INT933

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Context Info
Confidence 0.11
First Reported 1979
Last Reported 2004
Negated 2
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 2.30
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Gtf3a) nucleus (Gtf3a) intracellular (Gtf3a)
DNA binding (Gtf3a)
Anatomy Link Frequency
hypothalamus 2
blood 2
plasma 2
neurons 2
mesothelial cells 2
Gtf3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 5 100.00 Very High Very High Very High
cytokine 1 100.00 Very High Very High Very High
c fibre 3 96.16 Very High Very High Very High
fibrosis 2 94.72 High High
fluoxetine 2 88.00 High High
qutenza 3 87.24 High High
Serotonin 3 86.88 High High
Clonidine 3 85.44 High High
ischemia 2 75.00 Quite High
Pain 3 71.72 Quite High
Disease Link Frequency Relevance Heat
Natriuresis 3 100.00 Very High Very High Very High
Hypotension 1 100.00 Very High Very High Very High
Renal Failure 46 99.40 Very High Very High Very High
Toxicity 2 99.10 Very High Very High Very High
Injury 3 99.06 Very High Very High Very High
Increased Venous Pressure Under Development 4 98.36 Very High Very High Very High
Fibrosis 3 94.72 High High
Hypertension 4 82.32 Quite High
Reperfusion Injury 1 75.00 Quite High
Cv Unclassified Under Development 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The heart has an endocrine activity which depends on the secretion of a natriuretic, diuretic and hypotensive factor contained in osmophilic, secretory granules localized in the myocardiocytes and called "atrial specific granules" (the atrial natriuretic factor, ANF).
Regulation (depends) of Localization (secretion) of factor in heart associated with natriuresis and hypotension
1) Confidence 0.11 Published 1993 Journal Medicina (B Aires) Section Abstract Doc Link 8084246 Disease Relevance 0.58 Pain Relevance 0.06
The possible involvement of adrenergic mechanisms in regulating the secretion of growth hormone (GH)-releasing factor (GRF) from the rat hypothalamus was examined in vitro with a perifusion system.
Regulation (regulating) of Localization (secretion) of factor in hypothalamus
2) Confidence 0.09 Published 1986 Journal Endocrinology Section Abstract Doc Link 2873027 Disease Relevance 0 Pain Relevance 0.21
We examined the effect of a 30% blood volume expansion with either blood, isotonic saline, or isotonic saline plus albumin on the release of immunoreactive-atrial natriuretic factor (IR-ANF) in conscious and barbiturate-anesthetized rats.
Spec (examined) Regulation (effect) of Localization (release) of factor in blood associated with natriuresis
3) Confidence 0.06 Published 1990 Journal J Pharmacol Methods Section Abstract Doc Link 2139484 Disease Relevance 0.10 Pain Relevance 0
Acute and chronic toxicity of standard PD fluids to mesothelial cells, affecting cell turnover and the pattern of growth factor and cytokine release, is considered a key mechanism underlying the progressive transformation of the peritoneum.
Regulation (affecting) of Localization (release) of factor in mesothelial cells associated with toxicity, renal failure and cytokine
4) Confidence 0.05 Published 2004 Journal BMC Nephrol Section Body Doc Link PMC529259 Disease Relevance 1.15 Pain Relevance 0.17
This prolactin-releasing factor (PRF)-like activity was not altered in plasma from rats treated with bromocryptine or chlorpromazine despite significant suppression and stimulation of plasma PRL levels, respectively.
Neg (not) Regulation (altered) of Localization (releasing) of factor in plasma
5) Confidence 0.04 Published 1979 Journal Neuroendocrinology Section Abstract Doc Link 114870 Disease Relevance 0 Pain Relevance 0.28
This study shows, for the first time, that PAR2 activation causes endothelium-dependent coronary vasodilation that is preserved after I/R injury and is not mediated by NO or prostanoids, but involves the release of an endothelium-derived hyperpolarizing factor (EDHF), possibly a lipoxygenase-derived eicosanoid, and activation of VR1 receptors on sensory C-fibers.
Neg (not) Regulation (involves) of Localization (release) of factor in endothelium associated with c fibre, injury and increased venous pressure under development
6) Confidence 0.03 Published 2002 Journal Circ. Res. Section Abstract Doc Link 11884377 Disease Relevance 0.47 Pain Relevance 0.41
One of the functions of glial receptors is to regulate synthesis and release of a variety of neuropeptides and growth factor peptides, which in turn act on neurons or other glia.
Regulation (regulate) of Localization (release) of factor in neurons associated with neuropeptide
7) Confidence 0.02 Published 1994 Journal Glia Section Abstract Doc Link 7927646 Disease Relevance 0 Pain Relevance 0.34

General Comments

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