INT93341

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Context Info
Confidence 0.59
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.04
Pain Relevance 2.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkaca) nucleoplasm (Prkaca) mitochondrion (Prkaca)
Golgi apparatus (Prkaca) plasma membrane (Prkaca) nucleus (Prkaca)
Anatomy Link Frequency
neurons 2
brain 1
epithelium 1
Prkaca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 9 100.00 Very High Very High Very High
addiction 1 100.00 Very High Very High Very High
gABA 11 99.98 Very High Very High Very High
adenocard 10 99.08 Very High Very High Very High
agonist 14 98.68 Very High Very High Very High
Neurotransmitter 3 98.20 Very High Very High Very High
Migraine 2 96.44 Very High Very High Very High
Inflammation 3 95.48 Very High Very High Very High
Glutamate receptor 3 94.12 High High
MU agonist 1 88.04 High High
Disease Link Frequency Relevance Heat
Convulsion 63 99.10 Very High Very High Very High
Constipation 78 96.60 Very High Very High Very High
Headache 4 96.44 Very High Very High Very High
Neurogenic Inflammation 1 95.92 Very High Very High Very High
Nociception 18 89.20 High High
Death 12 89.08 High High
Apoptosis 25 88.48 High High
Cystic Fibrosis 4 87.84 High High
Epilepsy 19 83.92 Quite High
Cluster Headache 1 80.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PKA regulatory subunits were found in close vicinity to the plasma membrane in these neurons, and PKA catalytic subunits only translocated to the cell periphery when activated.
Localization (translocated) of PKA in neurons
1) Confidence 0.59 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12040081 Disease Relevance 0.53 Pain Relevance 0.51
Our findings indicate that primary culture from PTZ-induced seizure model triggers robust caspase-3 activation, release of cytochrome-c and decrease GABAB1R expression which has further decreasing effect on PKA expression level in hippocampal neurons of prenatal rat brain, while the co treatment of baclofen and phaclofen reverse the effects of PTZ and provide neuroprotection.
Localization (release) of PKA in brain associated with convulsion
2) Confidence 0.41 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0.71 Pain Relevance 0.03
Taken together, the present data confirm the PKA-dependence of forskolin-stimulated CGRP release and suggest that A(1) adenosine agonists may warrant further investigation in models of migraine and neurogenic inflammation.
Localization (release) of PKA associated with addiction, adenocard, inflammation, migraine, agonist, neurogenic inflammation and calcitonin gene-related peptide
3) Confidence 0.27 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11353815 Disease Relevance 0.27 Pain Relevance 0.98
NAAG inhibits KCl-induced [(3)H]-GABA release via mGluR3, cAMP, PKA and L-type calcium conductance.
Localization (release) of PKA associated with gaba
4) Confidence 0.16 Published 2001 Journal Eur. J. Neurosci. Section Title Doc Link 11168538 Disease Relevance 0 Pain Relevance 0.68
As elucidated in several studies, CFTR activation is normally regulated by ATP release, elevation of cytosolic cAMP [26] and protein kinase A (PKA).
Localization (release) of PKA
5) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553183 Disease Relevance 0 Pain Relevance 0
secretion in colonic epithelium via a signaling pathway involving cAMP and PKA, hence provide an osmotic force for subsequent colonic fluid secretion by which the laxative effect observed in the rat constipation model.
Localization (secretion) of PKA in epithelium associated with constipation
6) Confidence 0.09 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2553183 Disease Relevance 0.52 Pain Relevance 0.04
In the MS/CI neurons treated with PKA inhibitor RP-cAMPs (25 ?
Localization (treated) of PKA in neurons
7) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC2936373 Disease Relevance 0 Pain Relevance 0.04

General Comments

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