INT9331

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Context Info
Confidence 0.33
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.00
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igfbp1) extracellular region (Igfbp1)
Anatomy Link Frequency
plasma 4
skeletal muscle 2
Igfbp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 42 93.80 High High
anesthesia 27 88.96 High High
corticosteroid 6 77.20 Quite High
analgesia 10 65.04 Quite High
qutenza 6 50.00 Quite Low
nociceptor 4 10.00 Low Low
Analgesic 6 5.00 Very Low Very Low Very Low
Action potential 6 5.00 Very Low Very Low Very Low
Catecholamine 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 44 93.80 High High
Sepsis 34 91.68 High High
Injury 5 91.60 High High
Critical Illness 78 91.44 High High
Diabetes Mellitus 7 91.20 High High
Postoperative Complications 1 87.28 High High
Muscle Disease 82 79.20 Quite High
Muscle Weakness 8 78.44 Quite High
Coronary Artery Disease 1 72.20 Quite High
Cognitive Disorder 1 69.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results suggest that increased serum IGFBP-1 concentrations may decrease IGF activity in serum and thus inhibit IGF-stimulated cell proliferation or, by crossing the endothelial border, inhibit the activity of locally produced IGF.
Negative_regulation (decrease) of Positive_regulation (increased) of IGFBP-1
1) Confidence 0.33 Published 1992 Journal Pediatr. Res. Section Abstract Doc Link 1408464 Disease Relevance 0.22 Pain Relevance 0.16
In agreement with other reports [21,22] we consider increased IGFBP-1 as a parameter indicative of impaired insulin sensitivity.
Negative_regulation (impaired) of Positive_regulation (increased) of IGFBP-1
2) Confidence 0.33 Published 2010 Journal Crit Care Section Body Doc Link PMC2911767 Disease Relevance 0.76 Pain Relevance 0.13
In vitro [33] and later in vivo [14], it has been shown that an increase of IGFBP-1 reduced the IGF-I-mediated glucose uptake and reduced protein synthesis in skeletal muscle within an experimental setting.
Negative_regulation (reduced) of Positive_regulation (increase) of IGFBP-1 in skeletal muscle
3) Confidence 0.33 Published 2010 Journal Crit Care Section Body Doc Link PMC2911767 Disease Relevance 1.12 Pain Relevance 0.29
The sepsis-induced decrease in hepatic IGF-I mRNA and circulating IGF-I (26%), as well as the 4-fold increase in plasma IGFBP-1 and hepatic IGFBP-1 mRNA were prevented by capsaicin.
Negative_regulation (prevented) of Positive_regulation (increase) of IGFBP-1 in plasma
4) Confidence 0.28 Published 2003 Journal J. Surg. Res. Section Body Doc Link 12888332 Disease Relevance 0.11 Pain Relevance 0
The sepsis-induced decrease in hepatic IGF-I mRNA and circulating IGF-I (26%), as well as the 4-fold increase in plasma IGFBP-1 and hepatic IGFBP-1 mRNA were prevented by capsaicin.
Negative_regulation (prevented) of Positive_regulation (increase) of IGFBP-1 in plasma
5) Confidence 0.28 Published 2003 Journal J. Surg. Res. Section Body Doc Link 12888332 Disease Relevance 0.11 Pain Relevance 0
In particular, amino acid infusion before and during surgery totally abolished the increase in insulin, and diminished the increase in IGFBP-1 and HOMA seen in the other operated groups on the first postoperative day.
Negative_regulation (diminished) of Positive_regulation (increase) of IGFBP-1
6) Confidence 0.19 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC1779788 Disease Relevance 0.68 Pain Relevance 0

General Comments

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