INT93144

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Context Info
Confidence 0.75
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 14.69
Pain Relevance 6.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CCR1) plasma membrane (CCR1) cell-cell signaling (CCR1)
signal transducer activity (CCR1)
Anatomy Link Frequency
monocyte 3
macrophages 2
Blood 1
joints 1
connective tissue 1
CCR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 737 100.00 Very High Very High Very High
dexamethasone 14 99.78 Very High Very High Very High
rheumatoid arthritis 642 99.54 Very High Very High Very High
cytokine 220 99.38 Very High Very High Very High
endometriosis 145 98.48 Very High Very High Very High
Arthritis 83 96.52 Very High Very High Very High
Inflammation 414 94.56 High High
Inflammatory response 16 89.80 High High
cINOD 14 88.40 High High
Inflammatory stimuli 10 75.16 Quite High
Disease Link Frequency Relevance Heat
Leukemia 53 100.00 Very High Very High Very High
Bone Cancer 2 99.86 Very High Very High Very High
Rheumatoid Arthritis 643 99.54 Very High Very High Very High
Ovarian Cancer 255 98.68 Very High Very High Very High
Cancer 527 98.60 Very High Very High Very High
Endometriosis 170 98.48 Very High Very High Very High
Hypersensitivity 15 96.68 Very High Very High Very High
Arthritis 72 96.52 Very High Very High Very High
Adhesions 46 96.44 Very High Very High Very High
Reprotox - General 3 9 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We demonstrated expression of the human RANTES receptors CCR-1 and CCR-5 in U937 cells and peritoneal macrophages.
Gene_expression (expression) of CCR-1 in peritoneal macrophages
1) Confidence 0.75 Published 2001 Journal Mol. Hum. Reprod. Section Abstract Doc Link 11160842 Disease Relevance 0.65 Pain Relevance 0.28
Furthermore, RA monocytes/macrophages express CC chemokine receptors such as CCR1, CCR2, CCR3 and CCR5 [14], illustrating their broad profile of chemokine receptor expression.
Gene_expression (express) of CCR1 in macrophages associated with chemokine and rheumatoid arthritis
2) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.93 Pain Relevance 0.69
These were CCR1, CCR2a, CCR5, CCR7, CCR9, CX3CR1, CXCR1, CXCR2, CXCR4, CXCR5, CXCR6 (STRL33) and Bob (Table 3).
Gene_expression (These) of CCR1
3) Confidence 0.56 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.01 Pain Relevance 0.79
We have found that costimulation with IgE/antigen and CC chemokine ligand 3 (CCL3) enhances degranulation but inhibits chemotaxis of rat basophilic leukaemia (RBL)-2H3 cells expressing human CCR1 (RBL-CCR1 cells).
Gene_expression (expressing) of CCR1 associated with chemokine and leukemia
4) Confidence 0.55 Published 2005 Journal Novartis Found. Symp. Section Abstract Doc Link 16605132 Disease Relevance 0.56 Pain Relevance 0.23
Treatment of the cells with dexamethasone inhibited expression of RANTES mRNA and inhibited secretion of RANTES protein.
Gene_expression (expression) of RANTES mRNA associated with dexamethasone
5) Confidence 0.49 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.41 Pain Relevance 0.26
The Th2-type cytokine IL-10, however, failed to attenuate RANTES mRNA expression but did inhibit secretion of RANTES induced by a combination of IFN-?
Gene_expression (expression) of RANTES mRNA associated with cytokine
6) Confidence 0.49 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.34 Pain Relevance 0.20
Here, we show comparative data of protein profiles derived from FcepsilonRI-engaged and/or CCR1-engaged RBL-CCR1 cells using protein chip array technology, a proteomic technology.
Gene_expression (engaged) of CCR1 associated with leukemia
7) Confidence 0.48 Published 2005 Journal Novartis Found. Symp. Section Abstract Doc Link 16605132 Disease Relevance 0.64 Pain Relevance 0.26
More recently, the analysis of ovarian cancer ascitic fluid and ascite cells allowed the identification of the expression of CCL2,-3,-4,-5,-8, and -22, altogether with their receptors (namely, CCR1, -2a,-2b, -3,-4,-5, and-8), at mRNA and protein level [71].
Gene_expression (expression) of CCR1 associated with ovarian cancer
8) Confidence 0.45 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.13 Pain Relevance 0.24
In EOC ascitic fluid and blood of patients the reduction of migration responses of monocyte/macrophages expressing several chemokine receptors (CCR1, CCR5, and CXCR4) produced in the tumor microenvironment, has been described [79].
Gene_expression (expressing) of CCR1 in macrophages associated with chemokine and cancer
9) Confidence 0.45 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.10 Pain Relevance 0.20
We have found that costimulation with IgE/antigen and CC chemokine ligand 3 (CCL3) enhances degranulation but inhibits chemotaxis of rat basophilic leukaemia (RBL)-2H3 cells expressing human CCR1 (RBL-CCR1 cells).
Gene_expression (expressing) of CCR1 associated with chemokine and leukemia
10) Confidence 0.43 Published 2005 Journal Novartis Found. Symp. Section Abstract Doc Link 16605132 Disease Relevance 0.57 Pain Relevance 0.24
A recent study showed that CCL16 stimulated cell migration of human osteogenic sarcoma cells expressing CCR1 [39].
Gene_expression (expressing) of CCR1 associated with bone cancer
11) Confidence 0.27 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.75 Pain Relevance 0.25
Blood PDCs express many different chemokine receptors including CCR2, CCR5, CCR6, CCR7, CXCR3, and CXCR4 [40], whereas MDC express CCR1, CCR2, CCR3, CCR5, CCR6, CCR7 and CCR8 [19], [20], [21].
Gene_expression (express) of CCR1 in Blood associated with chemokine
12) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.23 Pain Relevance 0.14
Cytokine or cytokine receptor patterns showed high expression of CCR1, FGFR1, connective tissue growth factor (CTGF), FGF7, and SCYA19 in biopsies from SSC patients.
Gene_expression (expression) of CCR1 in connective tissue associated with hypersensitivity and cytokine
13) Confidence 0.25 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.11 Pain Relevance 0.10
Furthermore, RA monocytes/macrophages express CC chemokine receptors such as CCR1, CCR2, CCR3 and CCR5 [14], illustrating their broad profile of chemokine receptor expression.
Gene_expression (express) of CCR1 in monocytes associated with chemokine and rheumatoid arthritis
14) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.93 Pain Relevance 0.69
express only select types of the numerous chemokine receptors (for example, CCR1, 2, 5, 7, and 8 as well as CX3CR1), representing a partially specific basis for prominent trafficking of monocyte/M?
Gene_expression (express) of CCR1 in monocyte associated with chemokine
15) Confidence 0.17 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 0.97 Pain Relevance 0.85
In EOC ascitic fluid and blood of patients the reduction of migration responses of monocyte/macrophages expressing several chemokine receptors (CCR1, CCR5, and CXCR4) produced in the tumor microenvironment, has been described [79].
Gene_expression (expressing) of CCR1 in monocyte associated with chemokine and cancer
16) Confidence 0.15 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.10 Pain Relevance 0.20
The invasive trophoblast and the eutopic endometrium strongly express chemokine receptors (CCR1, CCR10, CCR5, CCR7, CXCR4, CXCR6 and XCR) and chemokines contribute to the positioning, adhesion and migration of trophoblast [55-58].
Gene_expression (express) of CCR1 in endometrium associated with chemokine and adhesions
17) Confidence 0.14 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 1.14 Pain Relevance 0.63
/CXCL1 levels and enhanced CCR-1, CCR-2, CCR-5, and CXCR1 receptor expression in the joints of GTE-administered rats [38].
Gene_expression (expression) of CCR-1 in joints
18) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 1.13 Pain Relevance 0.59

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