INT93196

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 2.97
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ASIC1) transport (ASIC1) plasma membrane (ASIC1)
Anatomy Link Frequency
neurons 1
ASIC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ASIC 46 100.00 Very High Very High Very High
Inflammation 2 99.44 Very High Very High Very High
Neuropeptide 4 98.28 Very High Very High Very High
PcTx1 2 98.04 Very High Very High Very High
Potency 2 97.16 Very High Very High Very High
Central nervous system 3 89.04 High High
Pain 6 87.92 High High
imagery 8 85.52 High High
ischemia 5 83.24 Quite High
sodium channel 1 80.36 Quite High
Disease Link Frequency Relevance Heat
Status Epilepticus 3 99.54 Very High Very High Very High
INFLAMMATION 2 99.44 Very High Very High Very High
Injury 2 98.16 Very High Very High Very High
Toxicity 12 97.00 Very High Very High Very High
Acidosis 16 96.60 Very High Very High Very High
Glioma 5 91.24 High High
Pain 6 87.92 High High
Death 17 86.88 High High
Cv Unclassified Under Development 4 83.24 Quite High
Brain Hemorrhage 1 81.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This toxin is thought to be a specific peptide inhibitor of acid-sensing ion channel (ASIC1), a member of the Deg/ENaC superfamily of cation channels.
Negative_regulation (inhibitor) of ASIC1
1) Confidence 0.43 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 17615161 Disease Relevance 0.48 Pain Relevance 0.10
Prior pharmacologic and genetic studies have shown that ASIC1a channel inactivation markedly diminishes CNS susceptibility to ischemic damage.
Negative_regulation (inactivation) of ASIC1a
2) Confidence 0.42 Published 2008 Journal Glia Section Abstract Doc Link 18452213 Disease Relevance 0.09 Pain Relevance 0.30
Diminazene blocked ASIC1a, -1b -2a, and -3 currents expressed in CHO cells with a rank order of potency 1b > 3 > 2a >or= 1a.
Negative_regulation (blocked) of ASIC1a associated with potency
3) Confidence 0.41 Published 2010 Journal Neuropharmacology Section Abstract Doc Link 20114056 Disease Relevance 0.29 Pain Relevance 0.47
Furthermore, inhibition of ASICs, especially ASIC1a, protected hippocampal neurons from acidotic injuries.
Negative_regulation (inhibition) of ASIC1a in neurons associated with injury and asic
4) Confidence 0.41 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20478356 Disease Relevance 0.74 Pain Relevance 0.44
As an ion channel, the number of ASIC1a at cell surface will determine the magnitude of ASIC1a-mediated response.
Negative_regulation (number) of ASIC1a
5) Confidence 0.31 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.19 Pain Relevance 0
To obtain a quantitative measurement of PICK1's effect on surface ASIC1a, we normalized surface ASIC1a to total ASIC1a and obtained the ratio of ASIC1a at cell surface.
Negative_regulation (measurement) of ASIC1a
6) Confidence 0.31 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.13 Pain Relevance 0
Moreover, we show that RFamide neuropeptides, putative modulators of ASIC activity during inflammation, drastically slow down the desensitization of the ASIC1b/3 heteromer with an apparent dissociation constant of approximately 24microM.
Negative_regulation (desensitization) of ASIC1b associated with inflammation, neuropeptide and asic
7) Confidence 0.29 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16549075 Disease Relevance 0.32 Pain Relevance 0.45
In animals treated with pilocarpine (380 mg/kg) to induce SE, we observed a marked decrease of ASIC2b mRNA levels in all hippocampal areas and of ASIC1a mRNA levels in the CA1-2 fields.
Negative_regulation (decrease) of ASIC2b associated with status epilepticus
8) Confidence 0.00 Published 2001 Journal Neurobiol. Dis. Section Abstract Doc Link 11162239 Disease Relevance 0.72 Pain Relevance 0.24

General Comments

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