INT93281

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Context Info
Confidence 0.50
First Reported 2001
Last Reported 2006
Negated 0
Speculated 0
Reported most in Title
Documents 12
Total Number 13
Disease Relevance 5.55
Pain Relevance 10.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Folh1) plasma membrane (Folh1) nucleus (Folh1)
cytoplasm (Folh1)
Anatomy Link Frequency
Spinal 4
nerve 1
paw 1
skin 1
Folh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 48 100.00 Very High Very High Very High
Pain 33 100.00 Very High Very High Very High
Inflammation 12 100.00 Very High Very High Very High
Analgesic 10 100.00 Very High Very High Very High
nociceptor 8 100.00 Very High Very High Very High
Neuropathic pain 10 99.92 Very High Very High Very High
Antinociceptive 6 99.48 Very High Very High Very High
diabetic neuropathy 6 99.20 Very High Very High Very High
allodynia 35 99.08 Very High Very High Very High
Dorsal horn neuron 1 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 48 99.92 Very High Very High Very High
Nociception 3 99.54 Very High Very High Very High
Diabetic Neuropathy 8 99.20 Very High Very High Very High
Injury 12 98.70 Very High Very High Very High
Hypersensitivity 1 98.16 Very High Very High Very High
Diabetes Mellitus 4 98.00 Very High Very High Very High
Pain 5 97.12 Very High Very High Very High
Neurological Disease 3 96.28 Very High Very High Very High
Cv Unclassified Under Development 2 95.56 Very High Very High Very High
Nervous System Injury 2 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We suggest that N-acetylated-alpha-linked acidic dipeptidase plays an important role in spinal nociceptive transmission and that inhibition of spinal N-acetylated-alpha-linked acidic dipeptidase produces an antinociceptive effect during the rat formalin test but not during the hot plate test.
Negative_regulation (inhibition) of acidic dipeptidase in spinal associated with nociception and antinociceptive
1) Confidence 0.50 Published 2001 Journal Neuroscience Section Abstract Doc Link 11166133 Disease Relevance 0.16 Pain Relevance 0.26
Inhibition of spinal N-acetylated-alpha-linked acidic dipeptidase produces an antinociceptive effect in the rat formalin test.
Negative_regulation (Inhibition) of acidic dipeptidase in spinal associated with analgesic and antinociceptive
2) Confidence 0.50 Published 2001 Journal Neuroscience Section Title Doc Link 11166133 Disease Relevance 0.07 Pain Relevance 0.63
Recently, a specific inhibitor of N-acetylated-alpha-linked acidic dipeptidase, 2-(phosphonomethyl)pentanedioic acid, has been reported.
Negative_regulation (inhibitor) of acidic dipeptidase
3) Confidence 0.50 Published 2001 Journal Neuroscience Section Abstract Doc Link 11166133 Disease Relevance 0.08 Pain Relevance 0.53
Inhibition of glutamate carboxypeptidase II (GCP II) reduces glutamate release generated from N-acetyl-aspartyl-glutamate in nerve tissues and may have an analgesic effect on neuropathic pain.
Negative_regulation (Inhibition) of glutamate carboxypeptidase II in nerve associated with glutamate, analgesic and neuropathic pain
4) Confidence 0.47 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11805230 Disease Relevance 0.91 Pain Relevance 1.21
GCPII (NAALADase) inhibition prevents long-term diabetic neuropathy in type 1 diabetic BB/Wor rats.
Negative_regulation (inhibition) of GCPII associated with diabetes mellitus and diabetic neuropathy
5) Confidence 0.45 Published 2002 Journal J. Neurol. Sci. Section Title Doc Link 11809162 Disease Relevance 0.74 Pain Relevance 0.48
In the present study, we examined the role of spinal NAALADase in the maintenance of mechanical allodynia induced by carrageenan injection, skin incision and mild thermal injury using 2-(phosphonomethyl)pentanedioic acid (2-PMPA), a specific NAALADase inhibitor, in rats.
Negative_regulation (inhibitor) of NAALADase in skin associated with allodynia and injury
6) Confidence 0.43 Published 2001 Journal Brain Res. Section Abstract Doc Link 11478930 Disease Relevance 0.58 Pain Relevance 0.78
The preventive and therapeutic effects of GCPII (NAALADase) inhibition on painful and sensory diabetic neuropathy.
Negative_regulation (inhibition) of GCPII associated with pain and diabetic neuropathy
7) Confidence 0.43 Published 2006 Journal J. Neurol. Sci. Section Title Doc Link 16780883 Disease Relevance 0.56 Pain Relevance 1.10
The preventive and therapeutic effects of GCPII (NAALADase) inhibition on painful and sensory diabetic neuropathy.
Negative_regulation (inhibition) of NAALADase associated with pain and diabetic neuropathy
8) Confidence 0.43 Published 2006 Journal J. Neurol. Sci. Section Title Doc Link 16780883 Disease Relevance 0.56 Pain Relevance 1.10
Spinal N-acetyl-alpha-linked acidic dipeptidase (NAALADase) inhibition attenuates mechanical allodynia induced by paw carrageenan injection in the rat.
Negative_regulation (inhibition) of Spinal N-acetyl-alpha-linked acidic dipeptidase in Spinal associated with inflammation and allodynia
9) Confidence 0.43 Published 2001 Journal Brain Res. Section Title Doc Link 11478930 Disease Relevance 0.50 Pain Relevance 1.41
Spinal N-acetyl-alpha-linked acidic dipeptidase (NAALADase) inhibition attenuates mechanical allodynia induced by paw carrageenan injection in the rat.
Negative_regulation (inhibition) of NAALADase in Spinal associated with inflammation and allodynia
10) Confidence 0.43 Published 2001 Journal Brain Res. Section Title Doc Link 11478930 Disease Relevance 0.50 Pain Relevance 1.41
These data suggested that the inhibition of spinal NAALADase alleviated mechanical allodynia induced by paw carrageenan injection.
Negative_regulation (inhibition) of NAALADase in paw associated with allodynia
11) Confidence 0.38 Published 2001 Journal Brain Res. Section Abstract Doc Link 11478930 Disease Relevance 0.89 Pain Relevance 0.80
A series of 2-(thioalkyl)pentanedioic acids were synthesized and evaluated as inhibitors of glutamate carboxypeptidase II (GCP II, EC 3.4.17.21).
Negative_regulation (inhibitors) of glutamate carboxypeptidase II associated with glutamate
12) Confidence 0.37 Published 2003 Journal J. Med. Chem. Section Abstract Doc Link 12723961 Disease Relevance 0 Pain Relevance 0.19
Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor.
Negative_regulation (inhibitors) of glutamate carboxypeptidase II associated with glutamate and analgesic
13) Confidence 0.37 Published 2003 Journal J. Med. Chem. Section Title Doc Link 12723961 Disease Relevance 0 Pain Relevance 0.71

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