INT9318

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Context Info
Confidence 0.32
First Reported 1992
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.39
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igfbp1) extracellular region (Igfbp1)
Igfbp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 180 99.66 Very High Very High Very High
anesthesia 6 96.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cleidocranial Dysplasia 12 95.60 Very High Very High Very High
Bronchopulmonary Dysplasia 40 95.16 Very High Very High Very High
Body Weight 17 87.28 High High
Intrauterine Growth Retardation 8 82.40 Quite High
Birth Weight 4 71.64 Quite High
Pulmonary Disease 12 55.36 Quite High
Hypertrophic Cardiomyopathy 4 45.96 Quite Low
Metabolic Disorder 8 44.80 Quite Low
Weight Gain 12 44.48 Quite Low
Paresis 4 43.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dexamethasone seems to induce IGFBP-1 secretion with a latency of some weeks after application.
Localization (secretion) of IGFBP-1 associated with dexamethasone
1) Confidence 0.32 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721283 Disease Relevance 0.20 Pain Relevance 0.27
It remains to speculate that Huysman’s data reflect only a very short term effect of the steroids on the IGFBP-1 secretion, whereas our findings integrate a longer and more sustainable effect.
Localization (secretion) of IGFBP-1
2) Confidence 0.32 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721283 Disease Relevance 0.23 Pain Relevance 0.16
IGFBP-1 mRNA secretion was induced by glucocorticoids in different animal models by various pathways (Luo et al 1990; Suwanichkul et al 1994; Suh et al 1995; Suh and Rechler 1997; Uchijima et al 1999; Lewitt 2001; Gan et al 2005).


Localization (secretion) of IGFBP-1
3) Confidence 0.28 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721283 Disease Relevance 0.22 Pain Relevance 0.31
IGFBP-1 secretion was significantly enhanced by dexamethasone treatment, both in the infants with or without broncho-pulmonary dysplasia (BPD).
Localization (secretion) of IGFBP-1 associated with cleidocranial dysplasia, bronchopulmonary dysplasia and dexamethasone
4) Confidence 0.28 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721283 Disease Relevance 0.42 Pain Relevance 0.21
As assessed by solution hybridization, UA-lig fetuses exhibited significantly higher hepatic IGFBP-1, IGFBP-2, and IGF-II transcript abundance than UA-nonlig controls (increased 110, 50, and 31%, respectively).
Localization (abundance) of IGFBP-1
5) Confidence 0.24 Published 1992 Journal Pediatr. Res. Section Abstract Doc Link 1408464 Disease Relevance 0.32 Pain Relevance 0.17

General Comments

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