INT93197

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Context Info
Confidence 0.61
First Reported 2001
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 1.94
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ASIC2)
Anatomy Link Frequency
somatic muscle 1
central nervous system 1
neural 1
hippocampus 1
ASIC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 13 100.00 Very High Very High Very High
sodium channel 5 100.00 Very High Very High Very High
Central nervous system 1 99.68 Very High Very High Very High
potassium channel 4 99.58 Very High Very High Very High
Hippocampus 11 99.32 Very High Very High Very High
Kinase C 15 98.80 Very High Very High Very High
ASIC 12 98.40 Very High Very High Very High
Pain 7 98.28 Very High Very High Very High
Calcium channel 3 93.16 High High
tissue acidosis 2 92.44 High High
Disease Link Frequency Relevance Heat
Acidosis 4 99.60 Very High Very High Very High
Convulsion 5 98.72 Very High Very High Very High
Pain 6 98.28 Very High Very High Very High
Epilepsy 5 96.96 Very High Very High Very High
Status Epilepticus 3 89.44 High High
Obesity 19 75.00 Quite High
Death 1 61.12 Quite High
Disease 1 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was hypothesized that depolarization of the sarcolemma resulting from activation of cholinomimetic-sensitive channel-receptor complex of the Lumbricus terrestris somatic muscle cells is primarily determined by sodium permeability of the membrane.
Positive_regulation (activation) of cholinomimetic-sensitive channel-receptor in somatic muscle
1) Confidence 0.61 Published 2002 Journal Bull. Exp. Biol. Med. Section Abstract Doc Link 12802441 Disease Relevance 0 Pain Relevance 0.09
This paper shows that Zn(2+) potentiates the acid activation of homomeric and heteromeric ASIC2a-containing channels (i.e.
Positive_regulation (activation) of ASIC2a
2) Confidence 0.29 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11457851 Disease Relevance 0.18 Pain Relevance 0.27
This paper shows that Zn(2+) potentiates the acid activation of homomeric and heteromeric ASIC2a-containing channels (i.e.
Positive_regulation (activation) of ASIC2a
3) Confidence 0.29 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11457851 Disease Relevance 0.18 Pain Relevance 0.27
The OAG-induced increase in ASIC2a current amplitude did not involve any change in the unitary conductance of the ASIC2a channel, whether co-expressed with PICK1 or not.
Spec (whether) Positive_regulation (conductance) of ASIC2a
4) Confidence 0.19 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12399460 Disease Relevance 0.06 Pain Relevance 0.35
The OAG-induced increase in ASIC2a current amplitude did not involve any change in the unitary conductance of the ASIC2a channel, whether co-expressed with PICK1 or not.
Spec (whether) Positive_regulation (increase) of ASIC2a
5) Confidence 0.16 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12399460 Disease Relevance 0.06 Pain Relevance 0.36
We now show that the amplitude of the ASIC2a current, which was only modestly increased ( approximately +30%) by the PKC activator 1-oleyl-2-acetyl-sn-glycerol (OAG, 50 microm) in the absence of PICK1, was strongly potentiated ( approximately +300%) in the presence of PICK1.
Positive_regulation (increased) of ASIC2a associated with kinase c
6) Confidence 0.16 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12399460 Disease Relevance 0.09 Pain Relevance 0.40
ASIC1a, ASIC2a, and ASIC2b are also distributed in the central nervous system where their function remains unclear.
Positive_regulation (distributed) of ASIC2a in central nervous system associated with central nervous system
7) Confidence 0.06 Published 2001 Journal Neurobiol. Dis. Section Abstract Doc Link 11162239 Disease Relevance 0.67 Pain Relevance 0.24
In addition, we demonstrated that Kv4.3 and Eag1, potassium channel genes, and NE-Na, a TTX-sensitive sodium channel gene, were highly induced following neural differentiation.


Positive_regulation (induced) of TTX-sensitive sodium channel gene in neural associated with tetrodotoxin, sodium channel and potassium channel
8) Confidence 0.06 Published 2010 Journal BMC Cell Biol Section Abstract Doc Link PMC2867791 Disease Relevance 0.07 Pain Relevance 0.41
Up-regulated astroglial TWIK-related acid-sensitive K+ channel-1 (TASK-1) in the hippocampus of seizure-sensitive gerbils: a target of anti-epileptic drugs.
Positive_regulation (Up-regulated) of channel-1 in hippocampus associated with epilepsy, convulsion and hippocampus
9) Confidence 0.00 Published 2007 Journal Brain Res. Section Title Doc Link 17959156 Disease Relevance 0.61 Pain Relevance 0.40

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