INT93109

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Context Info
Confidence 0.80
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Title
Documents 5
Total Number 5
Disease Relevance 3.22
Pain Relevance 2.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NTRK1) endosome (NTRK1) plasma membrane (NTRK1)
Anatomy Link Frequency
nerve 3
neuronal 1
B cells 1
NTRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Trk A 5 100.00 Very High Very High Very High
Hsan 24 99.74 Very High Very High Very High
Nerve growth factor 21 99.72 Very High Very High Very High
Pain 12 89.56 High High
Congenital analgesia 1 75.00 Quite High
reflex sympathetic dystrophy 3 29.20 Quite Low
unmyelinated 6 5.00 Very Low Very Low Very Low
gABA 3 5.00 Very Low Very Low Very Low
Visceral pain 3 5.00 Very Low Very Low Very Low
c fibre 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hereditary Sensory And Autonomic Neuropathies 90 99.74 Very High Very High Very High
Familial Dysautonomia 30 91.76 High High
Hypohidrosis 15 90.56 High High
Pain 12 89.56 High High
Fever 5 79.48 Quite High
Syndrome 5 75.00 Quite High
Injury 8 73.48 Quite High
Stress 5 73.12 Quite High
Disease 9 19.52 Low Low
Cv Unclassified Under Development 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We find that wild-type TRKA precursor proteins in a neuronal and a non-neuronal cell line were differentially processed and phosphorylated in an NGF-dependent and -independent manner, respectively.
Phosphorylation (phosphorylated) of TRKA in neuronal associated with nerve growth factor
1) Confidence 0.80 Published 2001 Journal Hum. Mol. Genet. Section Abstract Doc Link 11159935 Disease Relevance 0.60 Pain Relevance 0.73
In these B cells, NGF failed to induce Trk A phosphorylation, cytoskeleton assembly, or MAP kinase activation.
Phosphorylation (phosphorylation) of Trk in B cells associated with nerve growth factor and trk a
2) Confidence 0.80 Published 2004 Journal J. Clin. Immunol. Section Abstract Doc Link 15163901 Disease Relevance 0.66 Pain Relevance 0.66
Congenital insensitivity to pain with anhidrosis (CIPA): effect of TRKA (NTRK1) missense mutations on autophosphorylation of the receptor tyrosine kinase for nerve growth factor.
Phosphorylation (autophosphorylation) of TRKA in nerve associated with nerve growth factor and hsan
3) Confidence 0.79 Published 2001 Journal Hum. Mol. Genet. Section Title Doc Link 11159935 Disease Relevance 0.64 Pain Relevance 0.78
Congenital insensitivity to pain with anhidrosis (CIPA): effect of TRKA (NTRK1) missense mutations on autophosphorylation of the receptor tyrosine kinase for nerve growth factor.
Phosphorylation (autophosphorylation) of NTRK1 in nerve associated with nerve growth factor and hsan
4) Confidence 0.79 Published 2001 Journal Hum. Mol. Genet. Section Title Doc Link 11159935 Disease Relevance 0.64 Pain Relevance 0.78
This gene encodes for neurotrophic tyrosine kinase receptor type 1 that is autophosphorylated in response to NGF (nerve growth factor) [12].
Phosphorylation (autophosphorylated) of tyrosine kinase receptor type 1 in nerve associated with nerve growth factor
5) Confidence 0.69 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2098750 Disease Relevance 0.68 Pain Relevance 0.05

General Comments

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