INT9325

Context Info Confidence 0.77 First Reported 1992 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 14 Total Number 14 Disease Relevance 8.74 Pain Relevance 5.48

plasma membrane (Igf1r)

Anatomy Link Frequency TMJ 2 sciatic nerve 1 B lymphocytes 1 hindlimb 1 heart 1 Igf1r (Rattus norvegicus)

Pain Link Frequency Relevance Heat Hippocampus 9 99.70 fluoxetine 30 99.50 Nerve growth factor 4 99.48 Sciatic nerve 2 98.88 Inflammatory marker 2 97.16 cytokine 31 96.48 Snapping jaw 16 94.88 unmyelinated 3 90.88 antidepressant 6 90.28 Hyperalgesia 1 88.48

Disease Link Frequency Relevance Heat Urological Neuroanatomy 21 99.68 Diabetes Mellitus 21 99.68 Sprains And Strains 35 99.60 Cognitive Disorder 9 99.28 Intrauterine Growth Retardation 4 99.24 Cardiovascular Disease 1 98.88 INFLAMMATION 77 97.16 Temporomandibular Joint Syndrome 16 94.88 Hyperalgesia 1 88.48 Stress 35 87.88

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The expression of IGF-1r immunopositive cells in the experimental group was also significantly lower than in the control.

Gene_expression (expression) of IGF-1r

1) Confidence 0.77 Published 2007 Journal Arch. Oral Biol. Section Abstract Doc Link 17765198 Disease Relevance 0.35 Pain Relevance 0.43

The objective of this in vitro study was to determine if continuous biophysical strain regulates the gene expression of IGF1, IGF2, IGF1 receptor (IGF1R), insulin receptor substrate (IRS1), and IGF-binding proteins (IGFBP) 3 and 5 in cells from the fibrocartilaginous disc of the temporomandibular joint (TMJ).

Gene_expression (expression) of IGF1 receptor in TMJ associated with snapping jaw and sprains and strains

2) Confidence 0.74 Published 2007 Journal Ann. Anat. Section Abstract Doc Link 17695985 Disease Relevance 0.76 Pain Relevance 0.27

The objective of this in vitro study was to determine if continuous biophysical strain regulates the gene expression of IGF1, IGF2, IGF1 receptor (IGF1R), insulin receptor substrate (IRS1), and IGF-binding proteins (IGFBP) 3 and 5 in cells from the fibrocartilaginous disc of the temporomandibular joint (TMJ).

Gene_expression (expression) of IGF1R in TMJ associated with snapping jaw and sprains and strains

3) Confidence 0.74 Published 2007 Journal Ann. Anat. Section Abstract Doc Link 17695985 Disease Relevance 0.81 Pain Relevance 0.28

The gene expression of IGF1, IGF2, IGF1R, IRS1, IGFBP3, and IGFBP5 was significantly (p < 0.05) inhibited when cells were subjected to continuous biophysical strain, as compared to control at both time points.

Gene_expression (expression) of IGF1R associated with sprains and strains

4) Confidence 0.74 Published 2007 Journal Ann. Anat. Section Abstract Doc Link 17695985 Disease Relevance 0.99 Pain Relevance 0.27

Repeated FLX increased both mRNA and IGF-1R levels in the FC.

Gene_expression (levels) of IGF-1R associated with urological neuroanatomy and fluoxetine

5) Confidence 0.71 Published 2008 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17961991 Disease Relevance 0.72 Pain Relevance 1.10

IGF-1 receptor (IGF-1R) protein expression and IGF-1 mRNA levels were assessed in rat frontal cortex (FC) and hippocampus, in FLX-treated [15 mg/kg, orally; 3 (acute) or 21 (repeated) days] male Wistar rats.

Gene_expression (expression) of IGF-1R in frontal cortex associated with urological neuroanatomy, hippocampus and fluoxetine

6) Confidence 0.71 Published 2008 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17961991 Disease Relevance 0.65 Pain Relevance 0.98

Regulation of IRS-2 signaling by IGF-1 receptor in the diabetic rat heart.

Gene_expression (signaling) of IGF-1 receptor in heart associated with diabetes mellitus

7) Confidence 0.63 Published 2010 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 20555424 Disease Relevance 0.91 Pain Relevance 0.16

Acute FLX administration decreased IGF-1 mRNA levels in the FC and hippocampus and increased IGF-1R levels in the FC.

Gene_expression (levels) of IGF-1R in hippocampus associated with urological neuroanatomy, hippocampus and fluoxetine

8) Confidence 0.61 Published 2008 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17961991 Disease Relevance 0.72 Pain Relevance 1.09

Insulin receptor and IGF-I receptor (IGF-IR) expressions in DRGs and NGF content in sciatic nerve were significantly decreased in 7-month diabetic rats (P < 0.01, 0.05, and 0.005, respectively).

Gene_expression (expressions) of IGF-I receptor in sciatic nerve associated with nerve growth factor, diabetes mellitus and sciatic nerve

9) Confidence 0.56 Published 2006 Journal Diabetes Section Abstract Doc Link 17130507 Disease Relevance 1.38 Pain Relevance 0.47

We assessed the expression of IGF, IGF binding protein (IGFBP), and IGF receptor transcripts in liver, carcass, and placenta of fetal rats with IUGR resulting from unilateral uterine artery ligation.

Gene_expression (expression) of IGF receptor in uterine artery associated with intrauterine growth retardation

10) Confidence 0.12 Published 1992 Journal Pediatr. Res. Section Abstract Doc Link 1408464 Disease Relevance 0.38 Pain Relevance 0.07

Expression of insulin receptor, IGF-1R, TrkA and C was decreased in BB/Wor rats, whereas BBZDR/Wor rats showed milder or no deficits.

Gene_expression (Expression) of IGF-1R

11) Confidence 0.11 Published 2005 Journal Diabetes Metab. Res. Rev. Section Body Doc Link 15747389 Disease Relevance 0.06 Pain Relevance 0

Furthermore, levels of IGF-receptor were significantly increased in tissues from hindlimb unloaded animals treated with IGF-I.

Gene_expression (levels) of IGF-receptor in hindlimb

12) Confidence 0.11 Published 2007 Journal BMC Physiol Section Abstract Doc Link PMC1851714 Disease Relevance 0.25 Pain Relevance 0

Thus, immune cells including T and B lymphocytes [50] and mononuclear cells [51] express IGF-1 receptor.

Gene_expression (express) of IGF-1 receptor in B lymphocytes

13) Confidence 0.07 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC333413 Disease Relevance 0.51 Pain Relevance 0.27

Specimens from 12 patients were investigated histologically and immunohistochemically to obtain the distribution of the IGFs-I and -II and the IGF1 receptor.

Gene_expression (distribution) of IGF1 receptor

14) Confidence 0.02 Published 2007 Journal Ann. Anat. Section Abstract Doc Link 17695990 Disease Relevance 0.25 Pain Relevance 0.09

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