INT93193

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Context Info
Confidence 0.69
First Reported 2001
Last Reported 2010
Negated 5
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 7.20
Pain Relevance 6.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn2) plasma membrane (Accn2)
Anatomy Link Frequency
neuronal 2
Muscle 2
central nervous system 1
Accn2 (Mus musculus)
Pain Link Frequency Relevance Heat
ASIC 57 100.00 Very High Very High Very High
Endep 6 100.00 Very High Very High Very High
Central nervous system 1 99.68 Very High Very High Very High
Inflammation 47 99.64 Very High Very High Very High
antagonist 6 98.76 Very High Very High Very High
Pain 25 98.60 Very High Very High Very High
ischemia 8 98.16 Very High Very High Very High
Glutamate 24 97.84 Very High Very High Very High
analgesia 1 97.40 Very High Very High Very High
tricyclic antidepressant 1 96.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acidosis 23 99.92 Very High Very High Very High
Injury 12 99.82 Very High Very High Very High
INFLAMMATION 49 99.64 Very High Very High Very High
Anxiety Disorder 2 98.68 Very High Very High Very High
Targeted Disruption 53 98.64 Very High Very High Very High
Pain 23 98.60 Very High Very High Very High
Cv General 4 Under Development 2 98.52 Very High Very High Very High
Death 26 97.12 Very High Very High Very High
Ganglion Cysts 203 95.48 Very High Very High Very High
Hyperalgesia 36 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, activation of ASIC1a during prolonged acidosis following cerebral ischemia induces neuronal death.
Positive_regulation (activation) of ASIC1a in neuronal associated with acidosis, cv general 4 under development, ischemia and death
1) Confidence 0.69 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 17984098 Disease Relevance 0.57 Pain Relevance 0.24
During conditions that normally induced steady-state desensitization, these peptides profoundly enhanced ASIC1a activity.
Positive_regulation (enhanced) of ASIC1a
2) Confidence 0.69 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 17984098 Disease Relevance 0.49 Pain Relevance 0.23
Muscle inflammation causes bilateral increases of ASIC2 and ASIC3 but not ASIC1 (neither ASIC1a nor ASIC1b) mRNA, suggesting differential regulation of ASIC1 versus ASIC2 and ASIC3 mRNA.
Neg (not) Positive_regulation (increases) of ASIC1a in Muscle associated with inflammation
3) Confidence 0.68 Published 2010 Journal J Pain Section Abstract Doc Link 20015700 Disease Relevance 1.25 Pain Relevance 0.64
Homomeric acid-sensing ion channel 1 (ASIC1) can be activated by extracellular H(+) in the physiological pH range and may, therefore, contribute to neurotransmission and peripheral pain perception.
Positive_regulation (activated) of ASIC1 associated with pain
4) Confidence 0.56 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12198124 Disease Relevance 0.10 Pain Relevance 0.10
Similar mRNA increases were observed after inflammation in knockout mice: ASIC2 mRNA increases in ASIC3-/- mice; ASIC2 and ASIC3 mRNAs increase in ASIC1-/- mice.
Positive_regulation (increase) of ASIC1 associated with targeted disruption and inflammation
5) Confidence 0.49 Published 2010 Journal J Pain Section Abstract Doc Link 20015700 Disease Relevance 1.46 Pain Relevance 0.85
Furthermore, a drop in pH induced calcium influx by activating homomeric ASIC1a channels.
Positive_regulation (activating) of ASIC1a
6) Confidence 0.46 Published 2009 Journal Neuroscience Section Abstract Doc Link 19376200 Disease Relevance 0.07 Pain Relevance 0.42
Muscle inflammation causes bilateral increases of ASIC2 and ASIC3 but not ASIC1 (neither ASIC1a nor ASIC1b) mRNA, suggesting differential regulation of ASIC1 versus ASIC2 and ASIC3 mRNA.
Neg (not) Positive_regulation (increases) of ASIC1 in Muscle associated with inflammation
7) Confidence 0.46 Published 2010 Journal J Pain Section Abstract Doc Link 20015700 Disease Relevance 1.24 Pain Relevance 0.64
BLINaC is only 30% identical to ASICs and it is not activated by an extracellular acidification, although it is able to form an amiloride-sensitive Na+-selective channel.
Neg (not) Positive_regulation (activated) of ASIC associated with asic
8) Confidence 0.45 Published 2006 Journal International Journal of Biological Sciences Section Body Doc Link PMC1458428 Disease Relevance 0.09 Pain Relevance 0.28
Moreover, we show that extracellular, divalent cations like Ca(2+) and Mg(2+) as well as the polyvalent cation spermine shift the steady-state inactivation of ASIC1a and ASIC1b to more acidic values.
Positive_regulation (inactivation) of ASIC1a
9) Confidence 0.40 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12198124 Disease Relevance 0.15 Pain Relevance 0.11
The mRNA levels for the putative mechanosensitive ion channels ASIC2a and 2b are increased, whereas transcript levels for the heat receptor TRPV1 are decreased.
Positive_regulation (increased) of ASIC2a
10) Confidence 0.31 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.28
Interestingly, spermine shifts the steady-state desensitization of ASIC1a channels to more acidic pH conditions [29] and contributes significantly to ischemic neuronal injury through enhancing ASIC1a activity [30].
Positive_regulation (enhancing) of ASIC1a in neuronal associated with injury
11) Confidence 0.24 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.74 Pain Relevance 0.33
Analysis of the expression of putative mechanosensitive ion channels by RT-PCR shows increased mRNA levels for acid-sensitive ion channel 2a (ASIC2a) and ASIC2b but not for ASIC1 and ASIC3 in GDNF-overexpressing animals.
Neg (not) Positive_regulation (increased) of ASIC2b
12) Confidence 0.21 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.15 Pain Relevance 0.65
ASIC1a activation by amitriptyline and FMRF-amide is removed by serine proteases.
Positive_regulation (activation) of ASIC1a associated with endep
13) Confidence 0.21 Published 2008 Journal Channels (Austin) Section Title Doc Link 18927513 Disease Relevance 0 Pain Relevance 0.36
Analysis of the expression of putative mechanosensitive ion channels by RT-PCR shows increased mRNA levels for acid-sensitive ion channel 2a (ASIC2a) and ASIC2b but not for ASIC1 and ASIC3 in GDNF-overexpressing animals.
Neg (not) Positive_regulation (increased) of ASIC2a
14) Confidence 0.18 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.15 Pain Relevance 0.64
TBOA led to an increase in the amplitude of the aSIC by 112.1 ± 31.7 pA (Fig. 3, B and C).
Positive_regulation (increase) of aSIC associated with asic
15) Confidence 0.08 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888059 Disease Relevance 0.06 Pain Relevance 0.40
ASIC1a, ASIC2a, and ASIC2b are also distributed in the central nervous system where their function remains unclear.
Positive_regulation (distributed) of ASIC1a in central nervous system associated with central nervous system
16) Confidence 0.06 Published 2001 Journal Neurobiol. Dis. Section Abstract Doc Link 11162239 Disease Relevance 0.67 Pain Relevance 0.24

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