INT93171

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Context Info
Confidence 0.57
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0.32
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ttf1) DNA binding (Ttf1)
Anatomy Link Frequency
neuronal 2
nucleus 2
Ttf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 8 25.00 Low Low
Disease Link Frequency Relevance Heat
Precocious Puberty 4 99.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The singular increase in hypothalamic TTF-1 gene expression that precedes the initiation of puberty, its highly specific pattern of cellular expression, and its transcriptional actions on genes directly involved in neuroendocrine reproductive regulation suggest that TTF-1 may represent one of the controlling factors that set in motion early events underlying the central activation of mammalian puberty.
Positive_regulation (increase) of Gene_expression (expression) of TTF-1 gene
1) Confidence 0.57 Published 2001 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 11161473 Disease Relevance 0.07 Pain Relevance 0
Lesions of the hypothalamus that cause sexual precocity transiently activate neuronal TTF-1 expression near the lesion site.
Positive_regulation (activate) of Gene_expression (expression) of TTF-1 in neuronal associated with precocious puberty
2) Confidence 0.57 Published 2001 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 11161473 Disease Relevance 0.10 Pain Relevance 0
Postnatal expression of the TTF-1 gene was limited to subsets of hypothalamic neurons, including LHRH neurons, which control sexual maturation, and preproenkephalinergic neurons of the lateroventromedial nucleus of the basal hypothalamus, which restrain sexual maturation and facilitate reproductive behavior.
Positive_regulation (limited) of Gene_expression (expression) of TTF-1 gene in nucleus
3) Confidence 0.41 Published 2001 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 11161473 Disease Relevance 0.09 Pain Relevance 0
The singular increase in hypothalamic TTF-1 gene expression that precedes the initiation of puberty, its highly specific pattern of cellular expression, and its transcriptional actions on genes directly involved in neuroendocrine reproductive regulation suggest that TTF-1 may represent one of the controlling factors that set in motion early events underlying the central activation of mammalian puberty.
Positive_regulation (precedes) of Gene_expression (expression) of TTF-1 gene
4) Confidence 0.41 Published 2001 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 11161473 Disease Relevance 0.07 Pain Relevance 0

General Comments

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