INT93309

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 11.40
Pain Relevance 9.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CAP1) cell morphogenesis (CAP1) plasma membrane (CAP1)
cytoskeleton organization (CAP1) cytoplasm (CAP1)
Anatomy Link Frequency
sensory neurons 1
brain 1
CAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 332 100.00 Very High Very High Very High
abdominal pain 144 100.00 Very High Very High Very High
cva 824 99.80 Very High Very High Very High
aspirin 56 98.80 Very High Very High Very High
c fibre 64 95.48 Very High Very High Very High
agonist 43 94.40 High High
Potency 1 92.72 High High
local anesthetic 4 85.08 High High
potassium channel 4 84.04 Quite High
sodium channel 4 79.04 Quite High
Disease Link Frequency Relevance Heat
Abdominal Pain 144 100.00 Very High Very High Very High
Pneumonia 96 100.00 Very High Very High Very High
Cv General 3 Under Development 798 99.80 Very High Very High Very High
Death 28 99.76 Very High Very High Very High
Anaemia 94 99.18 Very High Very High Very High
Hemophilus Infection 6 98.88 Very High Very High Very High
Cerebral Hypoxia 30 98.36 Very High Very High Very High
Infection 46 97.94 Very High Very High Very High
Ulcers 4 97.74 Very High Very High Very High
Inflammatory Bowel Disease 6 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The order of aspirin release from the microcapsules containing various polymers followed CAP > CAP + EC > EC.
Positive_regulation (followed) of CAP associated with aspirin
1) Confidence 0.43 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3002828 Disease Relevance 0 Pain Relevance 0.28
The order of aspirin release from the microcapsules containing various polymers followed CAP > CAP + EC > EC.
Positive_regulation (followed) of CAP associated with aspirin
2) Confidence 0.43 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3002828 Disease Relevance 0 Pain Relevance 0.28
In contrast, resiniferatoxin and its analog, phorbol 12-phenylacetate 13-acetate 20-homovanillate, was more potent in activating the CAP-activated channels in cultured sensory neurons than VR1.
Positive_regulation (activating) of CAP in sensory neurons associated with qutenza
3) Confidence 0.15 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11166956 Disease Relevance 0.07 Pain Relevance 0.92
A history of abdominal surgery, a family history for IBD or Helicobacter pylori infection and faecal pathogens had a prevalence <10%; therefore, the study will have less power to detect small increases in risk for persisting CAP in children with these determinants with equal precision (?
Positive_regulation (increases) of CAP associated with inflammatory bowel disease, abdominal pain, ulcers and infection
4) Confidence 0.15 Published 2010 Journal BMC Fam Pract Section Body Doc Link PMC2858717 Disease Relevance 0.93 Pain Relevance 0.49
We aim to detect a relative risk (RR) of 2 for CAP at 12 months, i.e. in the presence of a prognostic factor the probability of CAP at 12 months will increase to 60%.
Positive_regulation (increase) of CAP associated with abdominal pain
5) Confidence 0.15 Published 2010 Journal BMC Fam Pract Section Body Doc Link PMC2858717 Disease Relevance 0.91 Pain Relevance 0.82
An increased CAP Index is associated with death, poor neurological outcome, and increased interventions to lower ICP.
Positive_regulation (increased) of CAP associated with cva and death
6) Confidence 0.10 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.47 Pain Relevance 0.60
When the CAP Index is increased, there is no relationship between MAP and ICP.
Positive_regulation (increased) of CAP associated with cva
7) Confidence 0.10 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.25 Pain Relevance 0.52
Anemia was surprisingly common in hospitalized CAP, increasing with illness severity and greater in those with comorbid illnesses, female gender, and poor outcomes.
Positive_regulation (increasing) of CAP associated with anaemia and pneumonia
8) Confidence 0.08 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2848211 Disease Relevance 1.03 Pain Relevance 0
We tested much higher concentrations of CAP in otherwise CAP-resistant, A-type BRs (# 10 ?
Positive_regulation (concentrations) of CAP associated with qutenza
9) Confidence 0.07 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0.06 Pain Relevance 1.15
Second, very high concentrations of CAP but not RTX (>10 ?
Positive_regulation (concentrations) of CAP associated with qutenza
10) Confidence 0.07 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0 Pain Relevance 0.70
An increasing CAP Index indicates a modest reduction in MAP and substantial increase in ICP (Table 6).
Positive_regulation (increasing) of CAP associated with cva
11) Confidence 0.07 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 0.88 Pain Relevance 0.40
The CAP Index is increased with death, poor neurological outcome, and need for interventions to lower ICP (Table 7).
Positive_regulation (increased) of CAP associated with cva and death
12) Confidence 0.07 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.03 Pain Relevance 0.46
Study findings indicate that cerebral hypoxia occurs and brain wave patterns are altered when ICP increases, CPP decreases, or CAP Index increases.
Positive_regulation (increases) of CAP in brain associated with cerebral hypoxia and cva
13) Confidence 0.07 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.10 Pain Relevance 0.41
When there is no relationship between MAP and ICP, increasing MAP typically will not increase ICP [15,22,23] Thus, when the CAP Index is increased and ICP cannot be reduced, increasing MAP may improve CPP.
Positive_regulation (increased) of CAP associated with cva
14) Confidence 0.07 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.15 Pain Relevance 0.43
Single fiber baroreceptor responses to CAP
Positive_regulation (responses) of CAP associated with qutenza
15) Confidence 0.06 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0 Pain Relevance 0.72
However in A-type BRs, the high concentrations of CAP produced multiple, global changes in the pressure-discharge relations, changes that are consistent with multiple targets of action.
Positive_regulation (concentrations) of CAP associated with qutenza
16) Confidence 0.06 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0 Pain Relevance 0.88
Concentrations of sTREM-1 in serum are particularly increased in CAP caused by Gram-positive cocci and Haemophilus species.
Positive_regulation (increased) of CAP associated with hemophilus infection and pneumonia
17) Confidence 0.01 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2955686 Disease Relevance 0.76 Pain Relevance 0.03
Concentrations of sTREM-1 in serum are particularly increased in CAP caused by Gram-positive cocci and Haemophilus species.
Positive_regulation (caused) of CAP associated with hemophilus infection and pneumonia
18) Confidence 0.01 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2955686 Disease Relevance 0.76 Pain Relevance 0.03

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