INT93361

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2011
Negated 11
Speculated 6
Reported most in Body
Documents 208
Total Number 214
Disease Relevance 175.35
Pain Relevance 16.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Trp53) mitochondrion (Trp53) endoplasmic reticulum (Trp53)
enzyme binding (Trp53) protein complex assembly (Trp53) DNA binding (Trp53)
Anatomy Link Frequency
fibroblasts 6
brain 5
epithelial cell 3
MCF-7 2
nucleus 2
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 78 99.84 Very High Very High Very High
Somatostatin 211 99.82 Very High Very High Very High
metalloproteinase 107 99.82 Very High Very High Very High
cytokine 424 99.78 Very High Very High Very High
Spinal cord 6 99.68 Very High Very High Very High
methotrexate 23 99.50 Very High Very High Very High
COX2 4 99.20 Very High Very High Very High
rheumatoid arthritis 331 98.72 Very High Very High Very High
palliative 66 98.72 Very High Very High Very High
narcan 10 98.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 7714 100.00 Very High Very High Very High
Apoptosis 3267 100.00 Very High Very High Very High
Renal Cancer 66 100.00 Very High Very High Very High
Repression 59 100.00 Very High Very High Very High
Viral Infection 39 100.00 Very High Very High Very High
Targeted Disruption 1131 99.96 Very High Very High Very High
Breast Cancer 366 99.86 Very High Very High Very High
Glioma 956 99.84 Very High Very High Very High
Lung Cancer 86 99.84 Very High Very High Very High
Carcinoma 587 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apoptosis is however not frequently seen upon retroviral expression or activation of endogenous p53 in glioma cell lines [36], but overexpression of p53 by adenovirus may sensitize glioma cells to apoptosis [155].
Gene_expression (overexpression) of p53 associated with apoptosis and glioma
1) Confidence 0.78 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.71 Pain Relevance 0
Whereas glioma cell lines expressing mutant p53 are sensitized to temozolomide, the status of p53 does not seem to affect the response of brain tumor stem cells treated with this drug [141].
Gene_expression (expressing) of p53 in brain associated with brain tumor and glioma
2) Confidence 0.78 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.25 Pain Relevance 0.10
Numerous studies have also been carried out in order to investigate the effects of p53 overexpression in glioma cells.
Spec (investigate) Gene_expression (overexpression) of p53 associated with glioma
3) Confidence 0.78 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.09 Pain Relevance 0
Later, it was found that p53 is expressed at higher levels in cells in the neural stem cell niche than in other regions of the adult mouse brain [73].
Gene_expression (expressed) of p53 in neural
4) Confidence 0.78 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.95 Pain Relevance 0.05
We must also take into consideration that activation of p53 may lead to the emergence of treatment resistant brain tumor cells that express mutant p53 or that have completely lost p53.
Gene_expression (express) of p53 in brain associated with brain tumor
5) Confidence 0.78 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.56 Pain Relevance 0.06
Both astrocytes and oligodendrocytes can undergo apoptosis following infection with an adenovirus expressing p53 [88].
Gene_expression (expressing) of p53 in oligodendrocytes associated with apoptosis and infection
6) Confidence 0.78 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.94 Pain Relevance 0.07
They found that a majority of mice developed malignant brain tumors and that the same mutant p53 was detected in the tumor cells but not in normal cells.
Neg (not) Gene_expression (detected) of p53 in brain associated with malignant neoplastic disease, cancer and brain tumor
7) Confidence 0.78 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.09 Pain Relevance 0.04
Oligodendrocyte precursors cultured in vitro can undergo p53-dependent differentiation although the cells appear to have a low basal level of p53 expression [87].
Gene_expression (expression) of p53 in Oligodendrocyte
8) Confidence 0.78 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.88 Pain Relevance 0.08
Indeed, adenoviral expression of p53 has been extensively tested in glioma [156].
Gene_expression (expression) of p53 associated with glioma
9) Confidence 0.78 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.63 Pain Relevance 0
Moreover, p53 expression in the spinal cord had increased significantly 14h after the last morphine administration.
Gene_expression (expression) of p53 in spinal cord associated with morphine and spinal cord
10) Confidence 0.78 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19084050 Disease Relevance 0.14 Pain Relevance 1.11
These results indicate that the increased expression and activation of p53, and the nitric oxide and caspase systems related to p53 may contribute to the development of antinociceptive tolerance to morphine in the mouse spinal cord.
Gene_expression (expression) of p53 in spinal cord associated with tolerance, antinociceptive, spinal cord and morphine
11) Confidence 0.78 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19084050 Disease Relevance 0.13 Pain Relevance 1.11
INTRODUCTION: Thymidylate synthase (TS) and p53 expression have been reported to predict the results of palliative chemotherapy in advanced colorectal carcinoma (ACRC), but the knowledge is still limited and partly conflicting.
Gene_expression (expression) of p53 associated with colon cancer and palliative
12) Confidence 0.75 Published 2002 Journal Anticancer Res. Section Abstract Doc Link 12552972 Disease Relevance 0.25 Pain Relevance 0.10
Thymidylate synthase and p53 expression in primary tumor do not predict chemotherapy outcome in metastatic colorectal carcinoma.
Gene_expression (expression) of p53 associated with cancer, colon cancer and methotrexate
13) Confidence 0.75 Published 2002 Journal Anticancer Res. Section Title Doc Link 12552972 Disease Relevance 0.20 Pain Relevance 0.14
These results demonstrate a neuroprotective effect of DADLE against the neuronal damage and the alteration of p53 gene expression caused by a single high dose of METH.
Gene_expression (expression) of p53 in neuronal
14) Confidence 0.73 Published 2001 Journal Synapse Section Abstract Doc Link 11169780 Disease Relevance 0.11 Pain Relevance 0.19
In addition, since the tumor suppressor p53 has been implicated in the neurotoxicity of METH, this study also examined the levels of p53 mRNA and protein affected by METH and DADLE.
Spec (examined) Gene_expression (levels) of p53 mRNA associated with drug induced neurotoxicity and cancer
15) Confidence 0.73 Published 2001 Journal Synapse Section Abstract Doc Link 11169780 Disease Relevance 0.36 Pain Relevance 0.38
We assessed the expression of p53 and Her2 in both original tumor tissues and cell lines.
Gene_expression (expression) of p53 associated with cancer
16) Confidence 0.71 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2467432 Disease Relevance 0.81 Pain Relevance 0
We also examined p53 expression by immunohistochemistry.
Spec (examined) Gene_expression (expression) of p53
17) Confidence 0.71 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2467432 Disease Relevance 0.75 Pain Relevance 0
Solid tumor and cell line expression of keratins, TP53 and HER2
Gene_expression (expression) of TP53 associated with solid tumor
18) Confidence 0.71 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2467432 Disease Relevance 0.86 Pain Relevance 0
The effect of AAP on bcl-XL was antagonized and that on p53 was synergized by the PARP-modulator 4-AB as well as NICO, whereas the endonuclease inhibitor CPZ was without effect on either bcl-XL or p53 expression.
Gene_expression (expression) of p53 associated with paracetamol
19) Confidence 0.71 Published 2001 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11461765 Disease Relevance 0.51 Pain Relevance 0.82
Ca(2+)-calmodulin antagonist chlorpromazine and poly(ADP-ribose) polymerase modulators 4-aminobenzamide and nicotinamide influence hepatic expression of BCL-XL and P53 and protect against acetaminophen-induced programmed and unprogrammed cell death in mice.
Gene_expression (expression) of P53 in poly associated with paracetamol, antagonist and death
20) Confidence 0.71 Published 2001 Journal Free Radic. Biol. Med. Section Title Doc Link 11461765 Disease Relevance 0.69 Pain Relevance 0.70

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