INT93360

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2010
Negated 7
Speculated 3
Reported most in Body
Documents 63
Total Number 70
Disease Relevance 19.54
Pain Relevance 26.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc6a3) plasma membrane (Slc6a3) transmembrane transport (Slc6a3)
Anatomy Link Frequency
striatum 13
neurons 5
midbrain 3
internal 1
reservoir 1
Slc6a3 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 3696 100.00 Very High Very High Very High
cocaine 2780 100.00 Very High Very High Very High
opioid receptor 9 99.88 Very High Very High Very High
MU agonist 1 99.64 Very High Very High Very High
midbrain 387 99.44 Very High Very High Very High
monoamine 218 99.20 Very High Very High Very High
Eae 625 98.28 Very High Very High Very High
Serotonin 98 97.36 Very High Very High Very High
addiction 36 97.04 Very High Very High Very High
Nucleus accumbens 119 96.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 312 99.96 Very High Very High Very High
Urological Neuroanatomy 27 99.84 Very High Very High Very High
Disease 1310 99.62 Very High Very High Very High
Parkinson's Disease 1273 99.34 Very High Very High Very High
Aging 201 98.84 Very High Very High Very High
Apoptosis 130 98.12 Very High Very High Very High
Drug Induced Neurotoxicity 91 97.76 Very High Very High Very High
Opiate Addiction 4 97.32 Very High Very High Very High
Sprains And Strains 116 97.08 Very High Very High Very High
Syndrome 6 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies indicate that alterations in DAT expression can change an animal's behavior and modify its response to drugs including psychostimulants.
Gene_expression (expression) of DAT
1) Confidence 0.78 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0.29 Pain Relevance 0.52
Although the elevated basal DA tone is due to reduced DAT activity in all mouse lines, the causes of the reduction are different; reduced expression of wild type DAT, in heterozygous DAT-KO and DAT-KD mice, versus normal expression of a mutant DAT with lower uptake activity in DAT-CI mice.
Gene_expression (expression) of DAT associated with dopamine
2) Confidence 0.78 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.51
The fact that cocaine retains these effects in both heterozygous DAT-KO mice and DAT-KD mice indicates that the reduction of DAT expression and thus DAT activity to 50% and 10% of wild type mice does not by itself lead to adaptive changes that abolish the stimulating effect of cocaine and in fact, 10% DAT activity seems to be sufficient for the preservation of many normal functions, such as some cocaine responses.
Gene_expression (expression) of DAT associated with cocaine
3) Confidence 0.78 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.66
In a previous report we first detected DAT-Cre mediated beta galactosidase expression in a conditional Rosa26LacZ reporter mice at embryonic day 17 [15], suggesting excision of Pten exon5 at around this developmental point.
Gene_expression (expression) of DAT-Cre
4) Confidence 0.70 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.33 Pain Relevance 0.39
DAT is a molecular substrate specific to dopamine neurons and is highly expressed in dopamine neurons of the ventral midbrain, while lesser expression levels are present in the olfactory bulb and hypothalamic areas.
Gene_expression (expressed) of DAT in midbrain associated with dopamine and midbrain
5) Confidence 0.70 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.15 Pain Relevance 0.29
To establish a mouse model carrying Pten deletion in cells expressing DAT, we crossed Pten loxP mice with a Slc6a3Cre transgenic line.
Gene_expression (expressing) of DAT associated with targeted disruption
6) Confidence 0.70 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.10 Pain Relevance 0.08
A DAT knock-down mouse line (DAT-KD) has been generated which has a 90% reduction in DAT expression compared to the wild type mice [18].
Gene_expression (expression) of DAT associated with targeted disruption
7) Confidence 0.68 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0.35 Pain Relevance 0.61
Although the elevated basal DA tone is due to reduced DAT activity in all mouse lines, the causes of the reduction are different; reduced expression of wild type DAT, in heterozygous DAT-KO and DAT-KD mice, versus normal expression of a mutant DAT with lower uptake activity in DAT-CI mice.
Gene_expression (expression) of DAT associated with dopamine
8) Confidence 0.68 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.49
Thus, we examined whether cocaine is still able to produce reward in DAT-KD mice that have only 10% of wild type DAT expression.
Gene_expression (expression) of DAT associated with cocaine
9) Confidence 0.68 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.55
Although the elevated basal DA tone is due to reduced DAT activity in all mouse lines, the causes of the reduction are different; reduced expression of wild type DAT, in heterozygous DAT-KO and DAT-KD mice, versus normal expression of a mutant DAT with lower uptake activity in DAT-CI mice.
Gene_expression (expression) of DAT-KO associated with dopamine
10) Confidence 0.67 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.52
It is likely that the absence of DAT in DAT-KO mice has altered neuronal signaling pathways.
Neg (absence) Gene_expression (absence) of DAT in neuronal
11) Confidence 0.67 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0.35 Pain Relevance 0.74
However, DAT activity in DAT-CI mice is significantly lower than that in wild type mice, and changes in DAT have been shown to alter behaviors or drug responses.
Gene_expression (activity) of DAT
12) Confidence 0.67 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0.09 Pain Relevance 0.64
However, DAT activity in DAT-CI mice is significantly lower than that in WT mice.
Gene_expression (activity) of DAT
13) Confidence 0.67 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.52
Several mouse models have been generated with alterations to the DAT gene, providing excellent tools to study the functions of DAT and the mechanism of cocaine effects: DAT-KD mice [18] and heterozygous DAT-KO mice [24] with DAT expression reduced to 10% and 50% of the wild type level respectively, DAT-CI mice [17] with a cocaine-insensitive DAT mutant that is functional but with reduced uptake activity, and homozygous DAT-KO mice [24] with DAT completely deleted.
Gene_expression (expression) of DAT-KO associated with cocaine
14) Confidence 0.67 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.59
These results suggest that genetic differences in MOP-r activation and DAT expression may be responsible for individual differences in vulnerability to heroin addiction.
Gene_expression (expression) of DAT associated with addiction and opiate addiction
15) Confidence 0.65 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20384817 Disease Relevance 0.44 Pain Relevance 0.32
Importantly, in the frontal cortex, where DAT levels are normally low in comparison to the striatum, tissue DA concentration is also low and can be more significantly affected than in the striatum by ?
Gene_expression (levels) of DAT in striatum associated with dopamine and urological neuroanatomy
16) Confidence 0.62 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.10 Pain Relevance 0.79
However, several lines of evidence support a predominant role of DAT-mediated recycling of DA for the maintenance of the large storage pool in DA terminals.
Gene_expression (recycling) of DAT-mediated associated with dopamine
17) Confidence 0.62 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.12 Pain Relevance 0.74
To confirm if Pten deletion was specific to DAT expressing regions, primers specific to the recombination (delta5) were developed.
Gene_expression (expressing) of DAT
18) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.15 Pain Relevance 0.25
In DAT-Cre conditional transgenic mice, Cre recombinase activity is induced shortly after DAT induction.
Gene_expression (induction) of DAT associated with targeted disruption
19) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.33 Pain Relevance 0.39
UTR) of the DAT gene where the Cre gene is preceded by an internal ribosomal entry site (IRES).
Gene_expression (preceded) of DAT in internal
20) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.24 Pain Relevance 0.46

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