INT93357

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Context Info
Confidence 0.62
First Reported 2001
Last Reported 2011
Negated 5
Speculated 2
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 13.40
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Trp53) mitochondrion (Trp53) endoplasmic reticulum (Trp53)
enzyme binding (Trp53) protein complex assembly (Trp53) DNA binding (Trp53)
Anatomy Link Frequency
neuronal 2
poly 2
lung 2
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 15 98.30 Very High Very High Very High
Hippocampus 24 83.00 Quite High
Nerve growth factor 1 79.68 Quite High
Inflammation 28 79.44 Quite High
Bile 12 76.12 Quite High
antagonist 4 75.00 Quite High
Opioid 2 75.00 Quite High
Enkephalin 2 75.00 Quite High
Analgesic 2 74.80 Quite High
medulla 17 74.76 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 276 100.00 Very High Very High Very High
Targeted Disruption 153 99.96 Very High Very High Very High
Glioma 92 99.84 Very High Very High Very High
Stress 37 99.38 Very High Very High Very High
Myeloid Leukemia 8 99.36 Very High Very High Very High
Hepatotoxicity 9 98.76 Very High Very High Very High
Malignant Neoplastic Disease 38 98.40 Very High Very High Very High
Lung Cancer 6 97.88 Very High Very High Very High
Aging 44 97.16 Very High Very High Very High
Klatskin's Tumor 28 96.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Numerous studies have also been carried out in order to investigate the effects of p53 overexpression in glioma cells.
Spec (investigate) Regulation (effects) of Spec (investigate) Gene_expression (overexpression) of p53 associated with glioma
1) Confidence 0.62 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.09 Pain Relevance 0
One guess is that the Trp53-null status directly or indirectly allows for proliferation of Pdgfr?
Regulation (allows) of Gene_expression (status) of Trp53-null
2) Confidence 0.45 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.48 Pain Relevance 0
The mechanism appears to involve blunting p53 mediated apoptosis by down-regulating p53 expression.
Regulation (regulating) of Gene_expression (expression) of p53 associated with apoptosis
3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 0.54 Pain Relevance 0
In our study, there was no difference in p53 and cyclin D1 overexpression based on anatomic site, and also they were no prognostic impact on survival in BDC and GB cancer, respectively.
Neg (no) Regulation (difference) of Gene_expression (overexpression) of p53 associated with klatskin's tumor and cancer
4) Confidence 0.35 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 1.48 Pain Relevance 0.04
First, we examined if MYC activation affected p53 protein expression.
Spec (examined) Regulation (affected) of Gene_expression (expression) of p53
5) Confidence 0.34 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.68 Pain Relevance 0
The association between cox-2 and p53 expression
Regulation (association) of Gene_expression (expression) of p53
6) Confidence 0.31 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2853498 Disease Relevance 0.16 Pain Relevance 0
These results demonstrate a neuroprotective effect of DADLE against the neuronal damage and the alteration of p53 gene expression caused by a single high dose of METH.
Regulation (alteration) of Gene_expression (expression) of p53 in neuronal
7) Confidence 0.26 Published 2001 Journal Synapse Section Abstract Doc Link 11169780 Disease Relevance 0.11 Pain Relevance 0.19
This study investigated the effect of AAP on the expression of these oncogenes and whether agents that modulate DNA fragmentation (chlorpromazine, CPZ) and DNA repair through poly(ADP-Ribose) polymerase (PARP) activity (4-AB: 4-aminobenzamide) can protect against AAP-induced hepatotoxicity by inhibiting oxidative stress, DNA fragmentation, and/or by altering the expression of bcl-XL and p53.
Regulation (altering) of Gene_expression (expression) of p53 in poly associated with stress, paracetamol and hepatotoxicity
8) Confidence 0.25 Published 2001 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11461765 Disease Relevance 0.67 Pain Relevance 0.73
It has also been proposed, that otherwise benign appearing lesions showing an over-expression of p53 in some of the cells implies the expression of mutated p53 which may be an indicator of potential malignant development.
Regulation (implies) of Gene_expression (expression) of p53 associated with malignant neoplastic disease
9) Confidence 0.23 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1386691 Disease Relevance 1.22 Pain Relevance 0
This model, and another one that involves expression of k-ras mutant and p53 knockout, requires extensive animal breeding and genotyping, which greatly limits its use for the purpose of studying new therapeutic or preventive methods or agents.
Regulation (involves) of Gene_expression (expression) of p53 associated with targeted disruption
10) Confidence 0.18 Published 2006 Journal J Carcinog Section Body Doc Link PMC1559682 Disease Relevance 0.81 Pain Relevance 0
However, Sami et al. reported the efficacy of VPA with no effect on p53 expression [18].
Neg (no) Regulation (effect) of Gene_expression (expression) of p53
11) Confidence 0.11 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.73 Pain Relevance 0.03
However, Chang et al. found that gossypol did not affect cell cycle progression or the p53 or p21/WAF signaling pathway in A549 human alveolar lung cancer cells [10].
Neg (not) Regulation (affect) of Gene_expression (progression) of p53 in lung associated with lung cancer
12) Confidence 0.09 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 1.24 Pain Relevance 0
We observed no changes in p53 protein expression (Fig. 3B).
Neg (no) Regulation (changes) of Gene_expression (expression) of p53
13) Confidence 0.09 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 0.32 Pain Relevance 0
Over-expression of MIF down regulated p53 levels and suppressed nuclear localization, thereby prohibiting its transcriptional activity.
Regulation (regulated) of Gene_expression (expression) of p53
14) Confidence 0.09 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.33 Pain Relevance 0.19
No significant change in p53 expressions was observed in either cell line transfected with PTTG1.
Neg (No) Regulation (change) of Gene_expression (expressions) of p53
15) Confidence 0.08 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.84 Pain Relevance 0
However, there is no significant difference in the expression of pro-apoptotic protein p53 content values between SAMP10 and SAMR1 [22] as observed in SAMP8 (unpublished results).
Regulation (values) of Gene_expression (expression) of p53 associated with apoptosis
16) Confidence 0.03 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1766358 Disease Relevance 0.97 Pain Relevance 0.17
VPA appears to induce an increase in the amount of p21WAF1 protein over 48 hours in AML cells, which is independent of p53 levels (whose expression is not modulated by VPA), but appears to be dependent on c-myc, whose mRNA and protein levels decrease in a dose-dependent manner during VPA treatment.
Regulation (modulated) of Gene_expression (expression) of p53 associated with myeloid leukemia
17) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.70 Pain Relevance 0.07

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