INT93310

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Context Info
Confidence 0.58
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 3.07
Pain Relevance 8.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CAP1) cell morphogenesis (CAP1) plasma membrane (CAP1)
cytoskeleton organization (CAP1) cytoplasm (CAP1)
Anatomy Link Frequency
sensory neurons 1
nerve 1
aortic arch 1
CAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 654 100.00 Very High Very High Very High
c fibre 128 100.00 Very High Very High Very High
agonist 75 100.00 Very High Very High Very High
Action potential 80 98.72 Very High Very High Very High
Nicotine 16 95.68 Very High Very High Very High
alcohol 11 95.16 Very High Very High Very High
Inflammation 11 87.00 High High
aspirin 56 82.16 Quite High
unmyelinated 16 75.28 Quite High
Root ganglion neuron 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Pneumonia 70 100.00 Very High Very High Very High
Anaemia 94 98.24 Very High Very High Very High
Disease 1 95.72 Very High Very High Very High
Disorder Of Lipid Metabolism 23 91.92 High High
INFLAMMATION 11 87.00 High High
Toxicity 8 84.64 Quite High
Renal Failure 1 80.72 Quite High
Infection 7 79.96 Quite High
Cancer 1 79.48 Quite High
Cardiovascular Disease 10 79.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The drug content was found to be higher in CAP microcapsules followed by EC and CAP+EC as depicted in (Table 2).
Gene_expression (microcapsules) of CAP
1) Confidence 0.58 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3002828 Disease Relevance 0 Pain Relevance 0.10
Studies revealed that EC based microcapsules were larger than CAP, and EC + CAP based microcapsules.
Gene_expression (larger) of CAP
2) Confidence 0.58 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3002828 Disease Relevance 0 Pain Relevance 0.09
Numerous rules were built in order to assess the prognosis of CAP.
Gene_expression (prognosis) of CAP associated with pneumonia
3) Confidence 0.28 Published 2008 Journal The Open Respiratory Medicine Journal Section Body Doc Link PMC2606649 Disease Relevance 0.32 Pain Relevance 0
Heterologously expressed vanilloid receptor 1 (VR1), a cloned cDNA encoding for capsaicin (CAP)-sensitive currents, resembles the native CAP channels in cultured sensory neurons in channel property.
Gene_expression (expressed) of CAP in sensory neurons associated with qutenza
4) Confidence 0.17 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11166956 Disease Relevance 0.07 Pain Relevance 0.75
We did not have access to pre-CAP hemoglobin levels, and were therefore unable to determine if anemia preceded the development of pneumonia.
Gene_expression (levels) of CAP associated with anaemia and pneumonia
5) Confidence 0.13 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2848211 Disease Relevance 1.74 Pain Relevance 0.15
Second, very high concentrations of CAP but not RTX (>10 ?
Gene_expression (>10) of CAP associated with qutenza
6) Confidence 0.10 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0 Pain Relevance 0.70
We tested much higher concentrations of CAP in otherwise CAP-resistant, A-type BRs (# 10 ?
Gene_expression (otherwise) of CAP associated with qutenza
7) Confidence 0.09 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0.06 Pain Relevance 1.20
The CAP resistant component of the whole nerve measurements during ADN conduction was within the A?
Gene_expression (resistant) of CAP in nerve associated with qutenza
8) Confidence 0.09 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0 Pain Relevance 0.83
CAP was initially dissolved in DMSO and then mixed with PBS to a concentrated stock solution containing 300 ?
Gene_expression (mixed) of CAP associated with qutenza
9) Confidence 0.09 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0 Pain Relevance 0.50
Despite these limitations of the single fiber BR recordings, the ADN ENG results bolster the association of C-type BRs with CAP sensitivity and A-type BRs with CAP resistance consistent with other studies [27].
Gene_expression (resistance) of CAP associated with qutenza
10) Confidence 0.09 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0.15 Pain Relevance 0.78
M CAP blocked C-fiber conduction in the ADN within 10 min but appeared to be specific in that A-fibers were not blocked [33].
Gene_expression (specific) of CAP associated with c fibre and qutenza
11) Confidence 0.09 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0.07 Pain Relevance 1.07
M CAP, the BR was nearly inexcitable and only fired a scattering of action potentials to aortic arch pressures above its control threshold level (Figure 3).
Gene_expression (inexcitable) of CAP in aortic arch associated with action potential and qutenza
12) Confidence 0.09 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0 Pain Relevance 0.78
We tested much higher concentrations of CAP in otherwise CAP-resistant, A-type BRs (# 10 ?
Gene_expression (resistant) of CAP associated with qutenza
13) Confidence 0.09 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0.06 Pain Relevance 1.20
Although the vanilloids (RTX and CAP) are the most potent agonists of TRPV1t (Lyall et al. 2004, 2005c), they are extremely pungent and thus have a strong trigeminal component.
Gene_expression (agonists) of CAP associated with agonist
14) Confidence 0.06 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0 Pain Relevance 0.39
Whole-genome genotypes for CAP and PRINCE participants were measured in two stages (henceforth referred to as Stage I and Stage II).
Gene_expression (participants) of CAP
15) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842298 Disease Relevance 0.59 Pain Relevance 0

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