INT93306

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Context Info
Confidence 0.18
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.07
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TRPV1, CAP1) transport (TRPV1) cell morphogenesis (CAP1)
cytoplasm (CAP1) lipid metabolic process (TRPV1) cytosol (TRPV1)
TRPV1 (Homo sapiens)
CAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 14 100.00 Very High Very High Very High
Potency 4 84.48 Quite High
agonist 19 75.00 Quite High
Root ganglion neuron 1 75.00 Quite High
Nicotine 16 68.24 Quite High
Glutamate 28 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Acupuncture 3 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 1 75.00 Quite High
Targeted Disruption 14 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low
Taste Disorders 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Blister 1 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the difference in pharmacological profiles of VR1 and the native channels suggests the possible presence of subtypes of the CAP receptor or regulatory mechanisms associated with VR1.
VR1 Binding (associated) of CAP associated with qutenza
1) Confidence 0.18 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11166956 Disease Relevance 0.07 Pain Relevance 0.88
These results suggest that the binding of RTX or CAP to an intracellular-binding site on the TRPV1t alters the conformation of the channel and sensitizes the channel to further stimulation by GalA-MRP.
TRPV1t Binding (binding) of CAP
2) Confidence 0.04 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0 Pain Relevance 0.10

General Comments

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