INT93101

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Context Info
Confidence 0.62
First Reported 2001
Last Reported 2010
Negated 5
Speculated 6
Reported most in Body
Documents 26
Total Number 32
Disease Relevance 18.45
Pain Relevance 6.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) aging (Bcl2) cell morphogenesis (Bcl2)
endoplasmic reticulum (Bcl2) intracellular (Bcl2) response to stress (Bcl2)
Anatomy Link Frequency
brain 8
NSCs 4
mononuclear cells 4
neck 3
liver 2
Bcl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 26 100.00 Very High Very High Very High
Paracetamol 11 100.00 Very High Very High Very High
Dismenorea 15 99.80 Very High Very High Very High
antidepressant 11 99.68 Very High Very High Very High
fluoxetine 17 99.12 Very High Very High Very High
ischemia 163 99.10 Very High Very High Very High
Glutamate 144 98.48 Very High Very High Very High
Serotonin 4 98.40 Very High Very High Very High
GABAergic 2 95.16 Very High Very High Very High
sSRI 1 93.76 High High
Disease Link Frequency Relevance Heat
Apoptosis 558 100.00 Very High Very High Very High
Dysmenorrhea 15 99.80 Very High Very High Very High
Stress 65 99.28 Very High Very High Very High
Cv Unclassified Under Development 78 99.10 Very High Very High Very High
Cancer 64 98.20 Very High Very High Very High
Chronic Lymphoid Leukemia 123 98.14 Very High Very High Very High
Breast Cancer 8 97.12 Very High Very High Very High
Ocular Hypertension 24 97.08 Very High Very High Very High
Ganglion Cysts 9 96.24 Very High Very High Very High
Endometriosis (extended) 1 96.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In sum, the study results indicate that antidepressant administration can increase NSCs survival, promote the neurite development, and facilitate NSCs differentiating into the functional serotoninergic neurons via the modulation of Bcl-2 expression.
Regulation (modulation) of Gene_expression (expression) of Bcl-2 in NSCs associated with antidepressant
1) Confidence 0.62 Published 2007 Journal Current neurovascular research Section Abstract Doc Link 17311541 Disease Relevance 0.07 Pain Relevance 0.63
In this study we wanted to determine the influence of different NSAIDs (indomethacin, ibuprofen and sodium salicylate) and hydrocortisone on Bcl-2 expression and the apoptotic behavior of head and neck tumor cell lines and normal oral keratinocytes.
Spec (determine) Regulation (influence) of Gene_expression (expression) of Bcl-2 in neck associated with cancer, cinod and apoptosis
2) Confidence 0.61 Published 2001 Journal Acta Otolaryngol. Section Abstract Doc Link 11813903 Disease Relevance 1.00 Pain Relevance 0.35
At all concentrations tested the influence of sodium salicylate and hydrocortisone on Bcl-2 expression was not significant.
Regulation (influence) of Gene_expression (expression) of Bcl-2
3) Confidence 0.61 Published 2001 Journal Acta Otolaryngol. Section Abstract Doc Link 11813903 Disease Relevance 1.01 Pain Relevance 0.37
Effect of developmental A1254 exposure on Bcl2 and Cyp2C11 expression in the brain.
Regulation (Effect) of Gene_expression (expression) of Bcl2 in brain
4) Confidence 0.60 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.07 Pain Relevance 0
In vitro, a decrease in the expression of Bcl-2 has been reported in cultured retinal cells stimulated by various means, including simulated ischemia and excitotoxicity [19], whereas no obvious change in Bcl-2 gene expression was observed in vivo in retinas where ischemia was induced by increased IOP [1].
Neg (no) Regulation (change) of Gene_expression (expression) of Bcl-2 in retinas associated with ischemia and ocular hypertension
5) Confidence 0.56 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.91 Pain Relevance 0.30
Repeated unpredictable stress and antidepressants differentially regulate expression of the bcl-2 family of apoptotic genes in rat cortical, hippocampal, and limbic brain structures.
Regulation (regulate) of Gene_expression (expression) of bcl-2 in brain structures associated with stress, antidepressant and apoptosis
6) Confidence 0.55 Published 2008 Journal Neuropsychopharmacology Section Title Doc Link 17700647 Disease Relevance 0.95 Pain Relevance 0.40
Using microdialysis with high performance liquid chromatography- electrochemical detection, the functional release of serotonin in the differentiating NSCs with FL treatment was increased and simultaneously regulated by the Bcl-2 expressions.
Regulation (regulated) of Gene_expression (expressions) of Bcl-2 in NSCs associated with serotonin and fluoxetine
7) Confidence 0.45 Published 2007 Journal Current neurovascular research Section Abstract Doc Link 17311541 Disease Relevance 0.20 Pain Relevance 0.82
The discrepancies of the results reported on Bcl-2 expression are reinforced by the observation that Bcl-2 peptide administration did not increase retinal ganglion cell survival after optic nerve section but did so after selective ligature of the ophthalmic vessels [23].
Regulation (reported) of Gene_expression (expression) of Bcl-2 in vessels associated with ganglion cysts
8) Confidence 0.41 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.85 Pain Relevance 0.27
The observation that neither the Bax:Bcl-2 nor the Bax:Bcl-xL ratios are regulated at a time when apoptosis is already detectable (3 h) suggests that Bcl-2-related family members are not associated with early cell death following I/R.
Neg (neither) Regulation (regulated) of Gene_expression (ratios) of Bcl-2 associated with apoptosis and death
9) Confidence 0.41 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.56 Pain Relevance 0.07
These same investigators assessed the relationship between clinical response, plasma and intracellular oblimersen levels, and changes in bcl-2 mRNA and Bcl-2 protein levels in bone marrow mononuclear cells in 22 elderly patients treated with oblimersen and chemotherapy for previously untreated acute myeloid leukemia (Marcucci et al 2005).
Regulation (changes) of Gene_expression (levels) of bcl-2 in mononuclear cells associated with leukemia
10) Confidence 0.36 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376092 Disease Relevance 0.22 Pain Relevance 0
These same investigators assessed the relationship between clinical response, plasma and intracellular oblimersen levels, and changes in bcl-2 mRNA and Bcl-2 protein levels in bone marrow mononuclear cells in 22 elderly patients treated with oblimersen and chemotherapy for previously untreated acute myeloid leukemia (Marcucci et al 2005).
Regulation (changes) of Gene_expression (levels) of Bcl-2 in mononuclear cells associated with leukemia
11) Confidence 0.36 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376092 Disease Relevance 0.22 Pain Relevance 0
We examined the brains for expression of bcl-2, which has been shown to be increased in the aged cerebellum.
Spec (examined) Regulation (brains) of Gene_expression (expression) of bcl-2 in brains
12) Confidence 0.35 Published 2001 Journal Microsc. Res. Tech. Section Abstract Doc Link 11514987 Disease Relevance 0.08 Pain Relevance 0.17
We analyzed the changes in neurological severity scores, infarct volume, number of apoptotic neurons, and the expression of G-CSF receptor, phosphorylated signal transducer and activator of transcription 3 (pSTAT3), cellular inhibitor of apoptosis protein 2 (cIAP2), Bcl-2, and Bax in the brain tissue.
Spec (analyzed) Regulation (changes) of Gene_expression (expression) of Bcl-2 in brain associated with apoptosis
13) Confidence 0.32 Published 2008 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 18832793 Disease Relevance 1.95 Pain Relevance 0.17
However, in the Os (75 mg/kg, Fig. 6) group there was no significant change in the expression of Bcl-2 protein and it was found to be comparable to control IR group i.e. 1.80 ± 0.07%.


Neg (no) Regulation (change) of Gene_expression (expression) of Bcl-2 protein
14) Confidence 0.27 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1397864 Disease Relevance 0.46 Pain Relevance 0.07
No significant change in the expression of Bax and Bcl-2 proteins was observed with Os treatment as compared to control IR in the present study.
Neg (No) Regulation (change) of Gene_expression (expression) of Bcl-2
15) Confidence 0.27 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1397864 Disease Relevance 0.55 Pain Relevance 0.07
other techniques to determine the protein expressions of Bax, Bcl-2, and NF-?
Spec (determine) Regulation (determine) of Spec (determine) Gene_expression (expressions) of Bcl-2
16) Confidence 0.26 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234334 Disease Relevance 0.62 Pain Relevance 0.12
In both groups, we observed an irregular pattern of expression each time that we carried out determination of this protein; however, differences in bcl-2 expression for both NaF-treated groups did not present a statistically significant difference among these or as compared with the control group.

4.

Regulation (differences) of Gene_expression (expression) of bcl-2
17) Confidence 0.26 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956113 Disease Relevance 0.06 Pain Relevance 0
CONCLUSION: The protective effect of lithium on the morphine-induced cytotoxicity is mediated via down-regulation of BAX and up-regulation of BCL-2 mRNA expression.


Regulation (regulation) of Gene_expression (expression) of BCL-2 mRNA
18) Confidence 0.24 Published 2008 Journal Arch Iran Med Section Body Doc Link 18976035 Disease Relevance 0 Pain Relevance 0
The most frequent chromosomal deletion identified by fluorescence in situ hybridization in patients with CLL occurs in chromosome 13q14 (Döhner et al 2000). 13q14 deletions eliminate micro RNA (miRNA) regulators of Bcl-2 expression, resulting in enhanced Bcl-2 expression.
Regulation (regulators) of Gene_expression (expression) of Bcl-2 associated with chronic lymphoid leukemia
19) Confidence 0.22 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376092 Disease Relevance 0.63 Pain Relevance 0
In this study we wanted to determine the influence of different NSAIDs (indomethacin, ibuprofen and sodium salicylate) and hydrocortisone on Bcl-2 expression and the apoptotic behavior of head and neck tumor cell lines and normal oral keratinocytes.
Spec (determine) Regulation (influence) of in head Gene_expression (expression) of Bcl-2 in neck associated with cancer, cinod and apoptosis
20) Confidence 0.21 Published 2001 Journal Acta Otolaryngol. Section Abstract Doc Link 11813903 Disease Relevance 1.00 Pain Relevance 0.35

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