INT93296

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Context Info
Confidence 0.64
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.48
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pmch) extracellular region (Pmch) nucleus (Pmch)
Anatomy Link Frequency
hypothalamus 3
Neurons 2
Pmch (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 6 100.00 Very High Very High Very High
Neurotransmitter 1 100.00 Very High Very High Very High
Glutamate 3 99.44 Very High Very High Very High
Serotonin 1 96.40 Very High Very High Very High
Dopamine 1 95.96 Very High Very High Very High
Enkephalin 3 94.60 High High
opioid receptor 2 84.80 Quite High
GABAergic 22 80.88 Quite High
narcan 3 75.12 Quite High
Opioid 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Sleep Disorders 10 96.68 Very High Very High Very High
Urological Neuroanatomy 38 67.76 Quite High
Generalized Anxiety Disorder 39 58.24 Quite High
Hyperphagia 3 57.12 Quite High
Primary Sclerosing Cholangitis 27 5.00 Very Low Very Low Very Low
Aids-related Complex 7 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Camurati-engelmann Disease 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Melanin-concentrating hormone (MCH) and orexin-A are orexigenic peptidergic neurotransmitters produced primarily in the lateral hypothalamus.
Gene_expression (produced) of Melanin-concentrating hormone in hypothalamus associated with neurotransmitter
1) Confidence 0.64 Published 2002 Journal Endocrinology Section Abstract Doc Link 12130565 Disease Relevance 0.06 Pain Relevance 0.38
Neurons from the lateral hypothalamus that synthesize melanin-concentrating hormone (MCH) play an important role in the regulation of energy homeostasis.
Gene_expression (synthesize) of melanin-concentrating hormone in hypothalamus
2) Confidence 0.56 Published 2003 Journal J. Neurophysiol. Section Abstract Doc Link 14573562 Disease Relevance 0 Pain Relevance 0
Neurons synthesizing melanin-concentrating hormone identified by selective reporter gene expression after transfection in vitro: transmitter responses.
Gene_expression (synthesizing) of melanin-concentrating hormone in Neurons
3) Confidence 0.56 Published 2003 Journal J. Neurophysiol. Section Title Doc Link 14573562 Disease Relevance 0 Pain Relevance 0.14
Hypocretin, melanin concentrating hormone, tyrosine hydroxylase, neuropeptide Y and gamma-aminobutyric acid are also found in subsets of PHA neurons, and fibers immunoreactive for these substances as well as for serotonin, dopamine-beta-hydroxylase and met-enkephalin are observed in the area and aid in the delineation of its borders.
Gene_expression (found) of melanin concentrating hormone in neurons associated with dopamine, neuropeptide, enkephalin and serotonin
4) Confidence 0.37 Published 2001 Journal Brain Res. Section Abstract Doc Link 11166682 Disease Relevance 0 Pain Relevance 0.29
overlaps with the region of cells expressing melanin-concentrating hormone (MCH) and hypocretin/orexin [28].
Gene_expression (expressing) of melanin-concentrating hormone
5) Confidence 0.14 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0.12 Pain Relevance 0.06
We further showed that some of the activated neurons of the tuberal hypothalamus express the melanin concentrating hormone (MCH) neuropeptide and that icv injection of MCH induces a strong increase in PS quantity.
Gene_expression (express) of melanin concentrating hormone in hypothalamus associated with neuropeptide
6) Confidence 0.14 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2909908 Disease Relevance 0.30 Pain Relevance 0.13

General Comments

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