcription factor binding (Jun)
Anatomy Link Frequency
skin 1
gr (Mus musculus)
Jun (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 14 96.32 Very High Very High Very High
metalloproteinase 1 92.92 High High
dexamethasone 31 91.44 High High
amygdala 8 83.12 Quite High
cINOD 3 82.88 Quite High
cytokine 20 76.56 Quite High
Inflammatory mediators 4 62.44 Quite High
Multiple sclerosis 17 57.00 Quite High
Kinase C 12 5.00 Very Low Very Low Very Low
Neuropeptide 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 29 97.56 Very High Very High Very High
INFLAMMATION 21 96.32 Very High Very High Very High
Death 13 84.08 Quite High
Apoptosis 37 79.56 Quite High
Repression 3 77.96 Quite High
Multiple Sclerosis 50 57.00 Quite High
Disease 11 21.32 Low Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Central Nervous System Disease 6 5.00 Very Low Very Low Very Low
Hyponatremia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specifically, stress erythropoiesis was found to require the DNA binding-dependent function of GR whereas the antitumor-promoting activity of GR in skin is mediated by interaction with the transcription factor AP-1.
GR Binding (interaction) of AP-1 in skin associated with stress
1) Confidence 0.14 Published 2000 Journal Z Rheumatol Section Abstract Doc Link 11155788 Disease Relevance 0.35 Pain Relevance 0.13
GR interacts with numerous transcription factors and intracellular signaling cascades, such as AP1, CREB, NFkB, NGFI-B/Nurr77, STAT family members, and MAPKs, achieving the multipotential effect of glucocorticoid (Liberman et al. 2007).
GR Binding (interacts) of AP1
2) Confidence 0.06 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.13
MMP-13 expression is controlled by the transcription factor AP-1 and becomes repressed by GCs through direct protein-protein-interaction of the GR with AP-1 [28].
GR Binding (interaction) of AP-1
3) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.44 Pain Relevance 0.31

General Comments

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