INT9310

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Context Info
Confidence 0.49
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 20
Total Number 20
Disease Relevance 6.55
Pain Relevance 4.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ssr1)
Anatomy Link Frequency
limb 3
nucleus 1
autonomic 1
neuronal 1
blood 1
Ssr1 (Mus musculus)
Pain Link Frequency Relevance Heat
bradykinin 7 100.00 Very High Very High Very High
antagonist 3 100.00 Very High Very High Very High
qutenza 6 99.60 Very High Very High Very High
phenol injection 6 98.92 Very High Very High Very High
lidocaine 3 98.82 Very High Very High Very High
carpal tunnel syndrome 14 97.56 Very High Very High Very High
c fibre 4 97.08 Very High Very High Very High
Action potential 3 95.96 Very High Very High Very High
Pain 11 94.76 High High
Clonidine 2 93.80 High High
Disease Link Frequency Relevance Heat
Neuropathy 36 99.90 Very High Very High Very High
Familial Amyloidotic Polyneuropathy 4 99.88 Very High Very High Very High
Cv Unclassified Under Development 20 99.84 Very High Very High Very High
Acid Base Imbalance 2 99.52 Very High Very High Very High
Sleep Disorders 7 99.02 Very High Very High Very High
Congenital Anomalies 1 97.98 Very High Very High Very High
Carpal Tunnel Syndrome 14 97.56 Very High Very High Very High
Syndrome 12 97.20 Very High Very High Very High
Pain 10 94.76 High High
Hereditary Sensory And Autonomic Neuropathies 2 94.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SSR was abolished in the treated limb after phenol injection in only 64% of the cases.
Negative_regulation (abolished) of SSR in limb associated with phenol injection
1) Confidence 0.49 Published 1996 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 8884696 Disease Relevance 0.40 Pain Relevance 0.23
The acoustic SSR was unaffected by ischaemia, and thus the efferent limb of the SSR was not blocked, indicating that ischaemia does not affect the post-ganglionic efferent C fibres.
Negative_regulation (blocked) of SSR in limb associated with c fibre and cv unclassified under development
2) Confidence 0.42 Published 1992 Journal Pain Section Abstract Doc Link 1408313 Disease Relevance 0.61 Pain Relevance 0.42
The acoustic SSR was unaffected by ischaemia, and thus the efferent limb of the SSR was not blocked, indicating that ischaemia does not affect the post-ganglionic efferent C fibres.
Neg (unaffected) Negative_regulation (unaffected) of SSR in limb associated with c fibre and cv unclassified under development
3) Confidence 0.37 Published 1992 Journal Pain Section Abstract Doc Link 1408313 Disease Relevance 0.60 Pain Relevance 0.40
In FAP, the SSR were lost at an early stage.
Negative_regulation (lost) of SSR associated with familial amyloidotic polyneuropathy
4) Confidence 0.37 Published 1999 Journal Muscle Nerve Section Abstract Doc Link 10454728 Disease Relevance 0.79 Pain Relevance 0.14
SSR recorded with a surface electrode was much larger than that was taken with a needle electrode inserted deep under the skin, and was markedly reduced by an intravenous administration of atropine sulfate 0.5mg for about 10 min.
Negative_regulation (reduced) of SSR in skin
5) Confidence 0.36 Published 1989 Journal Masui Section Abstract Doc Link 2709606 Disease Relevance 0.25 Pain Relevance 0.26
The post-injection abolition of SSR was correlated with the clinical improvement rate: 11% when SSR was still present, but 75% when SSR was abolished.
Negative_regulation (abolished) of SSR
6) Confidence 0.36 Published 1996 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 8884696 Disease Relevance 0.38 Pain Relevance 0.21
In no other patient was sedation or respiratory alkalosis found to account for a lack of SSR at the time of admission.
Negative_regulation (lack) of SSR in respiratory associated with sleep disorders and acid base imbalance
7) Confidence 0.28 Published 2003 Journal BMC Pulm Med Section Body Doc Link PMC305355 Disease Relevance 0.26 Pain Relevance 0
In the patient groups, absence of SSR was never observed either in mild/moderate or in the severe CTS hands.
Negative_regulation (absence) of SSR associated with carpal tunnel syndrome
8) Confidence 0.23 Published 2006 Journal Eur. J. Neurol. Section Abstract Doc Link 16722968 Disease Relevance 0.70 Pain Relevance 0.70
This long time series has enabled us to report on the reciprocal importance of KNP and SSR to the elephant and its attendant herd and that since the fence between the two reserves was dropped, the elephants consistently rely upon KNP for summer grazing and SSR for winter grazing and water.
Negative_regulation (rely) of SSR
9) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2587706 Disease Relevance 0 Pain Relevance 0
Both guanabenz and UK-14304 also reduced the SSR amplitude (9% +/- 3% of control at 0.4 mg/kg and 11% +/- 6% of control at 0.08 mg/kg, respectively).
Negative_regulation (reduced) of SSR
10) Confidence 0.19 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7714792 Disease Relevance 0.27 Pain Relevance 0.30
Autonomic nerve studies in both patients, including laser Doppler flowmetry (LDF), component analysis of the cardiographic R-R interval and a sympathetic skin response (SSR) test, demonstrated marked abnormalities, such as sensitive vasoconstrictive responses, a suppressed peak of low frequency components and an absence of SSR, respectively, compared with findings in healthy controls.
Negative_regulation (absence) of SSR in sympathetic associated with congenital anomalies
11) Confidence 0.15 Published 1994 Journal Brain Dev. Section Abstract Doc Link 8059932 Disease Relevance 0.25 Pain Relevance 0.17
The combined effect of SSR and image reconstruction improves the CNR in all 10 datasets for HbO2 and HbT, and nine of 10 datasets for HbR.
Negative_regulation (effect) of SSR
12) Confidence 0.13 Published 2010 Journal Frontiers in Neuroenergetics Section Body Doc Link PMC2914577 Disease Relevance 0 Pain Relevance 0.11
Polyneuropathy is associated with “cholinergic” autonomic failure - reduced HRV and absent SSR [14].
Negative_regulation (reduced) of SSR in autonomic associated with neuropathy
13) Confidence 0.13 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2577935 Disease Relevance 0.64 Pain Relevance 0.07
Patients with PNP had reduced HRV and SSR, Parkinson patients had more frequently impaired blood pressure regulation according to PTT assessment.
Negative_regulation (reduced) of SSR in blood associated with neuropathy
14) Confidence 0.13 Published 2008 Journal The Open Neurology Journal Section Abstract Doc Link PMC2577935 Disease Relevance 0.34 Pain Relevance 0
It was concluded that both types of copper IUD were effective for women with previous failure of SSR.
Negative_regulation (failure) of SSR
15) Confidence 0.12 Published 1994 Journal Zhonghua Fu Chan Ke Za Zhi Section Abstract Doc Link 7835121 Disease Relevance 0.26 Pain Relevance 0.09
Cobalt chloride or lidocaine injected in the contralateral paratrigeminal nucleus also attenuated the SSR.
Negative_regulation (attenuated) of SSR in nucleus associated with lidocaine
16) Confidence 0.09 Published 2008 Journal Auton Neurosci Section Abstract Doc Link 18511351 Disease Relevance 0.21 Pain Relevance 0.68
Before surgery, anomalies of M3 SSR were found in 8 hands (40%): M3 SSR was absent in 1 hand; and the M3c/M3 SSR largest area ratio was abnormal in 7 hands, 3 of which also had abnormal mean differences between M3 and M3c SSR latencies.
Negative_regulation (absent) of SSR
17) Confidence 0.08 Published 2001 Journal Muscle Nerve Section Abstract Doc Link 11150978 Disease Relevance 0.44 Pain Relevance 0.44
Succinic semialdehyde reductase (SSR) that catalyzes the reduction of succinic semialdehyde (SSA) to gamma-hydroxybutyrate (GHB) has been identified as one of the NADPH-dependent aldehyde reductases.
Negative_regulation (reduction) of SSR
18) Confidence 0.04 Published 1997 Journal Mol. Cells Section Abstract Doc Link 9085259 Disease Relevance 0 Pain Relevance 0.15
The results show that the cardiovascular responses to stimulus-evoked SSR were inhibited by the presence of a blockade of neuronal conduction in the Gr.
Negative_regulation (inhibited) of SSR in neuronal
19) Confidence 0.02 Published 2002 Journal Brain Res. Section Abstract Doc Link 12470869 Disease Relevance 0.16 Pain Relevance 0.07
The biochemical and pharmacological properties of a novel non-peptide antagonist of the bradykinin (BK) B(1) receptor, SSR240612 [(2R)-2-[((3R)-3-(1,3-benzodioxol-5-yl)-3-[[(6-methoxy-2-naphthyl)sulfonyl]amino]propanoyl)amino]-3-(4-[[2R,6S)-2,6-dimethylpiperidinyl]methyl]phenyl)-N-isopropyl-N-methylpropanamide hydrochloride] were evaluated.
Negative_regulation (antagonist) of SSR240612 associated with antagonist and bradykinin
20) Confidence 0.01 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14747609 Disease Relevance 0 Pain Relevance 0.29

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