INT93168

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Context Info
Confidence 0.63
First Reported 2001
Last Reported 2010
Negated 8
Speculated 0
Reported most in Abstract
Documents 24
Total Number 24
Disease Relevance 17.18
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ttf1) DNA binding (Ttf1)
Anatomy Link Frequency
thyroid 4
neuronal 3
Merkel cell 2
lung 2
smooth muscle 1
Ttf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 12 100.00 Very High Very High Very High
imagery 13 93.72 High High
Bile 10 89.84 High High
Pain 13 80.16 Quite High
abdominal pain 8 78.96 Quite High
positron emission tomography 1 74.40 Quite High
Angina 3 66.76 Quite High
Thoracotomy 1 64.56 Quite High
nud 1 49.44 Quite Low
pain flank 1 47.60 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 3 100.00 Very High Very High Very High
Merkel Cell Carcinoma 41 99.78 Very High Very High Very High
Precocious Puberty 6 99.38 Very High Very High Very High
Small Cell Lung Cancer 175 99.20 Very High Very High Very High
Disease 72 99.08 Very High Very High Very High
Cancer 235 98.82 Very High Very High Very High
Adenocarcinoma 147 98.80 Very High Very High Very High
Metastasis 100 97.00 Very High Very High Very High
Nicotine Addiction 3 96.48 Very High Very High Very High
Neuroendocrine Cancer 38 95.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We now report that postnatal hypothalamic TTF-1 expression is developmentally regulated and associated with the neuroendocrine process of female sexual development.
Gene_expression (expression) of TTF-1
1) Confidence 0.63 Published 2001 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 11161473 Disease Relevance 0.09 Pain Relevance 0
The singular increase in hypothalamic TTF-1 gene expression that precedes the initiation of puberty, its highly specific pattern of cellular expression, and its transcriptional actions on genes directly involved in neuroendocrine reproductive regulation suggest that TTF-1 may represent one of the controlling factors that set in motion early events underlying the central activation of mammalian puberty.
Gene_expression (expression) of TTF-1 gene
2) Confidence 0.63 Published 2001 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 11161473 Disease Relevance 0.07 Pain Relevance 0
Postnatal expression of the TTF-1 gene was limited to subsets of hypothalamic neurons, including LHRH neurons, which control sexual maturation, and preproenkephalinergic neurons of the lateroventromedial nucleus of the basal hypothalamus, which restrain sexual maturation and facilitate reproductive behavior.
Gene_expression (expression) of TTF-1 gene in nucleus
3) Confidence 0.63 Published 2001 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 11161473 Disease Relevance 0.09 Pain Relevance 0
TTF-1, a homeodomain gene required for diencephalic morphogenesis, is postnatally expressed in the neuroendocrine brain in a developmentally regulated and cell-specific fashion.
Gene_expression (expressed) of TTF-1 in brain associated with enkephalin
4) Confidence 0.63 Published 2001 Journal Mol. Cell. Neurosci. Section Title Doc Link 11161473 Disease Relevance 0.08 Pain Relevance 0.20
Lesions of the hypothalamus that cause sexual precocity transiently activate neuronal TTF-1 expression near the lesion site.
Gene_expression (expression) of TTF-1 in neuronal associated with precocious puberty
5) Confidence 0.63 Published 2001 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 11161473 Disease Relevance 0.10 Pain Relevance 0
TTF-1 mRNA was also detected in astrocytes of the median eminence and ependymal/subependymal cells of the third ventricle, where it colocalized with erbB-2, a receptor involved in facilitating sexual development.
Gene_expression (detected) of TTF-1 mRNA in median eminence
6) Confidence 0.49 Published 2001 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 11161473 Disease Relevance 0.08 Pain Relevance 0
The finding from previous studies that expression of several transcription factors involved in regulating proximal/distal epithelial cell differentiation in the lung, including TTF-1, Foxa1, Foxa2, and ?
Gene_expression (expression) of TTF-1 in lung
7) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Another study reported that TTF-1 was expressed in 82.7% of pulmonary SmCCs, 42.0% of extra-pulmonary SmCCs (range, 33.3 – 53.3% for the various sites), and 0% of Merkel cell carcinomas [26].
Gene_expression (expressed) of TTF-1 in Merkel cell associated with carcinoma
8) Confidence 0.07 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC2034542 Disease Relevance 1.01 Pain Relevance 0
Thyroid transcription factor-1 (TTF-1) is a nuclear homeodomain transcription factor that is expressed in the developing thyroid, respiratory epithelium, and diencephalon [26].
Gene_expression (expressed) of TTF-1 in thyroid
9) Confidence 0.07 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC2034542 Disease Relevance 1.03 Pain Relevance 0
TTF-1 and WT-1 were negative in all cases examined.
Neg (negative) Gene_expression (negative) of TTF-1
10) Confidence 0.07 Published 2007 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 17895755 Disease Relevance 0.92 Pain Relevance 0
With relatively limited data, staining for TTF-1 seems to be uniformly negative in CRSmCC.[29] The results of our study support this observation highlighting the value of TTF-1 immunostaining in differentiating SmCC of a colorectal from that of a pulmonary origin.
Gene_expression (immunostaining) of TTF-1 associated with small cell lung cancer
11) Confidence 0.06 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC2034542 Disease Relevance 1.02 Pain Relevance 0
The importance of TTF-1 is to exclude metastatic Merkel cell carcinoma, which is TTF-1 negative [11].
Neg (negative) Gene_expression (negative) of TTF-1 in Merkel cell associated with merkel cell carcinoma
12) Confidence 0.06 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2241597 Disease Relevance 1.22 Pain Relevance 0
Higher proportion of positive labeling of NSE, Syn, AE1/AE3, CD56, TTF-1, and CgA in PESCC was valuably applied in diagnosis and differential diagnosis.
Gene_expression (positive) of TTF-1
13) Confidence 0.06 Published 2010 Journal Dis. Esophagus Section Abstract Doc Link 19515193 Disease Relevance 0.67 Pain Relevance 0.12
In the reported case TTF-1 turned out to be negative.
Neg (negative) Gene_expression (negative) of TTF-1
14) Confidence 0.06 Published 2008 Journal Head Face Med Section Body Doc Link PMC2515301 Disease Relevance 1.52 Pain Relevance 0
The thyroid transcription factor 1 (TTF-1) is a specific marker of the thyroid gland and the epithelia of the lung, regulating the expression of surfactant in the latter organ [14,15].
Gene_expression (expression) of TTF-1 in thyroid
15) Confidence 0.06 Published 2008 Journal Head Face Med Section Body Doc Link PMC2515301 Disease Relevance 1.48 Pain Relevance 0
TTF-1, TTF-2, Pax-8, Na-I symporter and thyroid peroxidase mRNA were detected.
Gene_expression (detected) of TTF-1 in thyroid
16) Confidence 0.06 Published 2002 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 12354139 Disease Relevance 0.97 Pain Relevance 0.07
Immunohistochemical staining of chromogranin A (CgA), neuron-specific enolase (NSE), synaptophysin (Syn), neuronal cell adhesion molecules (CD56), thyroid transcription factor-1 (TTF-1), cytokeration 34betaE12 (CK34betaE12), cytokeratin (AE1/AE3), and cytokeratin 10/13 was performed.
Gene_expression (/) of TTF-1 in neuronal associated with adhesions
17) Confidence 0.05 Published 2010 Journal Dis. Esophagus Section Abstract Doc Link 19515193 Disease Relevance 0.87 Pain Relevance 0.16
Immunohistochemical staining of chromogranin A (CgA), neuron-specific enolase (NSE), synaptophysin (Syn), neuronal cell adhesion molecules (CD56), thyroid transcription factor-1 (TTF-1), cytokeration 34betaE12 (CK34betaE12), cytokeratin (AE1/AE3), and cytokeratin 10/13 was performed.
Gene_expression (staining) of TTF-1 in neuronal associated with adhesions
18) Confidence 0.05 Published 2010 Journal Dis. Esophagus Section Abstract Doc Link 19515193 Disease Relevance 0.89 Pain Relevance 0.15
Despite TTF-1 being negative, the diagnosis of metastatic adenocarcinoma of the lung was made due to the history of smoking and radiological pattern of disease.
Neg (negative) Gene_expression (negative) of TTF-1 in lung associated with adenocarcinoma, nicotine addiction and disease
19) Confidence 0.05 Published 2008 Journal Cases J Section Body Doc Link PMC2526067 Disease Relevance 0.96 Pain Relevance 0.09
Lymphatic Common Antigen (LCA), Thyroid Transcription Factor – 1 (TTF-1) and CD99 were negative.
Neg (negative) Gene_expression (negative) of TTF-1 in Thyroid
20) Confidence 0.05 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2279132 Disease Relevance 0.67 Pain Relevance 0.07

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