INT93350

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Context Info
Confidence 0.05
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 27.21
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lepr) extracellular space (Lepr) extracellular region (Lepr)
plasma membrane (Lepr)
Anatomy Link Frequency
thyroid 1
posterior 1
optic 1
cytotoxic T lymphocytes 1
Lepr (Mus musculus)
Pain Link Frequency Relevance Heat
Painful diabetic neuropathy 3 98.36 Very High Very High Very High
headache 7 93.08 High High
Pain 58 92.64 High High
Calcium channel 28 92.64 High High
tetrodotoxin 1 92.00 High High
sodium channel 1 91.16 High High
abdominal pain 7 89.60 High High
bradykinin 1 87.84 High High
B1 receptor 2 86.56 High High
tolerance 118 80.96 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 4474 100.00 Very High Very High Very High
Autoimmune Disease 30 99.98 Very High Very High Very High
Diabetic Retinopathy 336 99.92 Very High Very High Very High
Cardiovascular Disease 644 99.86 Very High Very High Very High
Eye Disease 21 99.82 Very High Very High Very High
Glaucoma 266 99.80 Very High Very High Very High
Cataract 154 99.80 Very High Very High Very High
Thyroid Disease 35 99.20 Very High Very High Very High
Vomiting 21 98.94 Very High Very High Very High
Ketosis 35 98.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Even a single conserved residue replacement at position 7 (D-E7) completely abolished the productive interaction between the TCR and the variant NP366/Db ligands, as observed in the case of the Taiwan-NP366/Db ligand (Table S1).
Db Binding (interaction) of
1) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2868023 Disease Relevance 0.43 Pain Relevance 0
45 h after diabetes synchronization with cyclophosphamide, treatment with cSN50 or control was initiated.
diabetes Binding (synchronization) of associated with diabetes mellitus
2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950856 Disease Relevance 0.35 Pain Relevance 0
The MHC class I positive neurons were challenged with CD8+ cytotoxic T lymphocytes (CTL) specific for the H2-Db binding peptide GP33, a dominant epitope of the lymphocytic choriomeningitis virus envelope glycoprotein, or with alloreactive CTL.
H2-Db Binding (binding) of in cytotoxic T lymphocytes associated with lymphocytic choriomeningitis
3) Confidence 0.03 Published 2000 Journal Eur. J. Immunol. Section Abstract Doc Link 11169405 Disease Relevance 0.22 Pain Relevance 0.25
Insulin-dependent type 1 diabetes (T1D) is linked to a series of complications, including painful diabetic neuropathy (PDN).
diabetes Binding (linked) of associated with painful diabetic neuropathy and diabetes mellitus
4) Confidence 0.01 Published 2005 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 16141788 Disease Relevance 1.16 Pain Relevance 0.66
Both cross-sectional and prospective data from three population-based studies, the Beaver Dam Eye Study, the Blue Mountains Eye Study, and the Visual Impairment Project, have documented associations between diabetes and both prevalent and incident posterior subcapsular cataract and, less consistently, with prevalent and incident cortical cataracts but not nuclear cataract (8–12,14–19,23,25).
diabetes Binding (associations) of in posterior associated with diabetes mellitus and cataract
5) Confidence 0.01 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518369 Disease Relevance 1.71 Pain Relevance 0
There are clear biologically plausible mechanisms supporting an association between diabetes and POAG.
diabetes Spec (clear) Binding (association) of associated with diabetes mellitus and glaucoma
6) Confidence 0.01 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518369 Disease Relevance 2.77 Pain Relevance 0
A range of ocular diseases is also associated with diabetes, which may lead to vision loss.
diabetes Binding (associated) of associated with diabetes mellitus and eye disease
7) Confidence 0.01 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518369 Disease Relevance 1.17 Pain Relevance 0
Numerous studies have documented an association between diabetes and cataracts.
diabetes Binding (association) of associated with diabetes mellitus and cataract
8) Confidence 0.01 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518369 Disease Relevance 1.71 Pain Relevance 0
Several large epidemiological studies have reported positive associations between diabetes with primary open angle glaucoma (POAG), the most common form of primary glaucoma, or elevated intraocular pressure in the absence of glaucoma optic neuropathy (59–63).
diabetes Binding (associations) of in optic associated with diabetes mellitus, glaucoma, ocular hypertension and optic disorders
9) Confidence 0.01 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518369 Disease Relevance 3.02 Pain Relevance 0
A wide spectrum of ocular conditions other than diabetic retinopathy is associated with diabetes.
diabetes Binding (associated) of associated with diabetes mellitus and diabetic retinopathy
10) Confidence 0.01 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518369 Disease Relevance 2.88 Pain Relevance 0.04
Studies have shown a consistent association between diabetes and neovascular glaucoma (81), with proliferative retinopathy the leading cause of this type of secondary glaucoma.
diabetes Binding (association) of associated with diabetes mellitus, glaucoma and diabetic retinopathy
11) Confidence 0.01 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518369 Disease Relevance 2.74 Pain Relevance 0.23
Marked hyperglycemia requires temporary adjustment of the treatment program and, if accompanied by ketosis, vomiting, or alteration in level of consciousness, immediate interaction with the diabetes care team.
diabetes Binding (interaction) of associated with hyperglycemia, diabetes mellitus, ketosis and vomiting
12) Confidence 0.00 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797382 Disease Relevance 1.66 Pain Relevance 0
In 1997 and 2003, The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (4,7) recognized an intermediate group of individuals whose glucose levels, although not meeting criteria for diabetes, are nevertheless too high to be considered normal.
Diabetes Binding (recognized) of associated with diabetes mellitus
13) Confidence 0.00 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797382 Disease Relevance 0.97 Pain Relevance 0.14
Autoimmune thyroid disease is the most common autoimmune disorder associated with diabetes, occurring in 17–30% of patients with type 1 diabetes (330).
diabetes Binding (associated) of in thyroid associated with autoimmune disease, diabetes mellitus and thyroid disease
14) Confidence 0.00 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797382 Disease Relevance 2.33 Pain Relevance 0.09
Any plan should recognize diabetes self-management education (DSME) and on-going diabetes support as an integral component of care.
diabetes Binding (recognize) of associated with diabetes mellitus
15) Confidence 0.00 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797382 Disease Relevance 0.71 Pain Relevance 0
Post hoc subgroup analyses suggested that duration of diabetes interacted with randomization such that participants with duration of diabetes less than about 12 years appeared to have a CVD benefit of intensive glycemic control while those with longer duration of disease prior to study entry had a neutral or even adverse effect of intensive glycemic control.
diabetes Binding (interacted) of associated with cardiovascular disease, diabetes mellitus and disease
16) Confidence 0.00 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797382 Disease Relevance 0.97 Pain Relevance 0
Ideally, people with diabetes should be taught at a time and place conducive to learning—as an outpatient in a recognized program of diabetes education.
diabetes Binding (recognized) of associated with diabetes mellitus
17) Confidence 0.00 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797382 Disease Relevance 0.67 Pain Relevance 0
Though evidence for distinct advantages of RAS inhibitors on CVD outcomes in diabetes remains conflicting (187,207), the high CVD risks associated with diabetes, and the high prevalence of undiagnosed CVD, may still favor recommendations for their use as first-line hypertension therapy in people with diabetes (184).
diabetes Binding (associated) of associated with diabetes mellitus, cardiovascular disease and hypertension
18) Confidence 0.00 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797382 Disease Relevance 1.73 Pain Relevance 0.10

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