INT93192

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Context Info
Confidence 0.52
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 4.63
Pain Relevance 4.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn2) plasma membrane (Accn2)
Anatomy Link Frequency
sensory neurons 1
muscle 1
DRGs 1
Accn2 (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 23 99.60 Very High Very High Very High
Inflammation 26 99.28 Very High Very High Very High
Root ganglion neuron 5 98.32 Very High Very High Very High
spinal dorsal horn 2 97.88 Very High Very High Very High
ASIC 21 96.84 Very High Very High Very High
c fibre 68 96.32 Very High Very High Very High
Visceral pain 2 93.60 High High
IPN 3 92.80 High High
TRP channel 30 90.48 High High
action potential duration 4 88.16 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 271 99.68 Very High Very High Very High
Hyperalgesia 27 99.60 Very High Very High Very High
INFLAMMATION 20 99.28 Very High Very High Very High
Status Epilepticus 3 98.28 Very High Very High Very High
Acidosis 7 97.68 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 93.60 High High
Inflammatory Pain 3 92.80 High High
Death 29 91.92 High High
Hypercalcemia 6 89.08 High High
Osteoporosis 6 88.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined the expression of ASIC1, ASIC2, and ASIC3 mRNAs in lumbar dorsal root ganglion neurons before and 24 hours after carrageenan-induced muscle inflammation.
Spec (examined) Transcription (expression) of ASIC1 in muscle associated with ganglion cysts, inflammation and root ganglion neuron
1) Confidence 0.52 Published 2010 Journal J Pain Section Abstract Doc Link 20015700 Disease Relevance 0.95 Pain Relevance 0.44
Localization and comparative analysis of acid-sensing ion channel (ASIC1, 2, and 3) mRNA expression in mouse colonic sensory neurons within thoracolumbar dorsal root ganglia.
Transcription (expression) of ASIC1 in sensory neurons
2) Confidence 0.44 Published 2007 Journal J. Comp. Neurol. Section Title Doc Link 17177258 Disease Relevance 0 Pain Relevance 0.35
Of note, ZOL decreased the ASIC1a mRNA expression and c-Fos.
Transcription (expression) of ASIC1a
3) Confidence 0.44 Published 2006 Journal Bone Section Abstract Doc Link 16769263 Disease Relevance 1.46 Pain Relevance 0.95
Finally, bafilomycin A1, an inhibitor of the vacuolar H+-ATPase, reversed the hyperalgesia and down-regulated ASIC1a mRNA expression in the DRGs.
Transcription (expression) of ASIC1a in DRGs associated with ganglion cysts and hyperalgesia
4) Confidence 0.44 Published 2006 Journal Bone Section Abstract Doc Link 16769263 Disease Relevance 0.96 Pain Relevance 0.75
Analysis of the expression of putative mechanosensitive ion channels by RT-PCR shows increased mRNA levels for acid-sensitive ion channel 2a (ASIC2a) and ASIC2b but not for ASIC1 and ASIC3 in GDNF-overexpressing animals.
Transcription (levels) of ASIC2b
5) Confidence 0.24 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.15 Pain Relevance 0.59
Analysis of the expression of putative mechanosensitive ion channels by RT-PCR shows increased mRNA levels for acid-sensitive ion channel 2a (ASIC2a) and ASIC2b but not for ASIC1 and ASIC3 in GDNF-overexpressing animals.
Transcription (levels) of ASIC1
6) Confidence 0.24 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.15 Pain Relevance 0.60
The mRNA levels for the putative mechanosensitive ion channels ASIC2a and 2b are increased, whereas transcript levels for the heat receptor TRPV1 are decreased.
Transcription (levels) of ASIC2a
7) Confidence 0.24 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.28
Analysis of the expression of putative mechanosensitive ion channels by RT-PCR shows increased mRNA levels for acid-sensitive ion channel 2a (ASIC2a) and ASIC2b but not for ASIC1 and ASIC3 in GDNF-overexpressing animals.
Transcription (levels) of ASIC2a
8) Confidence 0.21 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.15 Pain Relevance 0.59
In animals treated with pilocarpine (380 mg/kg) to induce SE, we observed a marked decrease of ASIC2b mRNA levels in all hippocampal areas and of ASIC1a mRNA levels in the CA1-2 fields.
Transcription (levels) of ASIC1a associated with status epilepticus
9) Confidence 0.07 Published 2001 Journal Neurobiol. Dis. Section Abstract Doc Link 11162239 Disease Relevance 0.71 Pain Relevance 0.24

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