INT93200

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 3.27
Pain Relevance 3.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ASIC2)
Anatomy Link Frequency
neurons 2
bone marrow 1
central nervous system 1
ASIC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
ASIC 30 100.00 Very High Very High Very High
tetrodotoxin 24 100.00 Very High Very High Very High
sodium channel 9 100.00 Very High Very High Very High
Central nervous system 39 99.68 Very High Very High Very High
potassium channel 4 99.60 Very High Very High Very High
dorsal root ganglion 18 99.20 Very High Very High Very High
Pain 188 98.28 Very High Very High Very High
Calcium channel 11 96.76 Very High Very High Very High
nociceptor 12 88.44 High High
Root ganglion neuron 1 86.12 High High
Disease Link Frequency Relevance Heat
Acidosis 4 99.60 Very High Very High Very High
Ganglion Cysts 19 98.72 Very High Very High Very High
Pain 245 98.28 Very High Very High Very High
Status Epilepticus 3 89.44 High High
Hypoxia 2 86.48 High High
INFLAMMATION 82 85.72 High High
Hypercalcemia 2 85.16 High High
Osteoporosis 2 84.52 Quite High
Frailty 96 82.00 Quite High
Nervous System Injury 26 79.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Modulators of the cGMP/PKG pathway had no effect on the potentiation, but in excised patches from CHO cells expressing ASIC2a, the potentiation could be reversed by externally applied reducing agents.
Gene_expression (expressing) of ASIC2a
1) Confidence 0.60 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18045919 Disease Relevance 0.55 Pain Relevance 0.71
Immunohistochemical analyses also revealed that ASIC2b, as well as ASIC2a, was expressed in a subpopulation of taste cells, and some of the cells displayed both ASIC2a and ASIC2b immunoreactivities.
Gene_expression (expressed) of ASIC2a
2) Confidence 0.38 Published 2004 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 15484827 Disease Relevance 0.06 Pain Relevance 0.03
The OAG-induced increase in ASIC2a current amplitude did not involve any change in the unitary conductance of the ASIC2a channel, whether co-expressed with PICK1 or not.
Neg (not) Spec (whether) Gene_expression (co-expressed) of ASIC2a
3) Confidence 0.23 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12399460 Disease Relevance 0.06 Pain Relevance 0.35
ASIC1a, ASIC2a, and ASIC2b are also distributed in the central nervous system where their function remains unclear.
Gene_expression (distributed) of ASIC2a in central nervous system associated with central nervous system
4) Confidence 0.09 Published 2001 Journal Neurobiol. Dis. Section Abstract Doc Link 11162239 Disease Relevance 0.67 Pain Relevance 0.24
Undifferentiated bone marrow-derived hMSCs are known to express the TTX-sensitive sodium channel gene (NE-Na), potassium channel genes (MaxiK, Kv1.4, Kv4.2, Kv4.3, and Eag1) and the calcium channel gene (CACNA1C) [56,57].
Gene_expression (express) of TTX-sensitive sodium channel gene in bone marrow associated with tetrodotoxin, calcium channel, sodium channel and potassium channel
5) Confidence 0.08 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0 Pain Relevance 0.57
Several subunits have been identified, with ASIC 1a 1b, ASIC 2a, 2b and ASIC3 expressed in the majority of dorsal root ganglion (DRG) neurons.
Gene_expression (expressed) of ASIC in neurons associated with ganglion cysts, dorsal root ganglion and asic
6) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 0.97 Pain Relevance 0.90
Several subunits have been identified, with ASIC 1a 1b, ASIC 2a, 2b and ASIC3 expressed in the majority of dorsal root ganglion (DRG) neurons.
Gene_expression (expressed) of ASIC in neurons associated with ganglion cysts, dorsal root ganglion and asic
7) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 0.96 Pain Relevance 0.90

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox