INT93195

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Context Info
Confidence 0.59
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 7.23
Pain Relevance 6.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn2) plasma membrane (Accn2)
Anatomy Link Frequency
neuronal 1
muscle 1
Accn2 (Mus musculus)
Pain Link Frequency Relevance Heat
ASIC 37 100.00 Very High Very High Very High
Lasting pain 3 99.44 Very High Very High Very High
Mechanosensation 12 99.04 Very High Very High Very High
Hyperalgesia 16 98.76 Very High Very High Very High
Pain 33 98.48 Very High Very High Very High
Neuropeptide 30 98.48 Very High Very High Very High
spinal dorsal horn 1 98.44 Very High Very High Very High
aPETx2 3 98.02 Very High Very High Very High
PcTx1 3 97.80 Very High Very High Very High
ischemia 10 96.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 46 99.80 Very High Very High Very High
Status Epilepticus 3 99.54 Very High Very High Very High
Pain 25 99.44 Very High Very High Very High
Hyperalgesia 18 98.76 Very High Very High Very High
Ganglion Cysts 136 98.04 Very High Very High Very High
Injury 1 97.52 Very High Very High Very High
Death 25 97.28 Very High Very High Very High
Acidosis 10 96.60 Very High Very High Very High
Cv General 4 Under Development 5 96.36 Very High Very High Very High
INFLAMMATION 10 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endogenous arginine-phenylalanine-amide-related peptides alter steady-state desensitization of ASIC1a.
Negative_regulation (desensitization) of ASIC1a associated with neuropeptide
1) Confidence 0.59 Published 2008 Journal J. Biol. Chem. Section Title Doc Link 17984098 Disease Relevance 0.53 Pain Relevance 0.55
In this study, we found exogenous and endogenous arginine-phenylalanine-amide (RF-amide)-related peptides decreased the pH sensitivity of ASIC1a steady-state desensitization.
Negative_regulation (desensitization) of ASIC1a
2) Confidence 0.43 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 17984098 Disease Relevance 0.52 Pain Relevance 0.23
Surprisingly, steady-state desensitization of human ASIC1a was also affected by a greater number of peptides compared with mouse ASIC1a.
Negative_regulation (desensitization) of ASIC1a
3) Confidence 0.43 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 17984098 Disease Relevance 0.44 Pain Relevance 0.22
ASICs undergo steady-state desensitization, a characteristic that limits ASIC1a activity and may play a prominent role in the prevention of ASIC1a-evoked neuronal death.
Negative_regulation (limits) of ASIC1a in neuronal associated with death and asic
4) Confidence 0.43 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 17984098 Disease Relevance 0.57 Pain Relevance 0.23
Overall, these experiments lend vital insight into steady-state desensitization of ASIC1a and expand our understanding of the structural determinants of RF-amide-related peptide modulation.
Negative_regulation (desensitization) of ASIC1a
5) Confidence 0.43 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 17984098 Disease Relevance 0.34 Pain Relevance 0.28
-mechanonociceptors showed a decrease in responsiveness [11] and in ASIC1 null mutants cutaneous mechanosensation was unchanged from wild-type levels [12].
Negative_regulation (decrease) of ASIC1 associated with mechanosensation
6) Confidence 0.41 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074358 Disease Relevance 0 Pain Relevance 0.60
Recently, two peptides, PcTx1 and APETx2, isolated from a spider and a sea anemone, have been characterized as selective and high-affinity inhibitors for ASIC1a and ASIC3 channels, respectively.
Negative_regulation (inhibitors) of ASIC1a associated with pctx1 and apetx2
7) Confidence 0.40 Published 2007 Journal Toxicon Section Abstract Doc Link 17113616 Disease Relevance 0.49 Pain Relevance 0.83
Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1.
Neg (not) Negative_regulation (loss) of ASIC1 in muscle associated with hyperalgesia
8) Confidence 0.37 Published 2003 Journal Pain Section Title Doc Link 14659506 Disease Relevance 0.91 Pain Relevance 1.00
Of note, ZOL decreased the ASIC1a mRNA expression and c-Fos.
Negative_regulation (decreased) of ASIC1a
9) Confidence 0.35 Published 2006 Journal Bone Section Abstract Doc Link 16769263 Disease Relevance 1.47 Pain Relevance 0.96
Moreover, we show that extracellular, divalent cations like Ca(2+) and Mg(2+) as well as the polyvalent cation spermine shift the steady-state inactivation of ASIC1a and ASIC1b to more acidic values.
Negative_regulation (inactivation) of ASIC1a
10) Confidence 0.35 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12198124 Disease Relevance 0.15 Pain Relevance 0.11
Transcript levels for ASIC1, 2a, 2b and 3 are decreased in female transgenic mice and ASIC2a is decreased in males.
Negative_regulation (decreased) of ASIC2a associated with targeted disruption
11) Confidence 0.23 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.49 Pain Relevance 0.19
Transcript levels for ASIC1, 2a, 2b and 3 are decreased in female transgenic mice and ASIC2a is decreased in males.
Negative_regulation (decreased) of ASIC1 associated with targeted disruption
12) Confidence 0.19 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.50 Pain Relevance 0.13
In animals treated with pilocarpine (380 mg/kg) to induce SE, we observed a marked decrease of ASIC2b mRNA levels in all hippocampal areas and of ASIC1a mRNA levels in the CA1-2 fields.
Negative_regulation (decrease) of ASIC1a associated with status epilepticus
13) Confidence 0.08 Published 2001 Journal Neurobiol. Dis. Section Abstract Doc Link 11162239 Disease Relevance 0.72 Pain Relevance 0.24
The aSIC was blocked by TTX (1 µM) but not by CNQX (50 µM; not depicted).
Negative_regulation (blocked) of aSIC associated with asic
14) Confidence 0.05 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888059 Disease Relevance 0 Pain Relevance 0.45
However, when CNQX was added to the aCSF the decay time of the aSIC under TBOA (200 µM) was reduced to 10.3 ± 6.1 s.


Negative_regulation (reduced) of aSIC associated with asic
15) Confidence 0.05 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888059 Disease Relevance 0.08 Pain Relevance 0.28

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