INT9326

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Context Info
Confidence 0.61
First Reported 1992
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.99
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Igfbp2) extracellular space (Igfbp2) aging (Igfbp2)
extracellular region (Igfbp2) response to stress (Igfbp2)
Anatomy Link Frequency
chondrocytes 1
liver 1
bone tissue 1
Igfbp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 4 96.44 Very High Very High Very High
cytokine 5 95.68 Very High Very High Very High
anesthesia 6 94.48 High High
Inflammation 8 50.40 Quite High
isoflurane 5 39.84 Quite Low
antagonist 10 14.32 Low Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
vagus nerve 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 38 99.84 Very High Very High Very High
Stress 3 97.76 Very High Very High Very High
Injury 8 94.28 High High
Sprains And Strains 4 78.52 Quite High
Body Weight 1 68.68 Quite High
Intrauterine Growth Retardation 4 63.00 Quite High
INFLAMMATION 12 50.40 Quite High
Bordatella Infection 3 41.08 Quite Low
Hypersensitivity 8 5.00 Very Low Very Low Very Low
Hypercalcemia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The four-point bending model [25] was used to generate a single period of dynamic loading of the right tibia in rats in vivo in order to detect acute changes of IGFBP-2 mRNA locally in bone tissue after stimulation by mechanical stress.
Regulation (changes) of IGFBP-2 mRNA in bone tissue associated with stress
1) Confidence 0.61 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0.17 Pain Relevance 0
It was demonstrated that the IGFBP-2 probe is specific because IGFBP-2 mRNA expression is present in the choroid plexus and the neurons of the medulla oblongata, as described earlier [28], and in the chondrocytes of the proliferative and hypertrophic zone of the growth plate [34].
Regulation (specific) of IGFBP-2 in chondrocytes associated with medulla
2) Confidence 0.45 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0.08 Pain Relevance 0.05
Serum immunoreactive IGFBP-2 was unchanged among the groups, indicating that IGFBP-1 accounted for the increase in doublet intensity.
Neg (unchanged) Regulation (unchanged) of IGFBP-2
3) Confidence 0.17 Published 1992 Journal Pediatr. Res. Section Abstract Doc Link 1408464 Disease Relevance 0.25 Pain Relevance 0.17
To investigate the beneficial effect of BRL-44408 in sepsis, we used an experimental sepsis model of CLP in rats receiving BRL-44408. 20 h later we measured cytokine levels in KCs, plasma and injury paramers for liver (AST & ALT), kidney (creatinine) and general oxigenation (lactate).
Spec (investigate) Regulation (effect) of BRL-44408 in liver associated with injury, sepsis and cytokine
4) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677660 Disease Relevance 0.49 Pain Relevance 0.07

General Comments

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