INT931

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Context Info
Confidence 0.18
First Reported 1979
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 0.08
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Spic) DNA binding (Spic)
Anatomy Link Frequency
plasma 1
dorsum 1
Spic (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 21 100.00 Very High Very High Very High
Dopamine 5 99.58 Very High Very High Very High
Opioid 6 98.08 Very High Very High Very High
narcan 6 88.56 High High
fluoxetine 2 85.52 High High
Serotonin 3 84.40 Quite High
cytokine 12 77.28 Quite High
anesthesia 3 67.12 Quite High
Disease Link Frequency Relevance Heat
Immunization 2 78.80 Quite High
Helminth Infection 2 35.12 Quite Low
Alopecia 2 21.76 Low Low
Decapitation 2 7.36 Low Low
Poisoning 4 5.00 Very Low Very Low Very Low
Paralysis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PRF also is found in mental gland secretions in Plethodon species (such as P. cinereus) that deliver pheromone by swabbing mental gland secretions on areas of the female's dorsum that have been abraded by the male's premaxillary teeth [39], thus "injecting" the molecule systemically.
Localization (secretions) of PRF in dorsum
1) Confidence 0.18 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1550415 Disease Relevance 0 Pain Relevance 0.07
Experiment 1: PRF application to females
Localization (application) of PRF
2) Confidence 0.16 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1550415 Disease Relevance 0 Pain Relevance 0
This prolactin-releasing factor (PRF)-like activity was not altered in plasma from rats treated with bromocryptine or chlorpromazine despite significant suppression and stimulation of plasma PRL levels, respectively.
Localization (releasing) of PRF in plasma
3) Confidence 0.09 Published 1979 Journal Neuroendocrinology Section Abstract Doc Link 114870 Disease Relevance 0 Pain Relevance 0.28
In the present study, we have completely blocked the dopaminergic receptors in normal male rats by pretreatment with a large dose of pimozide (3 mg/kg) to demonstrate if putative PRF has a role in morphine-induced prolactin release.
Localization (release) of PRF associated with morphine
4) Confidence 0.03 Published 1988 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2907416 Disease Relevance 0 Pain Relevance 0.84
Morphine and related opioids may indirectly stimulate prolactin release by inhibiting PIF release and (or) by stimulating putative PRF release.
Localization (release) of PRF associated with opioid and morphine
5) Confidence 0.03 Published 1988 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2907416 Disease Relevance 0 Pain Relevance 0.70
Prolactin release is controlled by prolactin-release inhibiting factor (PIF), possibly dopamine, and an unidentified putative hypothalamic prolactin-releasing factor (PRF).
Localization (releasing) of PRF associated with dopamine
6) Confidence 0.03 Published 1988 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2907416 Disease Relevance 0 Pain Relevance 0.55
The proestrous surge of PRL could result from a decrease in dopamine, an increase in PRL-releasing factor (PRF) or both.
Localization (releasing) of PRF associated with dopamine
7) Confidence 0.03 Published 1989 Journal Endocrinology Section Abstract Doc Link 2492217 Disease Relevance 0.08 Pain Relevance 0.12

General Comments

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