INT93110

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Context Info
Confidence 0.03
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 7.98
Pain Relevance 3.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CDCP1) plasma membrane (CDCP1)
Anatomy Link Frequency
neuronal 1
nerve 1
mesenteric lymph nodes 1
platelet 1
lung 1
CDCP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 5 100.00 Very High Very High Very High
Hsan 5 99.80 Very High Very High Very High
Analgesic 1 99.80 Very High Very High Very High
Neurotransmitter 22 99.08 Very High Very High Very High
cINOD 27 98.92 Very High Very High Very High
Pain 21 95.16 Very High Very High Very High
Inflammation 13 89.80 High High
cytokine 6 89.52 High High
Dopamine 24 86.96 High High
central sensitization 2 84.00 Quite High
Disease Link Frequency Relevance Heat
Hereditary Sensory And Autonomic Neuropathies 5 99.80 Very High Very High Very High
Pancreatitis 56 99.70 Very High Very High Very High
Cancer 217 99.48 Very High Very High Very High
Stress 81 99.44 Very High Very High Very High
Breast Cancer 54 99.44 Very High Very High Very High
Disease 120 99.24 Very High Very High Very High
Gastrointestinal Stromal Tumor 17 98.68 Very High Very High Very High
Colon Cancer 5 98.66 Very High Very High Very High
Coronary Artery Disease 66 98.60 Very High Very High Very High
Myeloid Leukemia 29 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We report that in human colorectal carcinoma cells NSAIDs stimulated the three families of MAPK, extracellular regulated kinases, c-Jun N-terminal kinases, p38 MAPK and that this stimulation is prevented by N-acetyl cysteine.
Regulation (regulated) of kinases associated with colon cancer and cinod
1) Confidence 0.03 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 11841790 Disease Relevance 0.36 Pain Relevance 0.65
We report that in human colorectal carcinoma cells NSAIDs stimulated the three families of MAPK, extracellular regulated kinases, c-Jun N-terminal kinases, p38 MAPK and that this stimulation is prevented by N-acetyl cysteine.
Regulation (regulated) of kinases associated with colon cancer and cinod
2) Confidence 0.03 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 11841790 Disease Relevance 0.36 Pain Relevance 0.70
Human TRKA (NTRK1) encodes the receptor tyrosine kinases (RTKs) for nerve growth factor (NGF) and is the gene responsible for congenital insensitivity to pain with anhidrosis (CIPA), an autosomal recessive disorder characterized by a lack of pain sensation and anhidrosis.
Regulation (responsible) of kinases in nerve associated with hypohidrosis, pain, nerve growth factor and hsan
3) Confidence 0.01 Published 2001 Journal Hum. Mol. Genet. Section Abstract Doc Link 11159935 Disease Relevance 0.62 Pain Relevance 0.73
Although protein kinases were not favored as targets for analgesics, studies in the last decade have demonstrated important roles of these kinases in regulating neuronal plasticity and pain sensitization.
Regulation (targets) of kinases in neuronal associated with pain and analgesic
4) Confidence 0.01 Published 2007 Journal Handb Exp Pharmacol Section Abstract Doc Link 17087130 Disease Relevance 1.13 Pain Relevance 1.09
MAP kinases are regulated by a broad range of environmental stimuli, such as growth factors and stress (reviewed in [21]).
Regulation (regulated) of kinases associated with stress
5) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 0.73 Pain Relevance 0
Other proposed mechanisms for possible benefits in SAP have been the regulation of mitogen-activated kinases [8], a decrease in leukocyte-endothelial interaction [30], improved intestinal microcirculation [31], and a decrease in infection of mesenteric lymph nodes [9].
Regulation (regulation) of kinases in mesenteric lymph nodes associated with pancreatitis and infection
6) Confidence 0.00 Published 2010 Journal Crit Care Section Body Doc Link PMC2945119 Disease Relevance 1.14 Pain Relevance 0.16
Src-family kinases are nonreceptor protein tyrosine kinases responsible for signal transduction in many cellular and oncogenic processes.
Regulation (responsible) of kinases
7) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.33 Pain Relevance 0
Estrogens are already implicated in control of SERT and NET function and related disease etiologies.47,104 So while it is now well recognized that these transporters can be regulated by acute and selective responses via kinases and phosphatases, and that estrogens can activate kinases and phosphatases,140,151 it is unknown if estrogens will be one of the initial triggers of phosphoregulation of cellular neurotransmitter machineries, as has been shown for other targets.152,153

Xenoestrogens (nonphysiological estrogens) and their role in women’s mental health

Regulation (regulated) of kinases associated with mental disorders, neurotransmitter and disease
8) Confidence 0.00 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971739 Disease Relevance 0.19 Pain Relevance 0.14
It is also possible that many different kinases controlled by estrogens regulate neurotransmitter transporters.
Spec (possible) Regulation (controlled) of kinases associated with neurotransmitter
9) Confidence 0.00 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971739 Disease Relevance 0.06 Pain Relevance 0.25
Importantly, lessons learned from patients with CML have been applied successfully for the treatment of patients with other disorders where IM has since been found to be active by virtue of its ability to target other kinases, such as c-kit in patients with gastrointestinal stromal tumors.
Regulation (target) of kinases associated with myeloid leukemia and gastrointestinal stromal tumor
10) Confidence 0.00 Published 2010 Journal Biologics : Targets & Therapy Section Abstract Doc Link PMC3010822 Disease Relevance 0.63 Pain Relevance 0
Here, we have shown that PROK1–PROKR1 induces the expression of IL-11 in PROKR1 Ishikawa cells and first trimester decidua via the calcium–calcineurin signalling pathway in a guanine nucleotide-binding protein (Gq/11), extracellular signal-regulated kinases, Ca2+ and calcineurin–nuclear factor of activated T cells dependent manner.
Regulation (regulated) of kinases in T cells
11) Confidence 0.00 Published 2010 Journal Molecular Human Reproduction Section Abstract Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.04
Although current understanding indicates that these other kinases are regulated by different stress stimuli [52], their catalytic domains are homologous.
Regulation (regulated) of kinases associated with stress
12) Confidence 0.00 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.35 Pain Relevance 0
Phase II testing of sunitinib: the National Cancer Institute of Canada Clinical Trials Group IND Program Trials IND.182–185

Sunitinib (SU11248) is an orally bioavailable inhibitor that affects the receptor tyrosine kinases involved in tumour proliferation and angiogenesis, including vascular endothelial growth factor (vegf) receptors 1, 2, 3, and platelet-derived growth factor receptors alpha (pdgfra) and beta (pdgfrb).

Regulation (affects) of kinases in platelet associated with cancer
13) Confidence 0.00 Published 2007 Journal Current Oncology Section Title Doc Link PMC1948864 Disease Relevance 0.74 Pain Relevance 0
Importantly, because viral kinases are the targets of approved and emerging antiviral treatments, cataloging both the common and unique activities of these proteins may help predict or explain successes or failures during antiviral drug development.



Regulation (targets) of kinases
14) Confidence 0.00 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2936540 Disease Relevance 0.11 Pain Relevance 0
We found that the beta and gamma CHPKs, but not the alpha CHPKs, share at least a subset of activities with the cellular cyclin-dependent kinases (Cdks) that are key components of cell cycle regulation.
Regulation (regulation) of kinases
15) Confidence 0.00 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2936540 Disease Relevance 0.20 Pain Relevance 0
In fact, kinases are now targets for lung and breast cancer chemotherapies [2], and importantly, for herpesviral infections as well [3], [4].
Regulation (targets) of kinases in lung associated with breast cancer and infection
16) Confidence 0.00 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2936540 Disease Relevance 0.54 Pain Relevance 0.05
Among these therapies, a class of compounds that has shown great promise is one that targets tyrosine kinases, which are carried by small molecules or monoclonal antibodies.
Regulation (targets) of kinases
17) Confidence 0.00 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2972555 Disease Relevance 0.52 Pain Relevance 0

General Comments

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