INT93358

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.95
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Trp53) mitochondrion (Trp53) endoplasmic reticulum (Trp53)
enzyme binding (Trp53) protein complex assembly (Trp53) DNA binding (Trp53)
Anatomy Link Frequency
neuronal 2
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 9 99.12 Very High Very High Very High
Opioid 4 75.00 Quite High
Enkephalin 4 75.00 Quite High
Eae 6 71.12 Quite High
Dopamine 2 65.24 Quite High
cINOD 5 24.16 Low Low
cytokine 18 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
long-term potentiation 5 5.00 Very Low Very Low Very Low
Kinase C 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 148 99.44 Very High Very High Very High
Stress 35 99.32 Very High Very High Very High
Skin Cancer 24 98.92 Very High Very High Very High
Toxicity 15 98.90 Very High Very High Very High
Targeted Disruption 4 97.56 Very High Very High Very High
Cancer 142 96.80 Very High Very High Very High
Disease 131 96.52 Very High Very High Very High
Death 56 96.44 Very High Very High Very High
Aging 7 84.52 Quite High
Rhinitis 2 78.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DADLE blocked both the increase of p53 mRNA and the decrease of p53 protein caused by METH.
Negative_regulation (blocked) of Positive_regulation (increase) of p53 mRNA
1) Confidence 0.41 Published 2001 Journal Synapse Section Abstract Doc Link 11169780 Disease Relevance 0.18 Pain Relevance 0.22
DADLE abolished the p53 mRNA increase caused by METH.
Negative_regulation (abolished) of Positive_regulation (increase) of p53 mRNA
2) Confidence 0.40 Published 2001 Journal Synapse Section Abstract Doc Link 11169780 Disease Relevance 0.27 Pain Relevance 0.34
Studying cells at different phases of transformation, we could show that an early event during transformation was the loss of expression of the CDKN2A locus, followed by inactivation of p53 and overexpression of c-myc.
Negative_regulation (loss) of Positive_regulation (inactivation) of p53
3) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.59 Pain Relevance 0
Treatment with tacrolimus leads to Erk activation in neuronal cells and inhibits the induction of p53 following an apoptotic stimulus in several cell systems [19-22].
Negative_regulation (inhibits) of Positive_regulation (induction) of p53 in neuronal associated with apoptosis
4) Confidence 0.22 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1386691 Disease Relevance 0.60 Pain Relevance 0
TM2H cells (p53 null), in contrast, lack both negative regulatory potentials of acetylated p53 and the availability of nuclear p21.
Negative_regulation (lack) of Positive_regulation (acetylated) of p53
5) Confidence 0.21 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0.15 Pain Relevance 0
It was initially speculated that the high efficiency of iPS cell generation from GFs might have been due to high endogenous expression levels of at least one of the four defined pluripotency-inducing factors, or due to reduced activation of the p53 pathway [39], [40].
Negative_regulation (reduced) of Positive_regulation (activation) of p53
6) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939066 Disease Relevance 0.13 Pain Relevance 0
Also, results from our group have shown that p53 accumulation and p53-dependent gene activation are compromised in parp-1 knockout cells after ?
Negative_regulation (shown) of Positive_regulation (accumulation) of p53 associated with targeted disruption
7) Confidence 0.10 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.17 Pain Relevance 0
USC-HN1 cells demonstrate strong, uniform nuclear p53 and Rb expression, as well as positive expression of keratin, E-cadherin, EGFr, and CD44 in situ consistent with HNSCC as well as the original tumor biopsy [4,7,13,19].
Negative_regulation (demonstrate) of Positive_regulation (nuclear) of p53 associated with cancer
8) Confidence 0.08 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 1.13 Pain Relevance 0
- toxicity and oxidative stress [152] by a mechanism mediated by reduced PI3K/Akt signaling and JNK/p53 activation, thus providing a link between NGF deprivation and the two pathological components of AD.
Negative_regulation (reduced) of Positive_regulation (activation) of p53 associated with stress, toxicity and disease
9) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.72 Pain Relevance 0.04

General Comments

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