INT9319

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Context Info
Confidence 0.80
First Reported 1992
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.13
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Igfbp2) extracellular space (Igfbp2) aging (Igfbp2)
extracellular region (Igfbp2) response to stress (Igfbp2)
Anatomy Link Frequency
chondrocytes 1
hypothalamus 1
lamellar bone 1
portal vein 1
shaft 1
Igfbp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 3 99.00 Very High Very High Very High
ischemia 7 97.50 Very High Very High Very High
medulla 6 96.88 Very High Very High Very High
anesthesia 9 95.84 Very High Very High Very High
agonist 2 93.16 High High
narcan 1 88.80 High High
antagonist 11 81.48 Quite High
Opioid 1 81.04 Quite High
MU agonist 2 75.00 Quite High
isoflurane 6 74.60 Quite High
Disease Link Frequency Relevance Heat
Sepsis 38 98.68 Very High Very High Very High
Cv Unclassified Under Development 5 97.50 Very High Very High Very High
Hypoxia 5 97.32 Very High Very High Very High
Body Weight 1 86.92 High High
Intrauterine Growth Retardation 4 81.24 Quite High
Injury 13 72.28 Quite High
Bordatella Infection 3 69.96 Quite High
Osteoporosis 3 63.60 Quite High
Diuresis 1 60.68 Quite High
INFLAMMATION 12 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of this study, therefore, was to determine the localization of IGFBP-2 mRNA in the cortical tibial shaft after mechanical stimulation.
Spec (determine) Localization (localization) of IGFBP-2 mRNA in shaft
1) Confidence 0.80 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0.06 Pain Relevance 0
In the internal control, i.e., the growth plate, IGFBP-2 mRNA was located in chondrocytes of the proliferative and hypertrophic zone (Fig. 1C).
Localization (located) of IGFBP-2 mRNA in chondrocytes
2) Confidence 0.75 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0 Pain Relevance 0.05
This suggests that IGFBP-2 mRNA in the mechanosensitive osteocytes is specifically important for lamellar bone formation.
Localization (important) of IGFBP-2 mRNA in lamellar bone
3) Confidence 0.75 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0 Pain Relevance 0
The data demonstrate that BRL is a potent inhibitor of osmotically stimulated AVP secretion via activation of kappa-opiate receptors within the hypothalamus, but that higher concentrations of the drug may also stimulate non-kappa-neurohypophysial opiate receptors that suppress AVP release.
Localization (secretion) of BRL in hypothalamus associated with opiate
4) Confidence 0.57 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8779961 Disease Relevance 0.06 Pain Relevance 0.67
In a later study with the same hypoxia-ischemia model and intraventricular infusion protocol, Guan et al [38] investigated the cellular distribution of 3H-IGF-1 and its co-localization with immunoreactive IGFBP-2 at 30 min and 6 hr after administration.
Localization (localization) of IGFBP-2 associated with hypoxia and ischemia
5) Confidence 0.37 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1190198 Disease Relevance 0.44 Pain Relevance 0.12
As assessed by solution hybridization, UA-lig fetuses exhibited significantly higher hepatic IGFBP-1, IGFBP-2, and IGF-II transcript abundance than UA-nonlig controls (increased 110, 50, and 31%, respectively).
Localization (abundance) of IGFBP-2
6) Confidence 0.20 Published 1992 Journal Pediatr. Res. Section Abstract Doc Link 1408464 Disease Relevance 0.32 Pain Relevance 0.17
A third group also received BRL-44408 maleate (1 mM solution at 13 µl/min), which was first infused into the portal vein for 15 min and then followed by infusion of 20 µM NE in combination with 1 mM BRL-44408 for 2 h at an infusion rate of 13 µl/min.
Localization (maleate) of BRL-44408 in portal vein
7) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677660 Disease Relevance 0.25 Pain Relevance 0.15

General Comments

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