INT93194

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Context Info
Confidence 0.35
First Reported 2001
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.69
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn2) plasma membrane (Accn2)
Anatomy Link Frequency
DRGs 2
Accn2 (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 6 99.90 Very High Very High Very High
IPN 1 92.80 High High
TRP channel 1 91.08 High High
Central nervous system 1 89.04 High High
ASIC 4 86.40 High High
Pain 7 84.56 Quite High
sodium channel 1 80.36 Quite High
Hippocampus 1 76.80 Quite High
spinal dorsal horn 1 76.12 Quite High
Inflammation 5 75.00 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 6 99.90 Very High Very High Very High
Ganglion Cysts 3 99.68 Very High Very High Very High
Status Epilepticus 3 99.54 Very High Very High Very High
Acidosis 4 96.60 Very High Very High Very High
Inflammatory Pain 1 92.80 High High
Death 1 91.92 High High
Pain 6 84.56 Quite High
INFLAMMATION 2 75.00 Quite High
Epilepsy 1 75.00 Quite High
Hypercalcemia 3 67.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, bafilomycin A1, an inhibitor of the vacuolar H+-ATPase, reversed the hyperalgesia and down-regulated ASIC1a mRNA expression in the DRGs.
Negative_regulation (down-regulated) of Transcription (expression) of ASIC1a in DRGs associated with ganglion cysts and hyperalgesia
1) Confidence 0.35 Published 2006 Journal Bone Section Abstract Doc Link 16769263 Disease Relevance 0.97 Pain Relevance 0.76
In animals treated with pilocarpine (380 mg/kg) to induce SE, we observed a marked decrease of ASIC2b mRNA levels in all hippocampal areas and of ASIC1a mRNA levels in the CA1-2 fields.
Negative_regulation (decrease) of Transcription (levels) of ASIC1a associated with status epilepticus
2) Confidence 0.06 Published 2001 Journal Neurobiol. Dis. Section Abstract Doc Link 11162239 Disease Relevance 0.72 Pain Relevance 0.24

General Comments

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