INT9336

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Context Info
Confidence 0.42
First Reported 1992
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.53
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Igf1r)
Anatomy Link Frequency
sciatic nerve 2
hippocampus 2
uterine artery 2
Igf1r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 4 100.00 Very High Very High Very High
Hippocampus 3 100.00 Very High Very High Very High
Sciatic nerve 2 100.00 Very High Very High Very High
fluoxetine 10 99.68 Very High Very High Very High
unmyelinated 2 90.88 High High
Snapping jaw 3 90.04 High High
Hyperalgesia 1 88.48 High High
antidepressant 2 79.56 Quite High
dorsal root ganglion 1 68.04 Quite High
anesthesia 2 66.16 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 7 100.00 Very High Very High Very High
Intrauterine Growth Retardation 4 99.76 Very High Very High Very High
Diabetes Mellitus 9 99.52 Very High Very High Very High
Sprains And Strains 8 97.88 Very High Very High Very High
Temporomandibular Joint Syndrome 3 90.04 High High
Cognitive Disorder 3 88.56 High High
Hyperalgesia 1 88.48 High High
Body Weight 1 84.08 Quite High
Nociception 5 75.00 Quite High
Neuropathic Pain 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insulin receptor and IGF-I receptor (IGF-IR) expressions in DRGs and NGF content in sciatic nerve were significantly decreased in 7-month diabetic rats (P < 0.01, 0.05, and 0.005, respectively).
Negative_regulation (decreased) of Gene_expression (expressions) of IGF-I receptor in sciatic nerve associated with nerve growth factor, diabetes mellitus and sciatic nerve
1) Confidence 0.42 Published 2006 Journal Diabetes Section Abstract Doc Link 17130507 Disease Relevance 1.41 Pain Relevance 0.48
The gene expression of IGF1, IGF2, IGF1R, IRS1, IGFBP3, and IGFBP5 was significantly (p < 0.05) inhibited when cells were subjected to continuous biophysical strain, as compared to control at both time points.
Negative_regulation (inhibited) of Gene_expression (expression) of IGF1R associated with sprains and strains
2) Confidence 0.41 Published 2007 Journal Ann. Anat. Section Abstract Doc Link 17695985 Disease Relevance 1.01 Pain Relevance 0.27
Acute FLX administration decreased IGF-1 mRNA levels in the FC and hippocampus and increased IGF-1R levels in the FC.
Negative_regulation (decreased) of Gene_expression (levels) of IGF-1R in hippocampus associated with urological neuroanatomy, hippocampus and fluoxetine
3) Confidence 0.39 Published 2008 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17961991 Disease Relevance 0.73 Pain Relevance 1.11
We assessed the expression of IGF, IGF binding protein (IGFBP), and IGF receptor transcripts in liver, carcass, and placenta of fetal rats with IUGR resulting from unilateral uterine artery ligation.
Negative_regulation (assessed) of Gene_expression (expression) of IGF receptor in uterine artery associated with intrauterine growth retardation
4) Confidence 0.07 Published 1992 Journal Pediatr. Res. Section Abstract Doc Link 1408464 Disease Relevance 0.38 Pain Relevance 0.07

General Comments

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