INT9335

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Context Info
Confidence 0.72
First Reported 1989
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 18
Total Number 20
Disease Relevance 12.76
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Igf2) extracellular space (Igf2) extracellular region (Igf2)
carbohydrate metabolic process (Igf2)
Anatomy Link Frequency
liver 4
choroid plexus 2
stromal cells 2
masseter 2
placenta 2
Igf2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 29 99.80 Very High Very High Very High
Hippocampus 5 98.36 Very High Very High Very High
anesthesia 4 97.12 Very High Very High Very High
Bile 5 95.00 High High
Neurotransmitter 4 94.72 High High
agonist 15 94.36 High High
Snapping jaw 8 94.00 High High
long-term potentiation 1 91.08 High High
Action potential 14 89.88 High High
diabetic neuropathy 49 88.16 High High
Disease Link Frequency Relevance Heat
Multiple System Atrophy 4 100.00 Very High Very High Very High
Sprains And Strains 22 99.60 Very High Very High Very High
Hypoglycemia 3 99.58 Very High Very High Very High
Malignant Neoplastic Disease 4 99.52 Very High Very High Very High
Diabetes Mellitus 77 99.36 Very High Very High Very High
Phyllodes Tumor 4 99.12 Very High Very High Very High
Aging 67 98.72 Very High Very High Very High
Chronic Hepatitis 2 98.68 Very High Very High Very High
Adenomatous Polyps 1 98.68 Very High Very High Very High
Liver Disease 6 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggested that the patient's hypoglycemia was associated with IGF-II produced by a giant malignant phyllodes tumor that consumed glucose.
Gene_expression (produced) of IGF-II associated with hypoglycemia, phyllodes tumor and malignant neoplastic disease
1) Confidence 0.72 Published 1998 Journal Jpn. J. Clin. Oncol. Section Abstract Doc Link 9657015 Disease Relevance 1.19 Pain Relevance 0.12
The prediction that IGF-I and IGF-II gene expression are reduced in diabetic nerves was recently tested and validated.
Gene_expression (expression) of IGF-II in nerves associated with diabetes mellitus
2) Confidence 0.67 Published 1996 Journal Exp. Neurol. Section Abstract Doc Link 8690062 Disease Relevance 1.12 Pain Relevance 0.24
The objective of this in vitro study was to determine if continuous biophysical strain regulates the gene expression of IGF1, IGF2, IGF1 receptor (IGF1R), insulin receptor substrate (IRS1), and IGF-binding proteins (IGFBP) 3 and 5 in cells from the fibrocartilaginous disc of the temporomandibular joint (TMJ).
Gene_expression (expression) of IGF2 in TMJ associated with snapping jaw and sprains and strains
3) Confidence 0.66 Published 2007 Journal Ann. Anat. Section Abstract Doc Link 17695985 Disease Relevance 0.76 Pain Relevance 0.27
The gene expression of IGF1, IGF2, IGF1R, IRS1, IGFBP3, and IGFBP5 was significantly (p < 0.05) inhibited when cells were subjected to continuous biophysical strain, as compared to control at both time points.
Gene_expression (expression) of IGF2 associated with sprains and strains
4) Confidence 0.66 Published 2007 Journal Ann. Anat. Section Abstract Doc Link 17695985 Disease Relevance 0.99 Pain Relevance 0.27
These results suggest that serum IGF-II reflects a reduced production of IGF-II in the liver and that it can be an index for the residual capacity of liver function.
Gene_expression (production) of IGF-II in liver
5) Confidence 0.66 Published 1989 Journal Dig. Dis. Sci. Section Abstract Doc Link 2537715 Disease Relevance 1.23 Pain Relevance 0.21
Using immunohistochemistry, we confirmed that annulospiral endings of masseter MSA express the glutamate vesicular transporter VGLUT1, indicating that they can release glutamate.
Gene_expression (express) of MSA in masseter
6) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link 20559566 Disease Relevance 0 Pain Relevance 0
The only major difference among groups in carcass and placenta mRNA abundance was a 44% decrease in placental IGF-II expression in UA-lig pups compared with pups from dams that had had no surgery or anesthesia.
Gene_expression (expression) of IGF-II in placenta associated with anesthesia
7) Confidence 0.51 Published 1992 Journal Pediatr. Res. Section Abstract Doc Link 1408464 Disease Relevance 0.28 Pain Relevance 0.18
Decreased IGF-II expression in placenta also may contribute to decreased placental growth and, in turn, to IUGR.
Gene_expression (expression) of IGF-II in placenta associated with intrauterine growth retardation
8) Confidence 0.51 Published 1992 Journal Pediatr. Res. Section Abstract Doc Link 1408464 Disease Relevance 0.15 Pain Relevance 0.14
Igf-2 exhibits high expression at 2 weeks (100- to 500-fold change above average for female and male, respectively) followed by relatively low and constant expression at the remaining age groups.
Gene_expression (expression) of Igf-2
9) Confidence 0.50 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.08 Pain Relevance 0
Serum IGF-II levels (mean +/- SE) were decreased in chronic hepatitis (538 +/- 51 ng/ml; N = 29), liver cirrhosis (427 +/- 45; 50) and PHC (260 +/- 41; 17) compared to controls (830 +/- 49; 57).
Gene_expression (levels) of Serum IGF-II in liver associated with chronic hepatitis, cirrhosis and hepatocellular cancer
10) Confidence 0.50 Published 1989 Journal Dig. Dis. Sci. Section Abstract Doc Link 2537715 Disease Relevance 1.29 Pain Relevance 0.14
For example, the transition from perinatal to pubertal control of growth and differentiation is believed to be directed in part by the switch from, Igf2 (insulin-like growth factor 2) expression to predominantly Igf-1 expression in the liver [36] during early development.
Gene_expression (expression) of insulin-like growth factor 2 in liver
11) Confidence 0.45 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.09 Pain Relevance 0
For example, the transition from perinatal to pubertal control of growth and differentiation is believed to be directed in part by the switch from, Igf2 (insulin-like growth factor 2) expression to predominantly Igf-1 expression in the liver [36] during early development.
Gene_expression (expression) of Igf2 in liver
12) Confidence 0.45 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.09 Pain Relevance 0
expression of IGF-1, IGF-II, IGF-1 receptor and insulin receptor in hippocampus
Gene_expression (expression) of IGF-II in hippocampus associated with hippocampus
13) Confidence 0.21 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2323445 Disease Relevance 1.63 Pain Relevance 0.21
While generally IGF-II could only be detected weakly, in the juvenile cases strong immunostaining for IGF-I in cartilage and bone supposes an influence on pathological growth processes.
Gene_expression (detected) of IGF-II in cartilage
14) Confidence 0.16 Published 2007 Journal Ann. Anat. Section Abstract Doc Link 17695990 Disease Relevance 0.24 Pain Relevance 0.09
Using immunohistochemistry, we confirmed that annulospiral endings of masseter MSA express the glutamate vesicular transporter VGLUT1, indicating that they can release glutamate.
Gene_expression (express) of MSA in masseter associated with glutamate and multiple system atrophy
15) Confidence 0.10 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2886111 Disease Relevance 0.51 Pain Relevance 0.55
In addition, choroid plexus expresses insulin, IGF-I, and IGF-II receptors [11,47]., as well as large amounts of IGF-II that is secreted into the CSF [47].
Gene_expression (expresses) of IGF-II in choroid plexus
16) Confidence 0.10 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC165579 Disease Relevance 0 Pain Relevance 0.09
In addition, choroid plexus expresses insulin, IGF-I, and IGF-II receptors [11,47]., as well as large amounts of IGF-II that is secreted into the CSF [47].
Gene_expression (expresses) of IGF-II in choroid plexus
17) Confidence 0.08 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC165579 Disease Relevance 0 Pain Relevance 0.09
In general, tumor cells were strongly positive for these growth factors in DSRCT, while stromal cells were negative for IGF-II and positive for the other growth factors in parallel with the tumor cells.
Neg (negative) Gene_expression (negative) of IGF-II in stromal cells associated with cancer
18) Confidence 0.05 Published 1998 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 9846206 Disease Relevance 0.89 Pain Relevance 0.06
In general, tumor cells were strongly positive for these growth factors in DSRCT, while stromal cells were negative for IGF-II and positive for the other growth factors in parallel with the tumor cells.
Neg (negative) Gene_expression (negative) of IGF-II in stromal cells associated with cancer
19) Confidence 0.05 Published 1999 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 10074970 Disease Relevance 0.89 Pain Relevance 0.06
Fasting plasma insulin, IGF-I, IGF-II, and IGFBP-3 levels were assessed by ELISA.
Gene_expression (levels) of IGF-II in plasma
20) Confidence 0.04 Published 2005 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 16172212 Disease Relevance 1.32 Pain Relevance 0.05

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