INT93165

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 32
Total Number 37
Disease Relevance 12.49
Pain Relevance 5.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (TRPV2) plasma membrane (TRPV2) intracellular (TRPV2)
cytoplasm (TRPV2)
Anatomy Link Frequency
liver 3
blood 2
dorsal root ganglia 2
anterior 1
autonomic nervous system 1
TRPV2 (Homo sapiens)
Pain Link Frequency Relevance Heat
nociceptor 21 99.20 Very High Very High Very High
addiction 8 99.08 Very High Very High Very High
agonist 35 98.90 Very High Very High Very High
Neuropeptide 7 98.20 Very High Very High Very High
Calcitonin gene-related peptide 8 97.64 Very High Very High Very High
substance P 10 97.28 Very High Very High Very High
Pain 93 97.04 Very High Very High Very High
Inflammation 39 96.76 Very High Very High Very High
qutenza 118 96.36 Very High Very High Very High
imagery 4 95.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Manic Depressive Disorder 6 99.92 Very High Very High Very High
Hepatocellular Cancer 72 99.76 Very High Very High Very High
Cirrhosis 27 99.52 Very High Very High Very High
Chronic Hepatitis 18 99.00 Very High Very High Very High
Liver Cancer 2 98.88 Very High Very High Very High
Cancer 18 97.56 Very High Very High Very High
Nociception 16 97.36 Very High Very High Very High
Neuropathic Pain 11 97.32 Very High Very High Very High
Pain 80 97.04 Very High Very High Very High
INFLAMMATION 45 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemistry of the 55 HCC samples showed that the expression of TRPV2 increased when going from normal liver or chronic hepatitis to cirrhosis.
Gene_expression (expression) of TRPV2 in liver associated with chronic hepatitis, cirrhosis and hepatocellular cancer
1) Confidence 0.78 Published 2010 Journal Cancer Genet. Cytogenet. Section Abstract Doc Link 20113837 Disease Relevance 1.40 Pain Relevance 0.09
To investigate its role in hepatocarcinogenesis, we examined the expression of TRPV2 in human hepatocellular carcinoma (HCC) samples and analyzed the association of TRPV2 expression with its clinical significance.
Spec (examined) Gene_expression (expression) of TRPV2 associated with hepatocellular cancer
2) Confidence 0.78 Published 2010 Journal Cancer Genet. Cytogenet. Section Abstract Doc Link 20113837 Disease Relevance 0.78 Pain Relevance 0.14
Clinicopathologic assessment suggested a significant association between TRPV2 expression and portal vein invasion and histopathologic differentiation (P = 0.036 and 0.001, respectively).
Gene_expression (expression) of TRPV2 in portal vein
3) Confidence 0.78 Published 2010 Journal Cancer Genet. Cytogenet. Section Abstract Doc Link 20113837 Disease Relevance 1.09 Pain Relevance 0
TRPV2 expression in 55 HCC patients was examined by immunohistochemistry, and the correlation between TRPV2 levels and clinicopathologic parameters was analyzed.
Gene_expression (expression) of TRPV2 associated with hepatocellular cancer
4) Confidence 0.78 Published 2010 Journal Cancer Genet. Cytogenet. Section Abstract Doc Link 20113837 Disease Relevance 0.90 Pain Relevance 0.14
In HCC, increased expression of TRPV2 was identified in 16/55 (29%) cases.
Gene_expression (expression) of TRPV2 associated with hepatocellular cancer
5) Confidence 0.78 Published 2010 Journal Cancer Genet. Cytogenet. Section Abstract Doc Link 20113837 Disease Relevance 1.32 Pain Relevance 0.08
Quantitative RT-PCR and Western blotting analysis revealed that expression of TRPV2 at both the mRNA and protein levels were increased in cirrhotic livers compared with chronic hepatitis, whereas that also occurred in moderately and well-differentiated tumors compared with that of poorly differentiated tumors.
Gene_expression (expression) of TRPV2 in livers associated with chronic hepatitis, cirrhosis and cancer
6) Confidence 0.78 Published 2010 Journal Cancer Genet. Cytogenet. Section Abstract Doc Link 20113837 Disease Relevance 1.36 Pain Relevance 0.11
To investigate its role in hepatocarcinogenesis, we examined the expression of TRPV2 in human hepatocellular carcinoma (HCC) samples and analyzed the association of TRPV2 expression with its clinical significance.
Spec (analyzed) Gene_expression (expression) of TRPV2 associated with hepatocellular cancer
7) Confidence 0.78 Published 2010 Journal Cancer Genet. Cytogenet. Section Abstract Doc Link 20113837 Disease Relevance 0.85 Pain Relevance 0.14
Increased TRPV2 expression was observed in tissues of liver cirrhosis (31/37, 83.8%).
Gene_expression (expression) of TRPV2 in liver associated with cirrhosis
8) Confidence 0.78 Published 2010 Journal Cancer Genet. Cytogenet. Section Abstract Doc Link 20113837 Disease Relevance 1.37 Pain Relevance 0.09
Unlike VR1 and VRL-1, VRL-2 was not detected in cell bodies of dorsal root ganglia (DRG) or sensory nerve fibers.
Neg (not) Gene_expression (detected) of VRL-2 in dorsal root ganglia
9) Confidence 0.77 Published 2001 Journal Physiol. Genomics Section Abstract Doc Link 11160995 Disease Relevance 0.08 Pain Relevance 0.07
VRL-2 mRNA was most strongly expressed in the trachea, kidney, and salivary gland.
Gene_expression (expressed) of VRL-2 mRNA in salivary gland
10) Confidence 0.77 Published 2001 Journal Physiol. Genomics Section Abstract Doc Link 11160995 Disease Relevance 0.10 Pain Relevance 0.08
Unlike VR1 and VRL-1, VRL-2 was not detected in cell bodies of dorsal root ganglia (DRG) or sensory nerve fibers.
Neg (not) Gene_expression (detected) of VRL-1 in dorsal root ganglia
11) Confidence 0.77 Published 2001 Journal Physiol. Genomics Section Abstract Doc Link 11160995 Disease Relevance 0.08 Pain Relevance 0.07
Using qRT-PCR, TRPV2 mRNA was highly expressed in human whole blood isolates (9.33+/-1.19 x 10(4)copies per 10(6)copies of the housekeeping gene GAPDH), whereas TRPV1 message was detected at approximately 150-fold lower levels (638+/-121 copies per 10(6)copies GAPDH).
Gene_expression (expressed) of TRPV2 mRNA in blood
12) Confidence 0.77 Published 2007 Journal Mol. Immunol. Section Abstract Doc Link 16777226 Disease Relevance 0 Pain Relevance 0.08
Expression of transient receptor potential vanilloid 1 (TRPV1) and 2 (TRPV2) in human peripheral blood.
Gene_expression (Expression) of TRPV2 in blood
13) Confidence 0.77 Published 2007 Journal Mol. Immunol. Section Title Doc Link 16777226 Disease Relevance 0 Pain Relevance 0.10
The present study demonstrates both gene and protein expression of TRPV1 and TRPV2 in human peripheral blood cells (PBCs) using molecular and immunocytochemical techniques.
Gene_expression (expression) of TRPV2 in blood cells
14) Confidence 0.77 Published 2007 Journal Mol. Immunol. Section Abstract Doc Link 16777226 Disease Relevance 0 Pain Relevance 0.09
Activation properties of heterologously expressed mammalian TRPV2: evidence for species dependence.
Gene_expression (expressed) of TRPV2 associated with addiction and nociceptor
15) Confidence 0.75 Published 2007 Journal J. Biol. Chem. Section Title Doc Link 17395593 Disease Relevance 0.10 Pain Relevance 0.41
By contrast, expression of human TRPV2 did not lead to detectable activation by either of these stimuli.
Gene_expression (expression) of TRPV2
16) Confidence 0.75 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17395593 Disease Relevance 0.07 Pain Relevance 0.27
Human TRPV2 protein was expressed at levels comparable with those of rat TRPV2, exhibited similar surface localization and responded to a novelly identified TRPV2 agonist, Delta(9)-tetrahydrocannabinol, indicating that human TRPV2 is functionally expressed on the cell surface.
Gene_expression (expressed) of TRPV2 associated with agonist
17) Confidence 0.75 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17395593 Disease Relevance 0.06 Pain Relevance 0.24
Here, we report the expression of rat, mouse, and human TRPV2 in HEK293 cells and the differential properties of their responses to heat and 2-APB.
Gene_expression (expression) of TRPV2
18) Confidence 0.75 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17395593 Disease Relevance 0.08 Pain Relevance 0.28
Expression of mouse or rat TRPV2 in HEK293 cells resulted in robust channel activation when induced by either temperature (>53 degrees C) or 2-APB.
Gene_expression (Expression) of TRPV2
19) Confidence 0.75 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17395593 Disease Relevance 0.08 Pain Relevance 0.28
Human TRPV2 protein was expressed at levels comparable with those of rat TRPV2, exhibited similar surface localization and responded to a novelly identified TRPV2 agonist, Delta(9)-tetrahydrocannabinol, indicating that human TRPV2 is functionally expressed on the cell surface.
Gene_expression (expressed) of TRPV2 associated with agonist
20) Confidence 0.75 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17395593 Disease Relevance 0.07 Pain Relevance 0.26

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