INT9321

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Context Info
Confidence 0.69
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 25
Total Number 26
Disease Relevance 10.20
Pain Relevance 6.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Anatomy Link Frequency
lumbar region 3
spinal cord 2
spinal 2
hepatocytes 1
liver 1
Igf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 416 100.00 Very High Very High Very High
Calcitonin gene-related peptide 10 100.00 Very High Very High Very High
Spinal cord 21 99.84 Very High Very High Very High
lumbar region 3 99.68 Very High Very High Very High
Inflammation 32 99.48 Very High Very High Very High
dexamethasone 45 99.16 Very High Very High Very High
Paracetamol 14 97.80 Very High Very High Very High
Somatostatin 2 96.76 Very High Very High Very High
Pain 6 94.16 High High
antagonist 18 91.36 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 37 99.48 Very High Very High Very High
Urological Neuroanatomy 10 98.98 Very High Very High Very High
Frailty 24 98.56 Very High Very High Very High
Sepsis 298 98.28 Very High Very High Very High
Acid Base Imbalance 136 98.08 Very High Very High Very High
Uremia 4 96.68 Very High Very High Very High
Intrauterine Growth Retardation 5 95.76 Very High Very High Very High
Pain 2 94.16 High High
Cancer 12 93.36 High High
Necrosis 12 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
mRNA transcripts for insulin-like growth factor I (IGF-I) and its receptor are expressed in the lumbar region of the spinal cord.
Transcription (transcripts) of IGF-I in lumbar region associated with lumbar region and spinal cord
1) Confidence 0.69 Published 1996 Journal Brain Res. Section Abstract Doc Link 8930378 Disease Relevance 0.17 Pain Relevance 0.41
mRNA transcripts for insulin-like growth factor I (IGF-I) and its receptor are expressed in the lumbar region of the spinal cord.
Transcription (expressed) of IGF-I in lumbar region associated with lumbar region and spinal cord
2) Confidence 0.69 Published 1996 Journal Brain Res. Section Abstract Doc Link 8930378 Disease Relevance 0.18 Pain Relevance 0.42
mRNA transcripts for insulin-like growth factor I (IGF-I) and its receptor are expressed in the lumbar region of the spinal cord.
Transcription (transcripts) of insulin-like growth factor I in lumbar region associated with lumbar region and spinal cord
3) Confidence 0.69 Published 1996 Journal Brain Res. Section Abstract Doc Link 8930378 Disease Relevance 0.17 Pain Relevance 0.40
The liver was stored at -70°C for subsequent analysis for the expression of mRNA of CIS, SOCS-2, SOCS-3, IGF-I and the GHR.


Transcription (expression) of IGF-I in liver
4) Confidence 0.55 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0 Pain Relevance 0.21
Nutrition increased the expression of mRNA of both IGF-I and the GHR, while these were not affected by sepsis.
Transcription (expression) of IGF-I associated with sepsis
5) Confidence 0.55 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.48 Pain Relevance 0.09
We now demonstrate continued induction of SOCS-3 expression at 72 hours after CLP, associated with reduced hepatic expression of mRNA of IGF-I and reduced serum IGF-I concentrations.
Transcription (expression) of IGF-I
6) Confidence 0.55 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.52 Pain Relevance 0.11
We show that acetaminophen indirectly stimulates spinal 5-hydroxytryptamine (5-HT)1A receptors in the formalin test, thereby increasing transcript and protein levels of low-affinity neurotrophin receptor, insulin-like growth factor-1 (IGF-1) receptor alpha subunit, and growth hormone receptor and reducing the amount of somatostatin 3 receptor (sst3R) mRNA.
Transcription (transcript) of insulin-like growth factor-1 in spinal associated with paracetamol and somatostatin
7) Confidence 0.54 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17088403 Disease Relevance 0.09 Pain Relevance 0.92
We failed to demonstrate significant differences between septic and sham-operated animals in expression of mRNA of the GHR or IGF-I, nutritional differences appearing to be of more importance.
Transcription (expression) of IGF-I
8) Confidence 0.53 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.39 Pain Relevance 0.03
The intravenous administration of limaprost enhanced increases of spinal cord tissue levels of CGRP, IGF-I, and IGF-I mRNA at 2 h after the induction of SCI.
Transcription (levels) of IGF-I in spinal cord associated with frailty, calcitonin gene-related peptide and spinal cord
9) Confidence 0.51 Published 2010 Journal Transl Res Section Abstract Doc Link 20970752 Disease Relevance 1.23 Pain Relevance 0.54
The intravenous administration of limaprost enhanced increases of spinal cord tissue levels of CGRP, IGF-I, and IGF-I mRNA at 2 h after the induction of SCI.
Transcription (levels) of IGF-I in spinal cord associated with frailty, calcitonin gene-related peptide and spinal cord
10) Confidence 0.51 Published 2010 Journal Transl Res Section Abstract Doc Link 20970752 Disease Relevance 1.24 Pain Relevance 0.54
We investigated effects of pre- and postnatal exposure to 4-MBC in the same rat offspring at brain and reproductive organ levels. 4-MBC (7, 24, 47 mg/kg/day) was administered in chow to the parent generation before mating, during gestation and lactation, and to the offspring until adulthood. mRNA of estrogen target genes involved in control of sexual behavior and gonadal functions was measured by real-time RT-PCR in ventromedial hypothalamic nucleus (VMH) and medial preoptic area (MPO) of adult offspring. 4-MBC exposure affected mRNA levels of ER alpha, progesterone receptor (PR), preproenkephalin (PPE) and insulin-like growth factor-I (IGF-I) in a sex- and region-specific manner.
Transcription (levels) of IGF-I in reproductive organ associated with urological neuroanatomy
11) Confidence 0.51 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17188730 Disease Relevance 0.47 Pain Relevance 0
We show that acetaminophen indirectly stimulates spinal 5-hydroxytryptamine (5-HT)1A receptors in the formalin test, thereby increasing transcript and protein levels of low-affinity neurotrophin receptor, insulin-like growth factor-1 (IGF-1) receptor alpha subunit, and growth hormone receptor and reducing the amount of somatostatin 3 receptor (sst3R) mRNA.
Transcription (levels) of IGF-1 in spinal associated with paracetamol and somatostatin
12) Confidence 0.47 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17088403 Disease Relevance 0.09 Pain Relevance 0.92
We now demonstrate continued induction of SOCS-3 expression at 72 hours after CLP, associated with reduced hepatic expression of mRNA of IGF-I and reduced serum IGF-I concentrations.
Transcription (expression) of serum IGF-I
13) Confidence 0.46 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.52 Pain Relevance 0.11
Parenteral versus enteral nutrition: effect on serum cytokines and the hepatic expression of mRNA of suppressor of cytokine signaling proteins, insulin-like growth factor-1 and the growth hormone receptor in rodent sepsis

Introduction

Transcription (expression) of insulin-like growth factor-1 associated with sepsis and cytokine
14) Confidence 0.41 Published 2007 Journal Crit Care Section Title Doc Link PMC2206515 Disease Relevance 0.35 Pain Relevance 0.20
In established sepsis, nutrition and the route of administration of nutrition influences the circulating cytokine patterns and expression of mRNA of SOCS proteins, GHR and IGF-I.
Transcription (expression) of IGF-I associated with sepsis and cytokine
15) Confidence 0.41 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2206515 Disease Relevance 0.15 Pain Relevance 0.19
We therefore measured the serum concentrations of a pleiotropic cytokine (IL-6) and an anti-inflammatory (IL-10) cytokine and the expression of mRNA of SOCS proteins, of IGF-I and of the growth hormone receptor (GHR) in hepatic tissue from these animals.
Transcription (expression) of IGF-I associated with inflammation and cytokine
16) Confidence 0.41 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.26 Pain Relevance 0.27
Uterine ER mRNA and IGF-I mRNA levels were not affected by short time (24 hrs) GH treatment in ovariectomized rats, while E2 in the same regimen caused increased mRNA levels in both cases [11].
Transcription (levels) of IGF-I mRNA in Uterine
17) Confidence 0.38 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0.12 Pain Relevance 0
In this study we examined the effects of these compounds on the mRNA levels of the GH receptor/GH binding protein, IGF-I, ER?
Transcription (levels) of IGF-I
18) Confidence 0.38 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0.20 Pain Relevance 0.16
We studied the effects on mRNA levels of the growth hormone (GH) receptor, insulin-like growth factor-I (IGF-I), ER?
Transcription (levels) of IGF-I
19) Confidence 0.38 Published 2003 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC156658 Disease Relevance 0.08 Pain Relevance 0.04
IGF-I, acid-labile subunit (ALS), IGFBP-1 and -3 mRNA levels were determined by Northern blot analysis.
Transcription (levels) of IGF-I
20) Confidence 0.38 Published 2003 Journal J. Surg. Res. Section Body Doc Link 12888332 Disease Relevance 0.14 Pain Relevance 0

General Comments

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