INT93293

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Context Info
Confidence 0.28
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.71
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv1) transmembrane transport (Trpv1) lipid metabolic process (Trpv1)
cytosol (Trpv1) extracellular space (Ngf) signal transduction (Ngf)
Anatomy Link Frequency
dorsal root ganglion 1
Ngf (Mus musculus)
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 81 100.00 Very High Very High Very High
Nerve growth factor 15 100.00 Very High Very High Very High
Lasting pain 7 99.92 Very High Very High Very High
Root ganglion neuron 3 98.36 Very High Very High Very High
Cancer pain 1 93.08 High High
antagonist 31 89.32 High High
Neuropeptide 3 76.68 Quite High
calcitonin gene related peptide 17 76.16 Quite High
Pain 30 61.92 Quite High
Osteoarthritis 1 48.16 Quite Low
Disease Link Frequency Relevance Heat
Pain 38 99.92 Very High Very High Very High
Ganglion Cysts 5 98.16 Very High Very High Very High
Nociception 17 95.84 Very High Very High Very High
Cancer Pain 1 93.08 High High
Bone Cancer 1 92.88 High High
Osteoarthritis 1 48.16 Quite Low
Neuropathic Pain 6 47.40 Quite Low
Coronary Artery Disease 2 20.56 Low Low
INFLAMMATION 21 5.00 Very Low Very Low Very Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NGF has been shown to sensitize TRPV1 by activating PLC and hydrolyzes PIP2, which tonically inhibits the channel [35, 139], or by activating PKC, PI3K [26, 35, 161, 167] and ERK [204].
NGF Regulation (sensitize) of TRPV1 associated with nerve growth factor
1) Confidence 0.28 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.35 Pain Relevance 0.72
Nerve growth factor regulates VR-1 mRNA levels in cultures of adult dorsal root ganglion neurons.
Nerve growth factor Regulation (regulates) of VR-1 in dorsal root ganglion associated with ganglion cysts, nerve growth factor and root ganglion neuron
2) Confidence 0.01 Published 2001 Journal Pain Section Title Doc Link 11166474 Disease Relevance 0.36 Pain Relevance 1.18

General Comments

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