INT93169

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Context Info
Confidence 0.30
First Reported 2001
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.04
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ttf1) DNA binding (Ttf1)
Anatomy Link Frequency
thyroid 1
Ttf1 (Mus musculus)
Pain Link Frequency Relevance Heat
colic 1 50.80 Quite High
Inflammation 3 42.76 Quite Low
Enkephalin 2 25.00 Low Low
palliative 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Paresthesia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 46 98.88 Very High Very High Very High
Adenocarcinoma 56 95.44 Very High Very High Very High
Metastasis 17 95.08 Very High Very High Very High
Salivary Gland Disease 11 92.72 High High
Small Cell Lung Cancer 33 82.12 Quite High
Adenoma 5 80.40 Quite High
Precocious Puberty 1 71.64 Quite High
Apoptosis 2 64.88 Quite High
Abdominal Cramps 1 50.80 Quite High
Inflammatory Bowel Disease 3 43.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TTF-1 binds to and transactivates the erbB-2 and LHRH promoters, but represses transcription of the preproenkephalin gene.
TTF-1 Binding (binds) of
1) Confidence 0.30 Published 2001 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 11161473 Disease Relevance 0.07 Pain Relevance 0
Our immunohistochemical panel showed that all cases were positive for low molecular weight cytokeratin (LMWK), CK 19 and pancytokeratin but were negative for TTF-1 and CA 125.
TTF-1 Binding (negative) of
2) Confidence 0.03 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC2034542 Disease Relevance 0.82 Pain Relevance 0.03
A lung primary was unlikely as the tumour was characterized by positivity for cytokeratin 20 and negativity for the thyroid transcription factor-1 protein (TTF-1) in immunohistochemistry.


TTF-1 Neg (negativity) Binding (negativity) of in thyroid associated with cancer
3) Confidence 0.03 Published 2008 Journal Head Face Med Section Abstract Doc Link PMC2515301 Disease Relevance 1.15 Pain Relevance 0

General Comments

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