INT9325

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Context Info
Confidence 0.77
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 8.74
Pain Relevance 5.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Igf1r)
Anatomy Link Frequency
TMJ 2
sciatic nerve 1
B lymphocytes 1
hindlimb 1
heart 1
Igf1r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 9 99.70 Very High Very High Very High
fluoxetine 30 99.50 Very High Very High Very High
Nerve growth factor 4 99.48 Very High Very High Very High
Sciatic nerve 2 98.88 Very High Very High Very High
Inflammatory marker 2 97.16 Very High Very High Very High
cytokine 31 96.48 Very High Very High Very High
Snapping jaw 16 94.88 High High
unmyelinated 3 90.88 High High
antidepressant 6 90.28 High High
Hyperalgesia 1 88.48 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 21 99.68 Very High Very High Very High
Diabetes Mellitus 21 99.68 Very High Very High Very High
Sprains And Strains 35 99.60 Very High Very High Very High
Cognitive Disorder 9 99.28 Very High Very High Very High
Intrauterine Growth Retardation 4 99.24 Very High Very High Very High
Cardiovascular Disease 1 98.88 Very High Very High Very High
INFLAMMATION 77 97.16 Very High Very High Very High
Temporomandibular Joint Syndrome 16 94.88 High High
Hyperalgesia 1 88.48 High High
Stress 35 87.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of IGF-1r immunopositive cells in the experimental group was also significantly lower than in the control.
Gene_expression (expression) of IGF-1r
1) Confidence 0.77 Published 2007 Journal Arch. Oral Biol. Section Abstract Doc Link 17765198 Disease Relevance 0.35 Pain Relevance 0.43
The objective of this in vitro study was to determine if continuous biophysical strain regulates the gene expression of IGF1, IGF2, IGF1 receptor (IGF1R), insulin receptor substrate (IRS1), and IGF-binding proteins (IGFBP) 3 and 5 in cells from the fibrocartilaginous disc of the temporomandibular joint (TMJ).
Gene_expression (expression) of IGF1 receptor in TMJ associated with snapping jaw and sprains and strains
2) Confidence 0.74 Published 2007 Journal Ann. Anat. Section Abstract Doc Link 17695985 Disease Relevance 0.76 Pain Relevance 0.27
The objective of this in vitro study was to determine if continuous biophysical strain regulates the gene expression of IGF1, IGF2, IGF1 receptor (IGF1R), insulin receptor substrate (IRS1), and IGF-binding proteins (IGFBP) 3 and 5 in cells from the fibrocartilaginous disc of the temporomandibular joint (TMJ).
Gene_expression (expression) of IGF1R in TMJ associated with snapping jaw and sprains and strains
3) Confidence 0.74 Published 2007 Journal Ann. Anat. Section Abstract Doc Link 17695985 Disease Relevance 0.81 Pain Relevance 0.28
The gene expression of IGF1, IGF2, IGF1R, IRS1, IGFBP3, and IGFBP5 was significantly (p < 0.05) inhibited when cells were subjected to continuous biophysical strain, as compared to control at both time points.
Gene_expression (expression) of IGF1R associated with sprains and strains
4) Confidence 0.74 Published 2007 Journal Ann. Anat. Section Abstract Doc Link 17695985 Disease Relevance 0.99 Pain Relevance 0.27
Repeated FLX increased both mRNA and IGF-1R levels in the FC.
Gene_expression (levels) of IGF-1R associated with urological neuroanatomy and fluoxetine
5) Confidence 0.71 Published 2008 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17961991 Disease Relevance 0.72 Pain Relevance 1.10
IGF-1 receptor (IGF-1R) protein expression and IGF-1 mRNA levels were assessed in rat frontal cortex (FC) and hippocampus, in FLX-treated [15 mg/kg, orally; 3 (acute) or 21 (repeated) days] male Wistar rats.
Gene_expression (expression) of IGF-1R in frontal cortex associated with urological neuroanatomy, hippocampus and fluoxetine
6) Confidence 0.71 Published 2008 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17961991 Disease Relevance 0.65 Pain Relevance 0.98
Regulation of IRS-2 signaling by IGF-1 receptor in the diabetic rat heart.
Gene_expression (signaling) of IGF-1 receptor in heart associated with diabetes mellitus
7) Confidence 0.63 Published 2010 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 20555424 Disease Relevance 0.91 Pain Relevance 0.16
Acute FLX administration decreased IGF-1 mRNA levels in the FC and hippocampus and increased IGF-1R levels in the FC.
Gene_expression (levels) of IGF-1R in hippocampus associated with urological neuroanatomy, hippocampus and fluoxetine
8) Confidence 0.61 Published 2008 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17961991 Disease Relevance 0.72 Pain Relevance 1.09
Insulin receptor and IGF-I receptor (IGF-IR) expressions in DRGs and NGF content in sciatic nerve were significantly decreased in 7-month diabetic rats (P < 0.01, 0.05, and 0.005, respectively).
Gene_expression (expressions) of IGF-I receptor in sciatic nerve associated with nerve growth factor, diabetes mellitus and sciatic nerve
9) Confidence 0.56 Published 2006 Journal Diabetes Section Abstract Doc Link 17130507 Disease Relevance 1.38 Pain Relevance 0.47
We assessed the expression of IGF, IGF binding protein (IGFBP), and IGF receptor transcripts in liver, carcass, and placenta of fetal rats with IUGR resulting from unilateral uterine artery ligation.
Gene_expression (expression) of IGF receptor in uterine artery associated with intrauterine growth retardation
10) Confidence 0.12 Published 1992 Journal Pediatr. Res. Section Abstract Doc Link 1408464 Disease Relevance 0.38 Pain Relevance 0.07
Expression of insulin receptor, IGF-1R, TrkA and C was decreased in BB/Wor rats, whereas BBZDR/Wor rats showed milder or no deficits.
Gene_expression (Expression) of IGF-1R
11) Confidence 0.11 Published 2005 Journal Diabetes Metab. Res. Rev. Section Body Doc Link 15747389 Disease Relevance 0.06 Pain Relevance 0
Furthermore, levels of IGF-receptor were significantly increased in tissues from hindlimb unloaded animals treated with IGF-I.


Gene_expression (levels) of IGF-receptor in hindlimb
12) Confidence 0.11 Published 2007 Journal BMC Physiol Section Abstract Doc Link PMC1851714 Disease Relevance 0.25 Pain Relevance 0
Thus, immune cells including T and B lymphocytes [50] and mononuclear cells [51] express IGF-1 receptor.
Gene_expression (express) of IGF-1 receptor in B lymphocytes
13) Confidence 0.07 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC333413 Disease Relevance 0.51 Pain Relevance 0.27
Specimens from 12 patients were investigated histologically and immunohistochemically to obtain the distribution of the IGFs-I and -II and the IGF1 receptor.
Gene_expression (distribution) of IGF1 receptor
14) Confidence 0.02 Published 2007 Journal Ann. Anat. Section Abstract Doc Link 17695990 Disease Relevance 0.25 Pain Relevance 0.09

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