INT93213

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.93
Pain Relevance 2.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Sp1) nucleus (Sp1) intracellular (Sp1)
DNA binding (Sp1) transcription factor binding (Sp1) cytoplasm (Sp1)
Sp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 32 99.62 Very High Very High Very High
tetrodotoxin 3 95.52 Very High Very High Very High
metalloproteinase 6 77.92 Quite High
Inflammation 1 50.00 Quite Low
aspirin 1 10.00 Low Low
Disease Link Frequency Relevance Heat
Repression 5 87.24 High High
Lung Cancer 3 80.84 Quite High
INFLAMMATION 8 76.00 Quite High
Injury 1 50.00 Quite Low
Increased Venous Pressure Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exposure to NSAIDs inhibits Sp1 and ERK phosphorylation.
Phosphorylation (phosphorylation) of Sp1
1) Confidence 0.67 Published 2005 Journal Gastroenterology Section Body Doc Link 16230075 Disease Relevance 0 Pain Relevance 0
Furthermore, okadaic acid caused an increase of the threonine phosphorylation of protein kinase Czeta (PKCzeta) and activator of transcription factor (ATF2) and a decrease of the phosphorylation of Sp1.
Phosphorylation (phosphorylation) of Sp1
2) Confidence 0.20 Published 2001 Journal FEBS Lett. Section Abstract Doc Link 11163354 Disease Relevance 0.09 Pain Relevance 0.26
Second, a MEK inhibitor PD98059 inhibits MMP-2 promoter activity and Sp1 phosphorylation.
Phosphorylation (phosphorylation) of Sp1
3) Confidence 0.17 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12087091 Disease Relevance 0.27 Pain Relevance 0.86
Third, overexpression of constitutively active MEK1 stimulates Sp1 phosphorylation and MMP-2 promoter activity and antagonizes the inhibition of NSAIDs.
Phosphorylation (phosphorylation) of Sp1 associated with cinod
4) Confidence 0.17 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12087091 Disease Relevance 0.26 Pain Relevance 0.85
NSAID treatment reduces Sp1 DNA binding activity and phosphorylation and attenuates MMP-2 expression.
Phosphorylation (phosphorylation) of Sp1 associated with cinod
5) Confidence 0.13 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12087091 Disease Relevance 0.31 Pain Relevance 0.87

General Comments

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