INT93355

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.92
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Trp53) mitochondrion (Trp53) endoplasmic reticulum (Trp53)
enzyme binding (Trp53) protein complex assembly (Trp53) DNA binding (Trp53)
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 11 95.80 Very High Very High Very High
Hippocampus 1 90.28 High High
Enkephalin 2 75.00 Quite High
Opioid 2 75.00 Quite High
Dopamine 1 56.40 Quite High
tolerance 7 51.36 Quite High
Inflammation 12 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 130 94.88 High High
Pox Virus Infection 11 82.20 Quite High
Drug Induced Neurotoxicity 4 65.68 Quite High
Non-small-cell Lung Cancer 3 63.68 Quite High
Disease 7 56.40 Quite High
Immunotherapy Of Cancer 10 44.72 Quite Low
Skin Cancer 5 25.76 Quite Low
Malignant Neoplastic Disease 2 16.12 Low Low
INFLAMMATION 13 5.00 Very Low Very Low Very Low
Papillomavirus Infection 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DADLE blocked both the increase of p53 mRNA and the decrease of p53 protein caused by METH.
Negative_regulation (blocked) of Negative_regulation (decrease) of p53
1) Confidence 0.41 Published 2001 Journal Synapse Section Abstract Doc Link 11169780 Disease Relevance 0.18 Pain Relevance 0.22
Replacing defective genes (p53, BRCA1, RB, p16) [35, 38]
Negative_regulation (Replacing) of Negative_regulation (defective) of p53
2) Confidence 0.06 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 0.74 Pain Relevance 0.07

General Comments

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