INT93191

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Context Info
Confidence 0.76
First Reported 2001
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 22
Total Number 24
Disease Relevance 10.04
Pain Relevance 8.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn2) plasma membrane (Accn2)
Anatomy Link Frequency
dorsal root ganglia 5
epithelium 3
muscle 2
neurons 2
plasma 1
Accn2 (Mus musculus)
Pain Link Frequency Relevance Heat
ASIC 95 100.00 Very High Very High Very High
PcTx1 5 100.00 Very High Very High Very High
tetrodotoxin 1 100.00 Very High Very High Very High
trigeminal ganglion 3 99.68 Very High Very High Very High
Central nervous system 1 99.68 Very High Very High Very High
Mechanosensation 9 99.64 Very High Very High Very High
Hyperalgesia 40 99.60 Very High Very High Very High
Peripheral nervous system 15 99.52 Very High Very High Very High
Pain 42 99.48 Very High Very High Very High
Inflammation 49 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acidosis 26 99.92 Very High Very High Very High
Nociception 8 99.84 Very High Very High Very High
Ganglion Cysts 15 99.68 Very High Very High Very High
Hyperalgesia 40 99.60 Very High Very High Very High
Pain 38 99.48 Very High Very High Very High
INFLAMMATION 43 99.28 Very High Very High Very High
Targeted Disruption 3 97.36 Very High Very High Very High
Infection 3 92.88 High High
Inflammatory Pain 12 92.80 High High
Cv Unclassified Under Development 2 92.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PERSPECTIVE: This study shows changes in ASIC mRNA expression and behavioral hyperalgesia of C57Bl/6 (wild type), ASIC1-/-, and ASIC3-/- mice before and after the induction of muscle inflammation.
Gene_expression (expression) of ASIC mRNA in muscle associated with hyperalgesia, inflammation and asic
1) Confidence 0.76 Published 2010 Journal J Pain Section Abstract Doc Link 20015700 Disease Relevance 1.64 Pain Relevance 1.39
We examined the expression of ASIC1, ASIC2, and ASIC3 mRNAs in lumbar dorsal root ganglion neurons before and 24 hours after carrageenan-induced muscle inflammation.
Spec (examined) Gene_expression (expression) of ASIC1 in muscle associated with ganglion cysts, inflammation and root ganglion neuron
2) Confidence 0.76 Published 2010 Journal J Pain Section Abstract Doc Link 20015700 Disease Relevance 0.95 Pain Relevance 0.44
In particular in zebrafish, ASICs genes are expressed in the trigeminal ganglion, the posterior and anterior lateral line ganglia innervating trunk and head neuromasts, the otic sensory neurons, and some nuclei of midbrain and hindbrain involved in integration of sensory inputs 8.
Gene_expression (expressed) of ASIC in trunk associated with ganglion cysts, trigeminal ganglion, midbrain and asic
3) Confidence 0.75 Published 2006 Journal International Journal of Biological Sciences Section Body Doc Link PMC1458428 Disease Relevance 0.10 Pain Relevance 0.44
The ASICs gene subfamily is expressed in CNS and PNS, and has a conserved role in the processing of sensory information in vertebrates 8, 35.
Gene_expression (expressed) of ASIC associated with peripheral nervous system and asic
4) Confidence 0.75 Published 2006 Journal International Journal of Biological Sciences Section Body Doc Link PMC1458428 Disease Relevance 0.09 Pain Relevance 0.44
ASIC1a and ASIC3, which are expressed in nociceptive neurons, have been implicated in inflammation and knockout mice studies support the role of ASIC3 in various pain processes.
Gene_expression (expressed) of ASIC1a in neurons associated with targeted disruption, nociception, pain and inflammation
5) Confidence 0.73 Published 2007 Journal Toxicon Section Abstract Doc Link 17113616 Disease Relevance 0.54 Pain Relevance 0.47
RESULTS: ASIC1 was the dominant ASIC subunit expressed in bladder epithelium, whereas both ASIC1 and ASIC2 were expressed in bladder smooth muscle.
Gene_expression (expressed) of ASIC1 in epithelium
6) Confidence 0.69 Published 2009 Journal BJU Int. Section Body Doc Link 19493263 Disease Relevance 0.15 Pain Relevance 0
In the mucosa, the ASIC1 gene was more highly expressed in male than in female mice, whereas the expression level of ASIC2 in the bladder muscle was higher in female than in male mice.
Gene_expression (expressed) of ASIC1 gene in bladder
7) Confidence 0.69 Published 2009 Journal BJU Int. Section Body Doc Link 19493263 Disease Relevance 0.14 Pain Relevance 0
RESULTS: ASIC1 was the dominant ASIC subunit expressed in bladder epithelium, whereas both ASIC1 and ASIC2 were expressed in bladder smooth muscle.
Gene_expression (expressed) of ASIC1 in epithelium
8) Confidence 0.69 Published 2009 Journal BJU Int. Section Body Doc Link 19493263 Disease Relevance 0.16 Pain Relevance 0
CONCLUSIONS: We conclude that ASIC2a and -3 are the major ASIC subunits in cardiac dorsal root ganglia neurons and provide potential molecular targets to attenuate chest pain and deleterious reflexes associated with cardiac disease.


Gene_expression (subunits) of ASIC2a in dorsal root ganglia
9) Confidence 0.64 Published 2009 Journal Circ. Res. Section Body Doc Link 19590043 Disease Relevance 0.06 Pain Relevance 0
RESULTS: ASIC1 was the dominant ASIC subunit expressed in bladder epithelium, whereas both ASIC1 and ASIC2 were expressed in bladder smooth muscle.
Gene_expression (expressed) of ASIC1 in epithelium
10) Confidence 0.60 Published 2009 Journal BJU Int. Section Body Doc Link 19493263 Disease Relevance 0.16 Pain Relevance 0
We determined relative expression of ASIC1, 2, and 3 in mouse thoracolumbar dorsal root ganglia (DRG) by quantitative reverse-transcriptase polymerase chain reaction (RT-PCR) analysis (QPCR) and specifically in retrogradely traced colonic neurons isolated via laser capture microdissection.
Spec (determined) Gene_expression (expression) of ASIC1 in neurons
11) Confidence 0.57 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17177258 Disease Relevance 0 Pain Relevance 0.36
CONCLUSIONS: We conclude that ASIC2a and -3 are the major ASIC subunits in cardiac dorsal root ganglia neurons and provide potential molecular targets to attenuate chest pain and deleterious reflexes associated with cardiac disease.


Gene_expression (subunits) of ASIC in dorsal root ganglia
12) Confidence 0.56 Published 2009 Journal Circ. Res. Section Body Doc Link 19590043 Disease Relevance 0.06 Pain Relevance 0
Finally, bafilomycin A1, an inhibitor of the vacuolar H+-ATPase, reversed the hyperalgesia and down-regulated ASIC1a mRNA expression in the DRGs.
Gene_expression (expression) of ASIC1a in DRGs associated with ganglion cysts and hyperalgesia
13) Confidence 0.55 Published 2006 Journal Bone Section Abstract Doc Link 16769263 Disease Relevance 0.96 Pain Relevance 0.75
Of note, ZOL decreased the ASIC1a mRNA expression and c-Fos.
Gene_expression (expression) of ASIC1a
14) Confidence 0.55 Published 2006 Journal Bone Section Abstract Doc Link 16769263 Disease Relevance 1.46 Pain Relevance 0.95
ASIC1a and ASIC1b are alternative splice products of the ASIC1 gene.
Gene_expression (products) of ASIC1a
15) Confidence 0.54 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12198124 Disease Relevance 0.10 Pain Relevance 0.10
ASIC1a and ASIC1b are alternative splice products of the ASIC1 gene.
Gene_expression (products) of ASIC1
16) Confidence 0.54 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12198124 Disease Relevance 0.10 Pain Relevance 0.10
We conclude that ASIC1, 2, and 3 are expressed preferentially in colonic neurons within thoracolumbar DRG.
Gene_expression (expressed) of ASIC1 in DRG
17) Confidence 0.50 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17177258 Disease Relevance 0 Pain Relevance 0.34
In contrast to whole DRG, FISH of colonic neurons showed ASIC3 expression in 73 +/- 2%, ASIC2 in 47 +/- 0.5%, and ASIC1 in 30 +/- 2%.
Gene_expression (expression) of ASIC1 in DRG
18) Confidence 0.50 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17177258 Disease Relevance 0 Pain Relevance 0.41
Treatment of the DRG cell line F-11 with acid (pH5.5) increased ASIC1a, 1b and 3 mRNA expression and nuclear c-Fos expression.
Gene_expression (expression) of ASIC1a
19) Confidence 0.50 Published 2006 Journal Bone Section Abstract Doc Link 16769263 Disease Relevance 1.43 Pain Relevance 0.97
We contrasted the physiology and peripheral targets of subclassified nociceptive and nonnociceptive afferents that express acid-sensing ion channel (ASIC)-like currents.
Gene_expression (express) of acid-sensing ion channel associated with nociception and asic
20) Confidence 0.41 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16407431 Disease Relevance 0.15 Pain Relevance 0.30

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