INT9324

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Context Info
Confidence 0.50
First Reported 1989
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 5.12
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Igf2) extracellular space (Igf2) extracellular region (Igf2)
carbohydrate metabolic process (Igf2)
Anatomy Link Frequency
liver 4
placenta 4
nerves 2
Igf2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 4 97.12 Very High Very High Very High
Bile 2 95.32 Very High Very High Very High
Snapping jaw 3 90.04 High High
diabetic neuropathy 2 88.16 High High
spastic colon 2 84.76 Quite High
Chronic pancreatitis 2 81.72 Quite High
Hyperalgesia 2 79.44 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 8 99.84 Very High Very High Very High
Chronic Hepatitis 2 99.84 Very High Very High Very High
Aging 1 98.72 Very High Very High Very High
Liver Disease 6 98.56 Very High Very High Very High
Cirrhosis 2 98.00 Very High Very High Very High
Sprains And Strains 8 97.88 Very High Very High Very High
Intrauterine Growth Retardation 8 96.80 Very High Very High Very High
Hepatocellular Cancer 6 96.52 Very High Very High Very High
Neuropathic Pain 3 92.28 High High
Temporomandibular Joint Syndrome 3 90.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The prediction that IGF-I and IGF-II gene expression are reduced in diabetic nerves was recently tested and validated.
Negative_regulation (reduced) of Gene_expression (expression) of IGF-II in nerves associated with diabetes mellitus
1) Confidence 0.50 Published 1996 Journal Exp. Neurol. Section Abstract Doc Link 8690062 Disease Relevance 1.13 Pain Relevance 0.24
These results suggest that serum IGF-II reflects a reduced production of IGF-II in the liver and that it can be an index for the residual capacity of liver function.
Negative_regulation (reduced) of Gene_expression (production) of IGF-II in liver
2) Confidence 0.50 Published 1989 Journal Dig. Dis. Sci. Section Abstract Doc Link 2537715 Disease Relevance 1.23 Pain Relevance 0.21
Decreased IGF-II expression in placenta also may contribute to decreased placental growth and, in turn, to IUGR.
Negative_regulation (Decreased) of Gene_expression (expression) of IGF-II in placenta associated with intrauterine growth retardation
3) Confidence 0.38 Published 1992 Journal Pediatr. Res. Section Abstract Doc Link 1408464 Disease Relevance 0.15 Pain Relevance 0.14
The only major difference among groups in carcass and placenta mRNA abundance was a 44% decrease in placental IGF-II expression in UA-lig pups compared with pups from dams that had had no surgery or anesthesia.
Negative_regulation (decrease) of Gene_expression (expression) of IGF-II in placenta associated with anesthesia
4) Confidence 0.38 Published 1992 Journal Pediatr. Res. Section Abstract Doc Link 1408464 Disease Relevance 0.29 Pain Relevance 0.19
The gene expression of IGF1, IGF2, IGF1R, IRS1, IGFBP3, and IGFBP5 was significantly (p < 0.05) inhibited when cells were subjected to continuous biophysical strain, as compared to control at both time points.
Negative_regulation (inhibited) of Gene_expression (expression) of IGF2 associated with sprains and strains
5) Confidence 0.36 Published 2007 Journal Ann. Anat. Section Abstract Doc Link 17695985 Disease Relevance 1.01 Pain Relevance 0.27
Serum IGF-II levels (mean +/- SE) were decreased in chronic hepatitis (538 +/- 51 ng/ml; N = 29), liver cirrhosis (427 +/- 45; 50) and PHC (260 +/- 41; 17) compared to controls (830 +/- 49; 57).
Negative_regulation (decreased) of Gene_expression (levels) of Serum IGF-II in liver associated with chronic hepatitis, cirrhosis and hepatocellular cancer
6) Confidence 0.32 Published 1989 Journal Dig. Dis. Sci. Section Abstract Doc Link 2537715 Disease Relevance 1.31 Pain Relevance 0.15

General Comments

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