INT9325
From wiki-pain
|
|
|
|
|
Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
The expression of IGF-1r immunopositive cells in the experimental group was also significantly lower than in the control. | |||||||||||||||
| |||||||||||||||
|
The objective of this in vitro study was to determine if continuous biophysical strain regulates the gene expression of IGF1, IGF2, IGF1 receptor (IGF1R), insulin receptor substrate (IRS1), and IGF-binding proteins (IGFBP) 3 and 5 in cells from the fibrocartilaginous disc of the temporomandibular joint (TMJ). | |||||||||||||||
| |||||||||||||||
|
The objective of this in vitro study was to determine if continuous biophysical strain regulates the gene expression of IGF1, IGF2, IGF1 receptor (IGF1R), insulin receptor substrate (IRS1), and IGF-binding proteins (IGFBP) 3 and 5 in cells from the fibrocartilaginous disc of the temporomandibular joint (TMJ). | |||||||||||||||
| |||||||||||||||
|
The gene expression of IGF1, IGF2, IGF1R, IRS1, IGFBP3, and IGFBP5 was significantly (p < 0.05) inhibited when cells were subjected to continuous biophysical strain, as compared to control at both time points. | |||||||||||||||
| |||||||||||||||
|
Repeated FLX increased both mRNA and IGF-1R levels in the FC. | |||||||||||||||
| |||||||||||||||
|
IGF-1 receptor (IGF-1R) protein expression and IGF-1 mRNA levels were assessed in rat frontal cortex (FC) and hippocampus, in FLX-treated [15 mg/kg, orally; 3 (acute) or 21 (repeated) days] male Wistar rats. | |||||||||||||||
| |||||||||||||||
|
Regulation of IRS-2 signaling by IGF-1 receptor in the diabetic rat heart. | |||||||||||||||
| |||||||||||||||
|
Acute FLX administration decreased IGF-1 mRNA levels in the FC and hippocampus and increased IGF-1R levels in the FC. | |||||||||||||||
| |||||||||||||||
|
Insulin receptor and IGF-I receptor (IGF-IR) expressions in DRGs and NGF content in sciatic nerve were significantly decreased in 7-month diabetic rats (P < 0.01, 0.05, and 0.005, respectively). | |||||||||||||||
| |||||||||||||||
|
We assessed the expression of IGF, IGF binding protein (IGFBP), and IGF receptor transcripts in liver, carcass, and placenta of fetal rats with IUGR resulting from unilateral uterine artery ligation. | |||||||||||||||
| |||||||||||||||
|
Expression of insulin receptor, IGF-1R, TrkA and C was decreased in BB/Wor rats, whereas BBZDR/Wor rats showed milder or no deficits. | |||||||||||||||
| |||||||||||||||
|
Furthermore, levels of IGF-receptor were significantly increased in tissues from hindlimb unloaded animals treated with IGF-I.
| |||||||||||||||
| |||||||||||||||
|
Thus, immune cells including T and B lymphocytes [50] and mononuclear cells [51] express IGF-1 receptor. | |||||||||||||||
| |||||||||||||||
|
Specimens from 12 patients were investigated histologically and immunohistochemically to obtain the distribution of the IGFs-I and -II and the IGF1 receptor. | |||||||||||||||
| |||||||||||||||
|
General Comments
This test has worked.