INT9334

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Context Info
Confidence 0.54
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 24
Disease Relevance 9.30
Pain Relevance 4.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igfbp1) extracellular region (Igfbp1)
Anatomy Link Frequency
plasma 2
hepatocyte 2
skeletal muscle 1
band 1
pole 1
Igfbp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 360 100.00 Very High Very High Very High
opiate 1 100.00 Very High Very High Very High
narcan 5 99.98 Very High Very High Very High
Inflammation 71 99.82 Very High Very High Very High
cytokine 215 98.28 Very High Very High Very High
Opioid 1 98.06 Very High Very High Very High
anesthesia 116 97.68 Very High Very High Very High
corticosteroid 9 76.56 Quite High
analgesia 23 65.04 Quite High
qutenza 6 50.00 Quite Low
Disease Link Frequency Relevance Heat
Critical Illness 163 99.84 Very High Very High Very High
INFLAMMATION 73 99.82 Very High Very High Very High
Obesity 11 99.38 Very High Very High Very High
Insulin Resistance 24 98.60 Very High Very High Very High
Polycystic Ovary Syndrome 9 98.48 Very High Very High Very High
Bronchopulmonary Dysplasia 80 98.40 Very High Very High Very High
Sepsis 197 97.52 Very High Very High Very High
Hyperinsulinism 13 95.04 Very High Very High Very High
Intrauterine Growth Retardation 16 94.28 High High
Body Weight 66 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum IGFBP, analyzed by ligand blot, showed a 2.4-fold increase in the doublet IGFBP-1/-2 band in UA-lig fetuses.
Positive_regulation (increase) of IGFBP-1 in band
1) Confidence 0.54 Published 1992 Journal Pediatr. Res. Section Abstract Doc Link 1408464 Disease Relevance 0.26 Pain Relevance 0.18
Our results suggest that increased serum IGFBP-1 concentrations may decrease IGF activity in serum and thus inhibit IGF-stimulated cell proliferation or, by crossing the endothelial border, inhibit the activity of locally produced IGF.
Positive_regulation (increased) of IGFBP-1
2) Confidence 0.54 Published 1992 Journal Pediatr. Res. Section Abstract Doc Link 1408464 Disease Relevance 0.22 Pain Relevance 0.16
In agreement with other reports [21,22] we consider increased IGFBP-1 as a parameter indicative of impaired insulin sensitivity.
Positive_regulation (increased) of IGFBP-1
3) Confidence 0.53 Published 2010 Journal Crit Care Section Body Doc Link PMC2911767 Disease Relevance 0.75 Pain Relevance 0.13
In vitro [33] and later in vivo [14], it has been shown that an increase of IGFBP-1 reduced the IGF-I-mediated glucose uptake and reduced protein synthesis in skeletal muscle within an experimental setting.
Positive_regulation (increase) of IGFBP-1 in skeletal muscle
4) Confidence 0.53 Published 2010 Journal Crit Care Section Body Doc Link PMC2911767 Disease Relevance 1.07 Pain Relevance 0.29
The sepsis-induced decrease in hepatic IGF-I mRNA and circulating IGF-I (26%), as well as the 4-fold increase in plasma IGFBP-1 and hepatic IGFBP-1 mRNA were prevented by capsaicin.
Positive_regulation (increase) of IGFBP-1 in plasma
5) Confidence 0.45 Published 2003 Journal J. Surg. Res. Section Body Doc Link 12888332 Disease Relevance 0.11 Pain Relevance 0
The sepsis-induced decrease in hepatic IGF-I mRNA and circulating IGF-I (26%), as well as the 4-fold increase in plasma IGFBP-1 and hepatic IGFBP-1 mRNA were prevented by capsaicin.
Positive_regulation (increase) of IGFBP-1 in plasma
6) Confidence 0.45 Published 2003 Journal J. Surg. Res. Section Body Doc Link 12888332 Disease Relevance 0.11 Pain Relevance 0
Impairment of IGF-I may be due to inflammation-induced upregulation of high-affinity IGFBP-1 which prevents IGF-I receptor binding [32].
Positive_regulation (upregulation) of IGFBP-1 associated with inflammation
7) Confidence 0.36 Published 2010 Journal Crit Care Section Body Doc Link PMC2911767 Disease Relevance 1.15 Pain Relevance 0.29
IGFBP-I was increased in CLP animals compared with sham and increased in starved animals compared with those receiving nutrition.
Positive_regulation (increased) of IGFBP-I
8) Confidence 0.28 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.33 Pain Relevance 0.26
IGFBP-I was increased in CLP animals compared with sham and increased in starved animals compared with those receiving nutrition.
Positive_regulation (increased) of IGFBP-I
9) Confidence 0.28 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.32 Pain Relevance 0.25
PN also resulted in significantly lower IGFBP-I levels compared with EN in septic animals, despite the greater recovery of IL-6 and IL-10 in PN-fed animals with sepsis.
Positive_regulation (resulted) of IGFBP-I associated with sepsis and cytokine
10) Confidence 0.28 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.46 Pain Relevance 0.19
From baseline to the first postoperative day there was a significant increase in group B and C in HOMA (from 0.8 to1.3 and 1.2 to1.8 respectively; p < 0.05, Figure 9) and IGFBP-1 (from 35 to45 ?
Positive_regulation (increase) of IGFBP-1
11) Confidence 0.27 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC1779788 Disease Relevance 0 Pain Relevance 0
In particular, amino acid infusion before and during surgery totally abolished the increase in insulin, and diminished the increase in IGFBP-1 and HOMA seen in the other operated groups on the first postoperative day.
Positive_regulation (increase) of IGFBP-1
12) Confidence 0.22 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC1779788 Disease Relevance 0.67 Pain Relevance 0
From baseline to the first postoperative day there was a significant increase in HOMA and IGFBP-1 in groups B and C.
Positive_regulation (increase) of IGFBP-1
13) Confidence 0.21 Published 2007 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC1779788 Disease Relevance 0.23 Pain Relevance 0.25
From earlier studies it is known that obesity, low levels of IGFBP-1 and an increased IGF-1:IGFBP-1 ratio are factors associated with insulin resistance in men and women [49,51].
Positive_regulation (increased) of IGFBP-1 associated with obesity and insulin resistance
14) Confidence 0.21 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC1779788 Disease Relevance 0.38 Pain Relevance 0
In several animal models cascades of IGFBP-1 mRNA could be induced by stimulation of IGFBP-1 promoter activity (Suwanichkul et al 1994; Gan et al 2005), via the insulin-independent kinases (Lewitt 2001), by stabilisation of IGFP-1 mRNA (Luo et al 1990; Uchijima et al 1999) and a synergy of the glucocorticoid receptor and the hepatocyte nuclear factor 1 (HNF1) (Suh and Rechler 1997; Suh et al 1995).
Positive_regulation (induced) of IGFBP-1 in hepatocyte
15) Confidence 0.20 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721283 Disease Relevance 0.17 Pain Relevance 0.15
In the infants treated with dexamethasone IGFBP-1 levels were significantly enhanced, irrespectively if they were diagnosed BPD or not.
Positive_regulation (enhanced) of IGFBP-1 associated with bronchopulmonary dysplasia and dexamethasone
16) Confidence 0.20 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721283 Disease Relevance 0.24 Pain Relevance 0.29
[10], and circulating IGFBP-I levels are frequently elevated in critically ill patients on intensive care unit admission [11].
Positive_regulation (elevated) of IGFBP-I associated with critical illness
17) Confidence 0.19 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.29 Pain Relevance 0.27
In several animal models cascades of IGFBP-1 mRNA could be induced by stimulation of IGFBP-1 promoter activity (Suwanichkul et al 1994; Gan et al 2005), via the insulin-independent kinases (Lewitt 2001), by stabilisation of IGFP-1 mRNA (Luo et al 1990; Uchijima et al 1999) and a synergy of the glucocorticoid receptor and the hepatocyte nuclear factor 1 (HNF1) (Suh and Rechler 1997; Suh et al 1995).
Positive_regulation (stimulation) of IGFBP-1 promoter in hepatocyte
18) Confidence 0.18 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721283 Disease Relevance 0.17 Pain Relevance 0.15
g/l, p = 0.045) were significantly reduced under the influence of glucocorticoids, whereas IGFBP-1 was elevated (59.6 ± 61.0 vs 21.1 ± 21.7 ?
Positive_regulation (elevated) of IGFBP-1
19) Confidence 0.18 Published 2007 Journal Biologics : Targets & Therapy Section Abstract Doc Link PMC2721283 Disease Relevance 0.09 Pain Relevance 0.28
IGFBP-1 was reduced 1 and 2 weeks after dexamethasone and GH therapy, but 7 weeks after treatment IGFBP-1 concentrations were significantly elevated (Hammon et al 2003).
Positive_regulation (elevated) of IGFBP-1 associated with dexamethasone
20) Confidence 0.18 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721283 Disease Relevance 0.26 Pain Relevance 0.27

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