INT93339

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Context Info
Confidence 0.10
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.73
Pain Relevance 4.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Naalad2) cellular_component (Naalad2)
Anatomy Link Frequency
brain 2
brainstem 1
interneurons 1
Naalad2 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 52 100.00 Very High Very High Very High
Neurotransmitter 12 99.96 Very High Very High Very High
medulla 3 98.64 Very High Very High Very High
Pain 49 97.72 Very High Very High Very High
Glutamate receptor 14 97.00 Very High Very High Very High
analgesia 34 96.16 Very High Very High Very High
agonist 18 95.16 Very High Very High Very High
antagonist 18 91.44 High High
Analgesic 24 90.64 High High
insula 26 90.60 High High
Disease Link Frequency Relevance Heat
Toxicity 2 98.76 Very High Very High Very High
Pain 51 97.72 Very High Very High Very High
Inflammatory Pain 24 86.96 High High
Headache 69 84.28 Quite High
Neuropathic Pain 8 54.44 Quite High
INFLAMMATION 10 53.60 Quite High
Nociception 6 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 4 5.00 Very Low Very Low Very Low
Bone Cancer 4 5.00 Very Low Very Low Very Low
Overdose 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NAAG and its receptors are present in circuits within the brain and brainstem that process pain perception.
Gene_expression (present) of NAAG in brain associated with pain and medulla
1) Confidence 0.10 Published 2008 Journal Mol Pain Section Body Doc Link PMC2517065 Disease Relevance 0.69 Pain Relevance 1.18
NAAG and its receptors are present in circuits within the brain and brainstem that process pain perception.
Gene_expression (present) of NAAG in brainstem associated with pain and medulla
2) Confidence 0.03 Published 2008 Journal Mol Pain Section Body Doc Link PMC2517065 Disease Relevance 0.69 Pain Relevance 1.18
Rat cortical interneurons express both NAAG and glutamic acid decarboxylase, as well as mGluR3 mRNA.
Gene_expression (express) of NAAG in interneurons
3) Confidence 0.01 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11168538 Disease Relevance 0 Pain Relevance 0.57
In addition to its role as a neurotransmitter, NAAG is a source of Glu [64] and like NAA is thought to play a role as a major osmolyte in the vertebrate brain [65,66].
Gene_expression (source) of NAAG in brain associated with glutamate and neurotransmitter
4) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714306 Disease Relevance 0.35 Pain Relevance 1.10

General Comments

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