INT93120

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 21
Total Number 23
Disease Relevance 8.42
Pain Relevance 3.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)
Anatomy Link Frequency
astrocytes 7
LEK 2
neurons 2
spinal cord 1
microglia 1
Gfap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 21 100.00 Very High Very High Very High
glial activation 13 100.00 Very High Very High Very High
Dorsal horn 42 98.96 Very High Very High Very High
Morphine 65 98.40 Very High Very High Very High
Spinal cord 170 98.28 Very High Very High Very High
qutenza 6 97.12 Very High Very High Very High
intrathecal 22 95.92 Very High Very High Very High
midbrain 18 94.92 High High
Glutamate 30 93.44 High High
Inflammation 67 89.36 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 257 99.78 Very High Very High Very High
Aids-related Complex 4 99.68 Very High Very High Very High
Brain Disease 4 99.60 Very High Very High Very High
Ocular Hypertension 75 99.44 Very High Very High Very High
Ganglion Cysts 38 99.32 Very High Very High Very High
Injury 208 99.22 Very High Very High Very High
Facial Nerve Injuries 6 98.64 Very High Very High Very High
Hypertrophy 16 97.08 Very High Very High Very High
Hydrocephalus 272 93.80 High High
Stress 38 93.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Co-localization of GFAP and GS was observed in the ARC-ME complex.
Localization (localization) of GFAP associated with aids-related complex
1) Confidence 0.78 Published 2004 Journal Neuroreport Section Abstract Doc Link 15076747 Disease Relevance 0.37 Pain Relevance 0.46
Similar distribution of CX3CL1 was observed after CFA, whereas after mSNL, CX3CL1 was not only observed in neurons but also found in astrocytes, as shown by colocalization of CX3CL1 and GFAP.
Localization (colocalization) of GFAP in neurons
2) Confidence 0.73 Published 2005 Journal J Pain Section Abstract Doc Link 15993821 Disease Relevance 0.65 Pain Relevance 0.88
The changes of pain score and systolic pressure were investigated and the activity of AChE, the content of SP and leu-enkephaline (LEK), and the positive index of c-Fos protein and glial fibrillary acidic protein (GFAP) were detected by biochemistry, radio-immunity method and immunohistochemistry, respectively.
Localization (index) of GFAP in LEK
3) Confidence 0.73 Published 2010 Journal Zhongguo Zhen Jiu Section Body Doc Link 20886795 Disease Relevance 0.08 Pain Relevance 0
The changes of pain score and systolic pressure were investigated and the activity of AChE, the content of SP and leu-enkephaline (LEK), and the positive index of c-Fos protein and glial fibrillary acidic protein (GFAP) were detected by biochemistry, radio-immunity method and immunohistochemistry, respectively.
Localization (index) of glial fibrillary acidic protein in LEK
4) Confidence 0.73 Published 2010 Journal Zhongguo Zhen Jiu Section Body Doc Link 20886795 Disease Relevance 0.08 Pain Relevance 0
In the 36d shunted animals, there was a noticeable decrease in relative abundance of GFAP labeled astrocytes in the cortical layers (Fig. 2).
Localization (abundance) of GFAP in astrocytes
5) Confidence 0.72 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1899521 Disease Relevance 0.13 Pain Relevance 0
Immunohistochemistry was used to examine spinal localization of the cytokines, interleukin (IL)-6, IL-10 and glial activation (OX-42 for microglia and anti-glial fibrillary acidic protein for astrocytes).
Spec (examine) Localization (localization) of anti-glial fibrillary acidic protein in astrocytes associated with glial activation and cytokine
6) Confidence 0.69 Published 1997 Journal Eur J Pain Section Abstract Doc Link 15102412 Disease Relevance 0.13 Pain Relevance 0.59
Double labeling with anti-neurofilament antibodies or anti-glial fibrillary acidic protein antibodies localized L-type Ca2+ channels to axons and astrocytes.
Localization (localized) of glial fibrillary acidic protein in astrocytes
7) Confidence 0.68 Published 2001 Journal J. Neurophysiol. Section Abstract Doc Link 11160521 Disease Relevance 0.65 Pain Relevance 0.11
The longer three-week shunt duration also provided a dramatic reduction in the level of GFAP present in both the parietal cortex and the occipital cortices.
Localization (present) of GFAP in parietal cortex
8) Confidence 0.68 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1899521 Disease Relevance 0.20 Pain Relevance 0
Shunting for as little as 6d was effective in reducing the amount of GFAP present in both the parietal and occipital cortices, with the reduction being more dramatic in the occipital cortex.
Localization (present) of GFAP in occipital cortex
9) Confidence 0.68 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1899521 Disease Relevance 0.43 Pain Relevance 0
The number of GFAP and OX42-positive cells present in lumbar spinal cord sections from animals chronically administered intrathecal vehicle (saline) or morphine (15 ?
Localization (number) of GFAP in spinal cord associated with morphine, intrathecal and spinal cord
10) Confidence 0.67 Published 2010 Journal Mol Pain Section Body Doc Link PMC2862024 Disease Relevance 0.22 Pain Relevance 1.01
IF-stained sections (five from each group) were analysed qualitatively regarding co-localisation of GFAP and AQP4, and AQP4 expression in relation to lectin staining, blinded by one observer (ADS).
Localization (localisation) of GFAP
11) Confidence 0.65 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0 Pain Relevance 0.04
On occasion CB1 receptor staining also appeared to co-localize with GFAP, an astrocyte marker (Figure 3).
Localization (localize) of GFAP in astrocyte
12) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0.19 Pain Relevance 0.17
Therefore, we assessed glial injury in response to the diabetic insult by immunolocalization of GFAP.
Localization (immunolocalization) of GFAP associated with diabetes mellitus and injury
13) Confidence 0.60 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2925907 Disease Relevance 1.40 Pain Relevance 0.05
Duplicate series of NF and GFAP immunoreactive sections from the facial nerve injury were stained by cresyl violet (CV) for interalia visualization of Nissl substance.
Localization (series) of GFAP in facial nerve associated with facial nerve injuries
14) Confidence 0.59 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.16 Pain Relevance 0
By contrast, IOP enhanced expression and co-localization of GFAP and AQP4 in optic nerve astrocytes.
Localization (localization) of GFAP in astrocytes associated with ocular hypertension
15) Confidence 0.58 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2559817 Disease Relevance 0.75 Pain Relevance 0
BrdU and GFAP colocalized in cells of the ganglion cell layer, suggesting that they may represent glial cells in proliferation (Figure 2A,B).
Localization (colocalized) of GFAP in glial cells associated with ganglion cysts
16) Confidence 0.58 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 0.51 Pain Relevance 0
AQP4 co-localizes with astrocytic GFAP in both glia limitans and perivascular end feet.
Localization (localizes) of GFAP
17) Confidence 0.53 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.63 Pain Relevance 0
In the dorsal horn, although the great majority of the MIF cells also localized GFAP, indicating they were glial in origin, some cells also showed only MIF staining without GFAP suggesting that MIF could also be localized in neurons (Fig 4B,4C).
Localization (localized) of GFAP in neurons associated with dorsal horn
18) Confidence 0.52 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC184455 Disease Relevance 0.25 Pain Relevance 0.25
The expression of retinal GFAP is unaltered in SHR or WKY rats
Localization (retinal) of GFAP
19) Confidence 0.50 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.15 Pain Relevance 0
Astrocytes were stained with a rabbit polyclonal antibody directed against GFAP (1?
Localization (directed) of GFAP in Astrocytes
20) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0 Pain Relevance 0.06

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